CH125135A - Process for the preparation of 2-styryl-4-amino-6-ethoxy-quinoline. - Google Patents

Process for the preparation of 2-styryl-4-amino-6-ethoxy-quinoline.

Info

Publication number
CH125135A
CH125135A CH125135DA CH125135A CH 125135 A CH125135 A CH 125135A CH 125135D A CH125135D A CH 125135DA CH 125135 A CH125135 A CH 125135A
Authority
CH
Switzerland
Prior art keywords
styryl
ethoxy
amino
quinoline
preparation
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH125135A publication Critical patent/CH125135A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Darstellung von     2-Styryl-4-amino-6-äthogy-ehinolin.       Gegenstand dieser     Erfindung    ist ein Ver  fahren zur Darstellung von     2-Styryl-4-amino-    .       6-äthoxy-chirroliri,    welches dadurch     gekenn-          zeichnetist,        dassman2-Styryl-4-brom-6-äthoxy-          chinolin    mit Ammoniak umsetzt.  



  <I>Beispiel:</I>  1 Teil     2-Styryl-4-brorri-6-äthoxy-chinolin     wird mit 8 Teilen gesättigtem alkoholischen  Ammoniak 8 Stunden im Rohr auf 200   er  hitzt. Nach dem Eindampfen der Lösung  wird reit Essigsäure angesäuert und die durch  Filtrieren vom unveränderten Bromprodukt  ' befreite Lösung mit Ammoniak versetzt, wo  durch das     2-Styryl-4-amino-6-äthoxy-chinolirr       von den im Hauptpatent angegebenen Eigen  schaften ausfällt.



  Process for the preparation of 2-styryl-4-amino-6-ethogy-ehinoline. The subject of this invention is a process for the preparation of 2-styryl-4-amino-. 6-ethoxy-chirroliri, which is characterized in that 2-styryl-4-bromo-6-ethoxy-quinoline is reacted with ammonia.



  <I> Example: </I> 1 part of 2-styryl-4-brorri-6-ethoxy-quinoline is heated to 200 for 8 hours with 8 parts of saturated alcoholic ammonia. After evaporation of the solution, acetic acid is acidified and ammonia is added to the solution, freed from the unchanged bromine product by filtration, where the 2-styryl-4-amino-6-ethoxy-quinolirr of the properties specified in the main patent fails.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung von 2-Styryl- 4-amino-6-äthoxy-cbinolin, dadurch gekenn zeichnet, dass man 2-Styryl-4-brom-6-äthoxy- chinolin mit Ammoniak umsetzt. Die Verbindung schmilzt bei 212' und bildet mit Milchsäure, Glykolsäure und China säure in Wasser leicht lösliche Salze. Sie besitzt eine stark bactericide Wirkung. Die Verbindung soll als solche oder in Form ihrer Salze in der Therapie Verwendung finden. PATENT CLAIM: Process for the preparation of 2-styryl-4-amino-6-ethoxy-cbinoline, characterized in that 2-styryl-4-bromo-6-ethoxy-quinoline is reacted with ammonia. The compound melts at 212 'and forms salts with lactic acid, glycolic acid and quinic acid which are easily soluble in water. It has a strong bactericidal effect. The compound is intended to be used as such or in the form of its salts in therapy.
CH125135D 1926-09-07 1926-09-07 Process for the preparation of 2-styryl-4-amino-6-ethoxy-quinoline. CH125135A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH125135T 1926-09-07
CH124025T 1926-09-07

Publications (1)

Publication Number Publication Date
CH125135A true CH125135A (en) 1928-04-02

Family

ID=25710176

Family Applications (1)

Application Number Title Priority Date Filing Date
CH125135D CH125135A (en) 1926-09-07 1926-09-07 Process for the preparation of 2-styryl-4-amino-6-ethoxy-quinoline.

Country Status (1)

Country Link
CH (1) CH125135A (en)

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