CH158450A - Process for the preparation of a water-soluble antimony salt. - Google Patents
Process for the preparation of a water-soluble antimony salt.Info
- Publication number
- CH158450A CH158450A CH158450DA CH158450A CH 158450 A CH158450 A CH 158450A CH 158450D A CH158450D A CH 158450DA CH 158450 A CH158450 A CH 158450A
- Authority
- CH
- Switzerland
- Prior art keywords
- quinine
- water
- preparation
- gluconate
- antimony salt
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 4
- 150000001462 antimony Chemical class 0.000 title description 2
- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 claims description 18
- 235000001258 Cinchona calisaya Nutrition 0.000 claims description 9
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 claims description 9
- 229960000948 quinine Drugs 0.000 claims description 9
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims description 6
- 229940050410 gluconate Drugs 0.000 claims description 6
- 125000001880 stiboryl group Chemical group *[Sb](*)(*)=O 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 3
- SZOADBKOANDULT-UHFFFAOYSA-K antimonous acid Chemical compound O[Sb](O)O SZOADBKOANDULT-UHFFFAOYSA-K 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims description 2
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 claims description 2
- 229940007424 antimony trisulfide Drugs 0.000 claims description 2
- NVWBARWTDVQPJD-UHFFFAOYSA-N antimony(3+);trisulfide Chemical compound [S-2].[S-2].[S-2].[Sb+3].[Sb+3] NVWBARWTDVQPJD-UHFFFAOYSA-N 0.000 claims description 2
- 235000012208 gluconic acid Nutrition 0.000 claims description 2
- 239000000174 gluconic acid Substances 0.000 claims description 2
- 229910000037 hydrogen sulfide Inorganic materials 0.000 claims description 2
- 239000002244 precipitate Substances 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- XHKUDCCTVQUHJQ-BILMMMPYSA-N (r)-[(2s,4s,5r)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C([C@H]([C@H](C1)C=C)C2)CN1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 XHKUDCCTVQUHJQ-BILMMMPYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/90—Antimony compounds
- C07F9/902—Compounds without antimony-carbon linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Darstellung eines wasserlöslichen Antimonsalzes. Das vorliegende Verfahren betrifft die Darstellung von Chininantimonylgluconat und ist dadurch gekennzeichnet, dass man Chinin, G-luconsäure und Antimontrihydroxyd auf einander einwirken lässt.
Das bis jetzt unbekannte Chininantimonyl- gluconat ist ein farbloses, sprödes Pulver, welches in Wasser mit bläulicher Fluoreszenz leicht löslich ist. Es soll in der Therapie Verwendung finden. <I>Beispiel:</I> 14,3 gr Chiningluconat, dargestellt durch Neutralisieren von Gluconsäure mit Chinin, werden in 25 cms Wasser gelöst und mit 8,3 gr Antimontrihydroxyd geschüttelt. Durch Zentrifugieren wird von Nichtgelöstem abge trennt und die klare Lösung im Vakuum zur Trockne gebracht.
Man erhält 20,5 gr eines fast farblosen, spröden Pulvers, welches in Wasser mit bläulicher Fluoreszenz leicht löslich ist und beständige Lösungen liefert. Durch Behandeln derselben mit Schwefel wasserstoff wird ein Niederschlag von Anti- montrisulfid erhalten. Das Chininantimonyl- gluconat besitzt die Formel C32Hbo020N2Sb2.
Process for the preparation of a water-soluble antimony salt. The present method relates to the preparation of quinine antimonyl gluconate and is characterized in that quinine, g-luconic acid and antimony trihydroxide are allowed to act on one another.
The hitherto unknown quinine antimonyl gluconate is a colorless, brittle powder which is easily soluble in water with a bluish fluorescence. It should be used in therapy. <I> Example: </I> 14.3 g of quinine gluconate, prepared by neutralizing gluconic acid with quinine, are dissolved in 25 cms of water and shaken with 8.3 g of antimony trihydroxide. Undissolved material is separated off by centrifugation and the clear solution is brought to dryness in vacuo.
This gives 20.5 g of an almost colorless, brittle powder which is easily soluble in water with a bluish fluorescence and which gives stable solutions. By treating them with hydrogen sulfide, a precipitate of antimony trisulfide is obtained. The quinine antimonyl gluconate has the formula C32Hbo020N2Sb2.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE601995T | 1930-07-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH158450A true CH158450A (en) | 1932-11-15 |
Family
ID=34608828
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH155938D CH155938A (en) | 1930-07-13 | 1931-07-08 | Process for the preparation of a water-soluble antimony salt. |
| CH158450D CH158450A (en) | 1930-07-13 | 1931-07-08 | Process for the preparation of a water-soluble antimony salt. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH155938D CH155938A (en) | 1930-07-13 | 1931-07-08 | Process for the preparation of a water-soluble antimony salt. |
Country Status (3)
| Country | Link |
|---|---|
| AT (1) | AT134242B (en) |
| CH (2) | CH155938A (en) |
| DE (1) | DE601995C (en) |
-
1930
- 1930-07-13 DE DE1930601995D patent/DE601995C/en not_active Expired
-
1931
- 1931-07-02 AT AT134242D patent/AT134242B/en active
- 1931-07-08 CH CH155938D patent/CH155938A/en unknown
- 1931-07-08 CH CH158450D patent/CH158450A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE601995C (en) | 1934-08-29 |
| AT134242B (en) | 1933-07-25 |
| CH155938A (en) | 1932-07-15 |
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