CH162366A - Process for the preparation of 1-aurothioglucose. - Google Patents
Process for the preparation of 1-aurothioglucose.Info
- Publication number
- CH162366A CH162366A CH162366DA CH162366A CH 162366 A CH162366 A CH 162366A CH 162366D A CH162366D A CH 162366DA CH 162366 A CH162366 A CH 162366A
- Authority
- CH
- Switzerland
- Prior art keywords
- aurothioglucose
- preparation
- parts
- thioglucose
- water
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Description
Verfahren zur Darstellung von 1-Aurothioglucose. Nach Patent 124870 erhält man die thera peutisch wertvolle 1-Aurothioglucose in der Weise, dass rnan auf 1-Thioglucose ein Gold salz einwirken lässt. Es wurde nun gefunden, dass man vorteilhaft auch in der Weise ver fahren kann, dass man ein Alkalisalz der Thioglucose mit einem Goldsalz umsetzt.
<I>Beispiel:</I> 1,62 Teile 1-Natriumthioglucose wird in 50 Teilen Wasser gelöst und unter Rühren allmählich eine Lösung von 5,92 Teilen Ka- liumaurobromid oder 3,03 Teile Goldchlorid in 30 Teilen Wasser bei 6-10 zugetropft.
Es beginnt bald die Ausscheidung der Aurothioglucose. Nachdem alles zugeflossen ist, rührt man noch '/2 Stunde und saugt den ausgeschiedenen Niederschlag ab, wäscht ihn wiederholt mit Wasser gut aus und trocknet ihn durch Waschen mit Alkohol und Äther. Schliesslich wird die Verbindung im Vakuum über Phospborpentogyd bis zur Gewichtskon stanz getrocknet.
Die Eigenschaften der Verbindung und ihr Verwendungszweck sind bereits im Haupt patent beschrieben.
Process for the preparation of 1-aurothioglucose. According to patent 124870, the therapeutically valuable 1-aurothioglucose is obtained in such a way that a gold salt can act on 1-thioglucose. It has now been found that one can also advantageously proceed in such a way that an alkali salt of thioglucose is reacted with a gold salt.
<I> Example: </I> 1.62 parts of 1-sodium thioglucose is dissolved in 50 parts of water and gradually a solution of 5.92 parts of potassium aurobromide or 3.03 parts of gold chloride in 30 parts of water at 6-10 added dropwise.
The excretion of aurothioglucose soon begins. After everything has flowed in, the mixture is stirred for a further 1/2 hour and the precipitate which has separated out is filtered off with suction, washed repeatedly with water and dried by washing with alcohol and ether. Finally, the compound is dried in vacuo over Phospborpentogyd to weight constancy.
The properties of the compound and its intended use are already described in the main patent.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE162366X | 1931-08-03 | ||
| CH124870T | 1932-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH162366A true CH162366A (en) | 1933-06-15 |
Family
ID=25710370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH162366D CH162366A (en) | 1931-08-03 | 1932-06-30 | Process for the preparation of 1-aurothioglucose. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH162366A (en) |
-
1932
- 1932-06-30 CH CH162366D patent/CH162366A/en unknown
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