CH163444A - Process for the preparation of l-1-m-oxyphenyl-2-aminopropan-1-ol chlorohydrate. - Google Patents

Process for the preparation of l-1-m-oxyphenyl-2-aminopropan-1-ol chlorohydrate.

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Publication number
CH163444A
CH163444A CH163444DA CH163444A CH 163444 A CH163444 A CH 163444A CH 163444D A CH163444D A CH 163444DA CH 163444 A CH163444 A CH 163444A
Authority
CH
Switzerland
Prior art keywords
oxyphenyl
chlorohydrate
preparation
aminopropan
hydrogen
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH163444A publication Critical patent/CH163444A/en

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  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Herstellung von     1-1-m-Oxyphenyl-2-aminopropau-l-ol-ohlorhydra-t-.            Ge-,enstand    der     vorliegen-den    Erfindung  in<B>n</B>  ist ein Verfahren zur Herstellung von     1-1-m-          Oxyphenyl   <B>-</B> 2<B>-</B>     amino#propan-l-ol-chlorhydrat,     welches dadurch gekennzeichnet ist,     dass     man     1-m-Oxyphenylacetyleatbinel    in Gegen  wart von     Ammchniumehlorid    mit Wasserstoff  in Gegenwart von Katalysatoren der Nickel  gruppe behandelt.  



  <I>Beispiel:</I>  Eine Lösung von<B>16,6</B> er     1-m-Oxyphenyl-          C   <B>en</B>       acetylearbinol    und<B>5,5</B>     gr        Ammoniumehlori.(3     in<B>150</B> cm' 50%igem Alkohol wird mit     Nik-          kel,    und Wasserstoff bei zirka,

  <B>70 '</B>     hydriert.     Nach Entfernen des Katalysators wird der  Alkohol bei vermindertem Druck     abd-estil-          liert        und    der     Rückstan#d    in Wasser und  Äther     aufoenommen.    Die aus der wässerigen  Schicht durch einen     Überschuss    von     Kalium-          earbanat    abgeschiedene Base wird mit Essig-         ester    aufgenommen und nach dem Trocknen  mit Natriumsulfat im Vakuumeingedampft.

    Der Rückstand, in Alkohol gelöst, wird mit  alkoholischer Salzsäure     seliwach        anzgesäuert,     worauf sich das     1-1-m-Oxyphenyl-2-a-mino-          propaii-l-o-l-chlorhydrat    als schwer kristalli  sierende Substanz     abscheid-et.  



  Process for the preparation of 1-1-m-oxyphenyl-2-aminopropau-l-ol-ohlorhydra-t-. The subject matter of the present invention in <B> n </B> is a process for the production of 1-1-m-oxyphenyl <B> - </B> 2 <B> - </B> amino # propan-l-ol chlorohydrate, which is characterized in that 1-m-oxyphenylacetyleatebinel is treated with hydrogen in the presence of catalysts of the nickel group in the presence of ammonium chloride.



  <I> Example: </I> A solution of <B> 16.6 </B> er 1-m-oxyphenyl-C <B> en </B> acetylearbinol and <B> 5.5 </B> gr ammonium malignancy. (3 in <B> 150 </B> cm '50% alcohol is mixed with nickel, and hydrogen at approx.

  <B> 70 '</B> hydrogenated. After removing the catalyst, the alcohol is distilled off under reduced pressure and the residue is taken up in water and ether. The base separated from the aqueous layer by an excess of potassium earbanate is taken up with ethyl acetate and, after drying with sodium sulfate, evaporated in vacuo.

    The residue, dissolved in alcohol, is acidified seliwach with alcoholic hydrochloric acid, whereupon the 1-1-m-oxyphenyl-2-a-minopropaii-l-o-l-chlorohydrate separates out as a substance which is difficult to crystallize.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von 1-1-m- Oxyphonyl-2-amino,pro-pa,n-l-ol-chlorhy-drat, da;durch gekennzeichnet, dass man 1-m-Oxy- phenylacetylearbine,1 in Gegenwart von Am- moniumehlorid mit Wasserstoff in Gegen wart von Katalysatoren der Nickelgruppe behandelt. Claim: Process for the production of 1-1-m-oxyphonyl-2-amino, pro-pa, nl-ol-chlorohydrate, characterized in that 1-m-oxyphenylacetylearbine, 1 in the presence of Am - Monium chloride treated with hydrogen in the presence of catalysts from the nickel group.
CH163444D 1930-09-08 1931-09-07 Process for the preparation of l-1-m-oxyphenyl-2-aminopropan-1-ol chlorohydrate. CH163444A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE163444X 1930-09-08
CH157188T 1931-09-07

Publications (1)

Publication Number Publication Date
CH163444A true CH163444A (en) 1933-08-15

Family

ID=25716908

Family Applications (1)

Application Number Title Priority Date Filing Date
CH163444D CH163444A (en) 1930-09-08 1931-09-07 Process for the preparation of l-1-m-oxyphenyl-2-aminopropan-1-ol chlorohydrate.

Country Status (1)

Country Link
CH (1) CH163444A (en)

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