CH209827A - Process for the preparation of a thiazolium compound. - Google Patents

Process for the preparation of a thiazolium compound.

Info

Publication number
CH209827A
CH209827A CH209827DA CH209827A CH 209827 A CH209827 A CH 209827A CH 209827D A CH209827D A CH 209827DA CH 209827 A CH209827 A CH 209827A
Authority
CH
Switzerland
Prior art keywords
methyl
preparation
thiazolium
compound
hydroiodide
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH209827A publication Critical patent/CH209827A/en

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  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Darstellung einer     Thiazoliumverbindung.       Das Hauptpatent betrifft die Herstellung  einer durch     antineuritische    Wirkung ausge  zeichneten     Pyrimidylalkyltbiazoliumverbin-          dung.     



  Gegenstand des vorliegenden Patentes ist  ein Verfahren zur Herstellung einer     Thiazo-          liumverbindung,    dadurch gekennzeichnet, dass  man     2-blethyl-4-amino-5-jodmethyl-pyrimidin-          hydrojodid    auf     4-Methyl-5-acetogyäthyl-thiazol     einwirken lässt. Das so erhältliche     Hydrojodid     des N-(2'-Methyl-4'-amino-pyrimidyl-[5']       methyl)-4-methyl-5-acetoxyäthyl-thiazolium-          jodids    bildet Kristalle vom F.<B>215'.</B> Die  Verbindung zeigt eine starke     antineuritische     Wirksamkeit und soll therapeutische Anwen  dung finden.  



       Beispiel:     5 g     2-Methyl-4-amino-5-jodmethyl-pyrimi-          din-hydrojodid    werden mit 5 g     4-Methyl-5-          acetoxyäthyl--thiazol        1/2    Stunde auf 120 bis  <B>1300</B> erhitzt. Die Schmelze wird mit Äther    verrührt und das zurückbleibende Pulver aus  Alkohol und etwas Wasser umkristallisiert.  Man erhält das     Hydrojodid    des     N-(2'-Methyl-          4'-amino-pyrimidyl-        [5']        -methyl)-4-methyl-5-          acetoxyäthyl-thiazoliumjodids    in Kristallen  vom F. 2150.

   Die Verbindung zeigt eine  starke     antineuritische    Wirksamkeit.



  Process for the preparation of a thiazolium compound. The main patent relates to the production of a pyrimidylalkyltbiazolium compound which is distinguished by its antineuritic effect.



  The present patent relates to a process for the preparation of a thiazole compound, characterized in that 2-methyl-4-amino-5-iodomethyl-pyrimidine-hydroiodide is allowed to act on 4-methyl-5-acetogyethyl-thiazole. The hydroiodide of N- (2'-methyl-4'-aminopyrimidyl- [5 '] methyl) -4-methyl-5-acetoxyethyl-thiazolium iodide which can be obtained in this way forms crystals of F. <B> 215'. < / B> The compound shows strong anti-neuritic activity and is said to find therapeutic use.



       Example: 5 g of 2-methyl-4-amino-5-iodomethyl-pyrimidine hydroiodide are mixed with 5 g of 4-methyl-5-acetoxyethyl thiazole for 1/2 hour to 120 to 1300 heated. The melt is stirred with ether and the remaining powder is recrystallized from alcohol and a little water. The hydroiodide of N- (2'-methyl-4'-aminopyrimidyl- [5 '] -methyl) -4-methyl-5-acetoxyethyl-thiazolium iodide is obtained in crystals with a melting point of 2150.

   The compound shows strong anti-neuritic activity.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung einer Thiazo- liumverbindung, dadurch gekennzeichnet, dass man 2-Methyl-4-amino-5-jodmethyl-pyrimidin- hydrojodid auf 4-Methyl-5-acetoxyäthyl-thi- azol einwirken lässt. PATENT CLAIM: Process for the production of a thiazolium compound, characterized in that 2-methyl-4-amino-5-iodomethyl-pyrimidine-hydroiodide is allowed to act on 4-methyl-5-acetoxyethyl-thiazole. Das so erhältliche Hydrojodid des'N-(2'- Methyl - 4'- amino - pyrimidyl - [5'] - methyl) - 4- methyl-5-acetoxyäthyl-thiazoliumjodids bildet Kristalle vom F. 2150. The thus obtainable hydroiodide des'N- (2'-methyl-4'-amino-pyrimidyl- [5 '] -methyl) -4-methyl-5-acetoxyethyl-thiazolium iodide forms crystals of F. 2150.
CH209827D 1936-01-28 1937-01-08 Process for the preparation of a thiazolium compound. CH209827A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE209827X 1936-01-28
CH202663T 1937-01-08

Publications (1)

Publication Number Publication Date
CH209827A true CH209827A (en) 1940-04-30

Family

ID=25723832

Family Applications (1)

Application Number Title Priority Date Filing Date
CH209827D CH209827A (en) 1936-01-28 1937-01-08 Process for the preparation of a thiazolium compound.

Country Status (1)

Country Link
CH (1) CH209827A (en)

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