CA995673A - Process for preparing 2-amino and 4-amino-quinazolines - Google Patents

Process for preparing 2-amino and 4-amino-quinazolines

Info

Publication number
CA995673A
CA995673A CA180,089A CA180089A CA995673A CA 995673 A CA995673 A CA 995673A CA 180089 A CA180089 A CA 180089A CA 995673 A CA995673 A CA 995673A
Authority
CA
Canada
Prior art keywords
amino
quinazolines
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA180,089A
Other languages
English (en)
Inventor
John C. Danilewicz
John E.G. Kemp
James R. Wright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp SRL
Original Assignee
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp SRL filed Critical Pfizer Corp SRL
Application granted granted Critical
Publication of CA995673A publication Critical patent/CA995673A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA180,089A 1972-09-09 1973-08-31 Process for preparing 2-amino and 4-amino-quinazolines Expired CA995673A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4199272A GB1383409A (en) 1972-09-09 1972-09-09 Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
CA995673A true CA995673A (en) 1976-08-24

Family

ID=10422335

Family Applications (1)

Application Number Title Priority Date Filing Date
CA180,089A Expired CA995673A (en) 1972-09-09 1973-08-31 Process for preparing 2-amino and 4-amino-quinazolines

Country Status (17)

Country Link
US (1) US3960861A (cg-RX-API-DMAC7.html)
JP (1) JPS4985078A (cg-RX-API-DMAC7.html)
AR (1) AR203373A1 (cg-RX-API-DMAC7.html)
AT (1) AT330785B (cg-RX-API-DMAC7.html)
BE (1) BE804558A (cg-RX-API-DMAC7.html)
CA (1) CA995673A (cg-RX-API-DMAC7.html)
DE (2) DE2366106C2 (cg-RX-API-DMAC7.html)
DK (1) DK131725C (cg-RX-API-DMAC7.html)
ES (1) ES418612A1 (cg-RX-API-DMAC7.html)
FR (1) FR2198751B1 (cg-RX-API-DMAC7.html)
GB (1) GB1383409A (cg-RX-API-DMAC7.html)
IE (1) IE38318B1 (cg-RX-API-DMAC7.html)
IN (2) IN139088B (cg-RX-API-DMAC7.html)
LU (1) LU68373A1 (cg-RX-API-DMAC7.html)
NL (1) NL161152C (cg-RX-API-DMAC7.html)
SU (1) SU555850A3 (cg-RX-API-DMAC7.html)
ZA (1) ZA735660B (cg-RX-API-DMAC7.html)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4044136A (en) * 1972-09-09 1977-08-23 Pfizer Inc. Aminoquinazoline therapeutic agents
GR79603B (cg-RX-API-DMAC7.html) * 1982-07-24 1984-10-31 Pfizer
US4555569A (en) * 1983-06-28 1985-11-26 Ciba-Geigy Corporation Chromogenic quinazolines
US5444062A (en) * 1990-11-06 1995-08-22 Pfizer Inc. Quinazolines derivatives for enhancing antitumor activity
KR0144833B1 (ko) * 1992-12-28 1998-07-15 김태훈 신규의 퀴나졸린 유도체 및 그의 제조방법
DE4338396A1 (de) * 1993-11-10 1995-05-11 Basf Ag N-Substituierte Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
IT1286302B1 (it) * 1996-04-10 1998-07-08 Rotta Research Lab Chinazoline-4-amino-2-(piperidino-1-il-4-sostituite) ad attivita' anti-ipertensiva, procedimento per la loro preparazione e loro uso
IN188411B (cg-RX-API-DMAC7.html) 1997-03-27 2002-09-21 Yuhan Corp
KR100272471B1 (ko) 1998-11-17 2000-11-15 김선진 신규의 피리미딘 유도체 및 그의 제조방법
US6900220B2 (en) 2001-01-02 2005-05-31 Syntex (U.S.A.) Llc Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists
AU2003281346B2 (en) * 2002-07-05 2007-04-05 F. Hoffmann-La Roche Ag Quinazoline derivatives
DE602007011773D1 (de) * 2006-08-04 2011-02-17 Merz Pharma Gmbh & Co Kgaa Substituierte pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin
US8871756B2 (en) * 2011-08-11 2014-10-28 Hoffmann-La Roche Inc. Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease
WO2015018797A2 (en) * 2013-08-05 2015-02-12 Haplogen Gmbh Antiviral compounds
AR099134A1 (es) * 2014-01-24 2016-06-29 Hoffmann La Roche Procedimiento para la preparación de n-[(3-aminooxetán-3-il)metil]-2-(1,1-dioxo-3,5-dihidro-1,4-benzotiazepín-4-il)-6-metil-quinazolín-4-amina
CN107635999B (zh) 2015-05-20 2020-09-25 豪夫迈·罗氏有限公司 用于治疗脊髓性肌萎缩的化合物
WO2017009316A1 (en) 2015-07-16 2017-01-19 F. Hoffmann-La Roche Ag Crystalline forms of n-[(3-amino-3-oxetanyl)methyl]-2-(2,3-dihydro-1,1 -dioxido-1,4-benzothiazepin-4(5 h)-yl)-6-methyl-4-quinazolinamine for the treatment of respiratory syncytial virus (rsv) infections
CA3002494C (en) 2015-11-12 2021-01-12 F. Hoffmann-La Roche Ag Compositions for treating spinal muscular atrophy
CN108697709A (zh) 2015-12-10 2018-10-23 Ptc医疗公司 用于治疗亨廷顿病的方法
EP3386978B1 (en) 2015-12-10 2021-01-27 H. Hoffnabb-La Roche Ag Bridged piperidine derivatives
FR3061494B1 (fr) 2016-12-29 2020-07-03 Arkema France Procede de synthese de dithiocarbamates cycliques fonctionnalises
WO2018226622A1 (en) 2017-06-05 2018-12-13 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
EP3645121B8 (en) 2017-06-28 2025-06-18 PTC Therapeutics, Inc. Methods for treating huntington's disease
BR112019027717A2 (pt) 2017-06-28 2020-07-28 Ptc Therapeutics, Inc. métodos para tratar a doença de huntington
CA3094703A1 (en) 2018-03-27 2019-10-03 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
JP7421507B2 (ja) 2018-06-27 2024-01-24 ピーティーシー セラピューティクス， インコーポレイテッド ハンチントン病を処置するためのヘテロ環式およびヘテロアリール化合物
CN112805280B (zh) 2018-06-27 2024-12-06 Ptc医疗公司 用于治疗亨廷顿氏病的杂芳基化合物
WO2020005882A1 (en) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2945859A (en) * 1960-07-19 Diaminoquinazolines and method of
BE501634A (cg-RX-API-DMAC7.html) * 1950-03-02
US3155572A (en) * 1959-04-13 1964-11-03 Merck & Co Inc Compositions and methods for treating coccidiosis
GB1062357A (en) * 1965-03-23 1967-03-22 Pfizer & Co C Quinazolone derivatives
GB1131126A (en) * 1966-03-10 1968-10-23 Pfizer Ltd 2-vinyl-1,4-dihydroquinazoline derivatives
US3511836A (en) * 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
US3637701A (en) * 1969-03-03 1972-01-25 Sandoz Ag Certain nitrate derivatives of 4-aminoquinazolines
US3635979A (en) * 1969-09-29 1972-01-18 Pfizer Certain 6- and/or 7-alkoxy-substituted-2 4-bis(disubstituted amino) quinazolines
US3669968A (en) * 1970-05-21 1972-06-13 Pfizer Trialkoxy quinazolines

Also Published As

Publication number Publication date
AU5960673A (en) 1975-02-27
IN141109B (cg-RX-API-DMAC7.html) 1977-01-22
DE2366106B1 (de) 1979-06-21
FR2198751A1 (cg-RX-API-DMAC7.html) 1974-04-05
IE38318B1 (en) 1978-02-15
US3960861A (en) 1976-06-01
DE2366106C2 (de) 1980-02-14
GB1383409A (en) 1974-02-12
LU68373A1 (cg-RX-API-DMAC7.html) 1975-05-21
AR203373A1 (es) 1975-09-08
ATA774573A (de) 1975-10-15
JPS4985078A (cg-RX-API-DMAC7.html) 1974-08-15
IN139088B (cg-RX-API-DMAC7.html) 1976-05-08
AT330785B (de) 1976-07-26
IE38318L (en) 1974-03-09
BE804558A (fr) 1974-03-06
DE2345064B2 (de) 1979-03-08
NL161152C (nl) 1980-01-15
FR2198751B1 (cg-RX-API-DMAC7.html) 1977-01-28
SU555850A3 (ru) 1977-04-25
DK131725B (da) 1975-08-25
DE2345064C3 (de) 1979-10-25
DK131725C (da) 1976-01-26
NL7312350A (cg-RX-API-DMAC7.html) 1974-03-12
NL161152B (nl) 1979-08-15
ZA735660B (en) 1974-07-31
DE2345064A1 (de) 1974-04-11
ES418612A1 (es) 1976-07-16

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