CH209822A - Process for the preparation of a thiazolium compound. - Google Patents

Process for the preparation of a thiazolium compound.

Info

Publication number
CH209822A
CH209822A CH209822DA CH209822A CH 209822 A CH209822 A CH 209822A CH 209822D A CH209822D A CH 209822DA CH 209822 A CH209822 A CH 209822A
Authority
CH
Switzerland
Prior art keywords
ethyl
preparation
compound
thiazolium compound
thiazolium
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH209822A publication Critical patent/CH209822A/en

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Description

  

  Verfahren zur Darstellung einer     Thiazoliumverbindung.       Das Hauptpatent betrifft die Herstellung  einer durch     antineuritische    Wirkung ausge  zeichneten     Pyrimidylalkylthiazoliurnverbin-          dung.     



  Gegenstand des vorliegenden Patentes ist  ein Verfahren zur Herstellung einer     Thiazo-          liumverbindung,    dadurch gekennzeichnet, dass  man     2-Äthyl-4-amino.-5-chlormethyl-pyr-          imidinhydrochlorid    auf     4-Äthyl-5-oxyäthyl-          thiazol    einwirken lässt. Das so erhaltene  Hydrochlorid des N-(2'-Äthyl-4'-arninopyr       imidyl-[5']-methyl)-4-äthyl-5-oxyäthylthiazo-          liumchlorids    bildet Kristalle vom<B>F.217'.</B>  Die Verbindung zeigt eine starke     antineuri-          tische    Wirksamkeit und soll .therapeutische  Anwendung finden.

           Beispiel:       2,4 g     2-Athyl-4-amirro-5-chlormethyl-pyr-          imidinhydrochlorid    werden mit 3,6 g     4-Äthyl-          5-oxyäthylthiazol        '/s    Stunde auf l20-130    erhitzt. Die Schmelze wird mit Äther ver-    rührt und das zurückbleibende Pulver aus  Alkohol und etwas Wasser umkristallisiert.  Man erhält das Hydrochlorid des N-(2'-Äthyl       4'-aminopyrimidyl-[5']-methyl)-4-äthyl-5-oxy-          äthylthiazoliumchlorids    in Kristallen vom  F. 217  . Die Verbindung zeigt eine starke       antineuritische    Wirksamkeit.



  Process for the preparation of a thiazolium compound. The main patent relates to the production of a pyrimidylalkylthiazolium compound which has an antineuritic effect.



  The subject of the present patent is a process for the production of a thiazolium compound, characterized in that 2-ethyl-4-amino.-5-chloromethyl-pyrimidine hydrochloride is allowed to act on 4-ethyl-5-oxyethyl-thiazole. The hydrochloride of N- (2'-ethyl-4'-aminopyrimidyl- [5 '] -methyl) -4-ethyl-5-oxyethylthiazolium chloride thus obtained forms crystals of <B> F.217'. </ B > The compound shows a strong anti-neuritic effectiveness and is supposed to find therapeutic application.

           Example: 2.4 g of 2-ethyl-4-amirro-5-chloromethyl-pyrimidine hydrochloride are heated to 120-130 per second with 3.6 g of 4-ethyl-5-oxyethylthiazole / s. The melt is stirred with ether and the powder that remains is recrystallized from alcohol and a little water. The hydrochloride of N- (2'-ethyl 4'-aminopyrimidyl- [5 '] - methyl) -4-ethyl-5-oxyethylthiazolium chloride is obtained in crystals of F. 217. The compound shows strong anti-neuritic activity.

Claims (1)

PATENTANSPRUC$: Verfahren zur Herstellung einer Thiazo- liumverbindung, dadurch gekennzeichnet, dass man 2-Äthyl-4-amino-5-chlormethyl-pyrimi- dinhydrochlorid auf 4-Äthyl-5-oxyäthylthiazol einwirken lässt. -Das so erhältliche Hydrochlorid des N- (2'-Äthyl-4'- aminopyrimidyl - [5'] - methyl) - 4- äthyl-5-oxyäthylthiazoliumchlorids bildet Kri stalle vom F. 217 . PATENT CLAIM: Process for the production of a thiazolium compound, characterized in that 2-ethyl-4-amino-5-chloromethyl-pyrimidine hydrochloride is allowed to act on 4-ethyl-5-oxyethylthiazole. The thus obtainable hydrochloride of N- (2'-ethyl-4'-aminopyrimidyl - [5 '] - methyl) -4-ethyl-5-oxyäthylthiazoliumchlorids forms crystals from F. 217.
CH209822D 1936-01-28 1937-01-08 Process for the preparation of a thiazolium compound. CH209822A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE209822X 1936-01-28
CH202663T 1937-01-08

Publications (1)

Publication Number Publication Date
CH209822A true CH209822A (en) 1940-04-30

Family

ID=25723827

Family Applications (1)

Application Number Title Priority Date Filing Date
CH209822D CH209822A (en) 1936-01-28 1937-01-08 Process for the preparation of a thiazolium compound.

Country Status (1)

Country Link
CH (1) CH209822A (en)

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