CH173194A - Process for the production of a vaccine for the active immunization of humans or animals against anaerobic germs. - Google Patents

Process for the production of a vaccine for the active immunization of humans or animals against anaerobic germs.

Info

Publication number
CH173194A
CH173194A CH173194DA CH173194A CH 173194 A CH173194 A CH 173194A CH 173194D A CH173194D A CH 173194DA CH 173194 A CH173194 A CH 173194A
Authority
CH
Switzerland
Prior art keywords
vaccine
humans
production
active immunization
animals against
Prior art date
Application number
Other languages
German (de)
Inventor
Veterinaria A-G Zuerich
Original Assignee
Veterinaria A G Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Veterinaria A G Zuerich filed Critical Veterinaria A G Zuerich
Publication of CH173194A publication Critical patent/CH173194A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Description

  

  Verfahren zur Herstellung eines     Impfstoffes    zur aktiven Immunisierung von       Hensehen    oder Tieren gegen anaerobe     Krankheitskeime.       Zur Überführung von Kulturen lebender  Bakterien in     Impfstoffe    wurden bekanntlich  bisher die Kulturen entweder auf eine be  stimmte Temperatur erhitzt, oder aber mit  Formaldehyd oder ähnlich wirkenden Chemi  kalien versetzt, oder aber wurde der flüssige  Teil des Nährbodens von Bakterienleibern  und Sporen durch Filtration oder     Super-          zentrifugation    befreit, unter Zusatz von  Konservierungsmitteln, um die dauernde Frei  heit von     accidentellen    Keimen zu gewähr  leisten.

   Es hat sich nun gezeigt, dass bei  anaeroben Bakterien an Stelle jener Mittel  und Verfahren mit Vorteil     Sauerstoffabgeber     zu verwenden sind. Dies war     umsoweniger     vorauszusehen, als der einzige bisher durch  Literatur bekannt gewordene Versuch mit  negativem Erfolg verlief (Löwenstein, Wiener  Klinische Wochenschrift 1903). Das V er  fahren gemäss der Erfindung zur Herstellung  eines     Impfstoffes    zur aktiven Immunisierung    von Menschen oder Tieren gegen anaerobe  Krankheitskeime ist dadurch gekennzeichnet,  dass man eine Kultur anaerober Bakterien  mit einem Oxydationsmittel behandelt.  



  <I>Beispiel:</I>  Eine in bekannter Weise hergestellte  Kultur des     Rauschbrandbazillus    wird in       Fleischwasserbouillon    mit 0,20o Wasser  stoffsuperoxyd versetzt. Nach 2 bis 3     stün-          digem    Stehen ist das Produkt ohne weiteres  als     Vakzin    verwendbar.



  Process for the production of a vaccine for the active immunization of hens or animals against anaerobic germs. To convert cultures of living bacteria into vaccines, it is known that the cultures have either been heated to a certain temperature or treated with formaldehyde or similar chemicals, or the liquid part of the culture medium has been removed from bacterial bodies and spores by filtration or supercentrifugation exempted, with the addition of preservatives, in order to guarantee permanent freedom from accidental germs.

   It has now been shown that in the case of anaerobic bacteria, instead of those means and methods, it is advantageous to use oxygen donors. This could not be foreseen as the only attempt so far known through literature was negative (Löwenstein, Wiener Klinische Wochenschrift 1903). The method according to the invention for the preparation of a vaccine for the active immunization of humans or animals against anaerobic germs is characterized in that a culture of anaerobic bacteria is treated with an oxidizing agent.



  <I> Example: </I> A culture of the intoxicating bacillus produced in a known way is mixed with 0.20 ° hydrogen peroxide in meat water broth. After standing for 2 to 3 hours, the product can be used as a vaccine without further ado.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines Impf stoffes zur aktiven Immunisierung von Men schen oder Tieren gegen anaerobe Krank heitskeime, dadurch gekennzeichnet, dass man eine Kultur anaerober Bakterien mit einem Oxydationsmittel behandelt. PATENT CLAIM: Process for the production of a vaccine for the active immunization of humans or animals against anaerobic germs, characterized in that a culture of anaerobic bacteria is treated with an oxidizing agent.
CH173194D 1933-05-27 1933-05-27 Process for the production of a vaccine for the active immunization of humans or animals against anaerobic germs. CH173194A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH173194T 1933-05-27

Publications (1)

Publication Number Publication Date
CH173194A true CH173194A (en) 1934-11-15

Family

ID=4424493

Family Applications (1)

Application Number Title Priority Date Filing Date
CH173194D CH173194A (en) 1933-05-27 1933-05-27 Process for the production of a vaccine for the active immunization of humans or animals against anaerobic germs.

Country Status (1)

Country Link
CH (1) CH173194A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0086071A1 (en) * 1982-02-09 1983-08-17 The Regents Of The University Of California Ozone inactivated organisms as vaccines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0086071A1 (en) * 1982-02-09 1983-08-17 The Regents Of The University Of California Ozone inactivated organisms as vaccines

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