CH119924A - Method for representing an unbalanced arsenic compound. - Google Patents

Method for representing an unbalanced arsenic compound.

Info

Publication number
CH119924A
CH119924A CH119924DA CH119924A CH 119924 A CH119924 A CH 119924A CH 119924D A CH119924D A CH 119924DA CH 119924 A CH119924 A CH 119924A
Authority
CH
Switzerland
Prior art keywords
sep
arsenic compound
unbalanced
representing
acid
Prior art date
Application number
Other languages
German (de)
Inventor
Deutsche Gold-Und Sil Roessler
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa filed Critical Degussa
Publication of CH119924A publication Critical patent/CH119924A/en

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Description

  

  Verfahren zur Darstellung einer unsymmetrischen     Arsenoverbindung.       Nach dem Hauptpatent gelangt man zu  einer unsymmetrischen     Arsenoverbindung,     welche eine nicht zyklisch gebundene     Kar-          bonylgruppe    enthält, dadurch, dass man     3-          Oxy-l-acetophenon-4-arsinsäuresemikarbazon     und     p-Phenylglyzinarsinsäure    zusammen der  Reduktion unterwirft.  



  Nach dem vorliegenden Zusatzpatent  wird derart verfahren, dass     3-Oxy-l-aceto-          phenon-4-arsinsäuresemikarbazon    und     3-          Phenoxyessigsäur    e-1-     acetophenon    - 4 -     arsin-          säuresemika.rbazon    folgender Konstitution:  
EMI0001.0015     
    zusammen der Reduktion unterworfen wer  den.  



  Die Durchführung des Verfahrens erfolgt  im allgemeinen so, dass man eine Lösung  oder     Suspension,    die     äquimolekulare    oder an-    nähernd     äquimolekulare    Mengen der Reak  tionskomponenten enthält, mit geeigneten Re  duktionsmitteln, wie zum Beispiel     Hydro-          sulfiten,        unterphosphorige    Säure oder deren  Salze, behandelt.  



       Beispiel:     3,2     gr        3-Oxy-l-acetophenon-4-arsinsäure-          semikarbazon    und 3,8     gr        3-Phenoxyessig-          säure    -     1-acetophenon-4-arsinsäuresemikarba-          zon    werden in etwa 140     cm3    Wasser von an  nähernd 65   suspendiert und die Suspension  unter Rühren und     Konstanthalten    der Tem  peratur möglichst bei     Luftabschluss    mit 28     gr          Nätriumhydrosulfit    versetzt.

   Nach 20 Mi  nuten Rühren bei der angegebenen Tempera  tur wird das ausgeschiedene gelbe     Arseno-          benzol        abgesogen,    gewaschen und getrocknet.  Es zersetzt sich im     Kapillarrohr,    erhitzt je  nach Art des     Erhitzens    über 200'.  



  Das Präparat ist in Alkalien leicht lös  lich und soll pharmazeutische Verwendung.  finden, speziell bei     Lues    angewandt werden.



  Method for representing an unbalanced arsenic compound. According to the main patent, an unsymmetrical arsenic compound which contains a non-cyclically bonded carbonyl group is obtained by subjecting 3-oxy-1-acetophenone-4-arsinic semicarbazone and p-phenylglycinarsinic acid to the reduction.



  According to the present additional patent, the procedure is such that 3-oxy-l-aceto-phenone-4-arsinic acid semicarbazone and 3-phenoxyacetic acid e-1-acetophenone - 4 - arsinic acid semicarbazone of the following constitution:
EMI0001.0015
    together are subjected to the reduction.



  The process is generally carried out by treating a solution or suspension which contains equimolecular or approximately equimolecular amounts of the reaction components with suitable reducing agents, such as, for example, hydrosulfites, hypophosphorous acid or their salts.



       Example: 3.2 g of 3-oxy-1-acetophenone-4-arsinic acid semicarbazone and 3.8 g of 3-phenoxyacetic acid - 1-acetophenone-4-arsinic acid semicarbazone are suspended in about 140 cm3 of water of approx. 65 and 28 grams of sodium hydrosulfite are added to the suspension while stirring and keeping the temperature constant, if possible with the exclusion of air.

   After stirring for 20 minutes at the stated temperature, the precipitated yellow arsenobenzene is suctioned off, washed and dried. It decomposes in the capillary tube and, depending on the type of heating, heats up over 200 '.



  The preparation is easily soluble in alkalis and is intended for pharmaceutical use. can be used especially for syphilis.

Claims (1)

EMI0002.0001 PATENTANSPRUCH: <tb> Verfahren <SEP> zur <SEP> Darstellung <SEP> einer <SEP> unsym metrischen <SEP> Arsenoverbindung, <SEP> dadurch <SEP> ge kennzeielinet, <SEP> dass <SEP> man <SEP> 3-Phenoxyessigsätire 1.-aeetophenon-4-arsinsäuresemikarbazon EMI0002.0002 EMI0002.0003 und <SEP> 3-Ozy--l-aeetophenon-4-arsinsä.uresemi karba <SEP> zon <SEP> zusammen <SEP> der <SEP> Reduktion <SEP> unter wir <SEP> f <SEP> t. <tb> Das <SEP> Präparat <SEP> ist <SEP> in <SEP> Alkalien <SEP> leieht <SEP> lös lieli <SEP> und <SEP> soll <SEP> pha.rnia.zeutisehe <SEP> Verwendung <tb> finden, <SEP> speziell <SEP> bei <SEP> Lues <SEP> angewandt <SEP> werden. EMI0002.0001 PATENT CLAIM: <tb> Method <SEP> for <SEP> representation <SEP> of a <SEP> asymmetrical <SEP> arsenic compound, <SEP> thereby <SEP> marked, <SEP> that <SEP> one <SEP> 3-Phenoxyessigsätire 1.-aeetophenone-4-arsinic acid semicarbazone EMI0002.0002 EMI0002.0003 and <SEP> 3-Ozy - l-aeetophenon-4-arsinsä.uresemi karba <SEP> zon <SEP> together <SEP> the <SEP> reduction <SEP> under we <SEP> f <SEP> t. <tb> The <SEP> preparation <SEP> is <SEP> in <SEP> alkalis <SEP> leans <SEP>lös lieli <SEP> and <SEP> should <SEP> pha.rnia.zeutisehe <SEP> use Find <tb>, <SEP> especially <SEP> with <SEP> Lues <SEP> are used <SEP>.
CH119924D 1923-12-04 1924-11-19 Method for representing an unbalanced arsenic compound. CH119924A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AT119924X 1923-12-04
AT240124X 1924-01-24
CH115212T 1924-11-19

Publications (1)

Publication Number Publication Date
CH119924A true CH119924A (en) 1927-05-02

Family

ID=27151225

Family Applications (1)

Application Number Title Priority Date Filing Date
CH119924D CH119924A (en) 1923-12-04 1924-11-19 Method for representing an unbalanced arsenic compound.

Country Status (1)

Country Link
CH (1) CH119924A (en)

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