CA981265A - 3-amino-1,2,4-benzotriazine-1,4-di-n-oxides and processes for their preparation and use - Google Patents

3-amino-1,2,4-benzotriazine-1,4-di-n-oxides and processes for their preparation and use

Info

Publication number
CA981265A
CA981265A CA162,047A CA162047A CA981265A CA 981265 A CA981265 A CA 981265A CA 162047 A CA162047 A CA 162047A CA 981265 A CA981265 A CA 981265A
Authority
CA
Canada
Prior art keywords
benzotriazine
oxides
amino
processes
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA162,047A
Other languages
English (en)
Other versions
CA162047S (en
Inventor
Florin Seng
Karl G. Metzger
Kurt Ley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of CA981265A publication Critical patent/CA981265A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/168—Steroids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/184—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fodder In General (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Crushing And Grinding (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA162,047A 1972-02-01 1973-01-25 3-amino-1,2,4-benzotriazine-1,4-di-n-oxides and processes for their preparation and use Expired CA981265A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2204574A DE2204574A1 (de) 1972-02-01 1972-02-01 Verfahren zur herstellung von 3-aminobenzo-1,2,4-triazin-di-n-oxiden (1,4)

Publications (1)

Publication Number Publication Date
CA981265A true CA981265A (en) 1976-01-06

Family

ID=5834640

Family Applications (1)

Application Number Title Priority Date Filing Date
CA162,047A Expired CA981265A (en) 1972-02-01 1973-01-25 3-amino-1,2,4-benzotriazine-1,4-di-n-oxides and processes for their preparation and use

Country Status (28)

Country Link
US (1) US3868371A (uk)
JP (2) JPS4881881A (uk)
AR (1) AR193463A1 (uk)
AT (1) AT322559B (uk)
AU (1) AU464773B2 (uk)
BE (1) BE794742A (uk)
BG (1) BG22396A3 (uk)
CA (1) CA981265A (uk)
CH (1) CH576458A5 (uk)
CS (1) CS183675B2 (uk)
DD (1) DD103897A5 (uk)
DE (1) DE2204574A1 (uk)
DK (1) DK132408C (uk)
ES (1) ES411154A1 (uk)
FR (1) FR2181701B1 (uk)
GB (1) GB1373324A (uk)
GT (1) GT198062785A (uk)
HU (1) HU165299B (uk)
IE (1) IE37169B1 (uk)
IL (1) IL41426A (uk)
LU (1) LU66931A1 (uk)
NL (1) NL7301245A (uk)
NO (1) NO136096C (uk)
PL (1) PL79604B1 (uk)
RO (1) RO62861A (uk)
SE (1) SE393612B (uk)
SU (2) SU505329A3 (uk)
ZA (1) ZA73702B (uk)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3991189A (en) * 1972-11-15 1976-11-09 Bayer Aktiengesellschaft Microbiocidal methods and compositions using substituted 1,2,4-triazine-1,4-di-N-oxide derivatives
SE7501624L (uk) * 1974-03-15 1975-09-16 Ciba Geigy Ag
US4247691A (en) * 1977-02-22 1981-01-27 Ciba-Geigy Corporation 1,2,4-Benzotriazine-1,4-di-N-oxides
SU997646A1 (ru) * 1978-11-27 1983-02-23 Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвсср Кормова добавка
US5175287A (en) * 1986-09-25 1992-12-29 S R I International Process for preparing 1,2,4-benzotriazine oxides
US5616584A (en) 1986-09-25 1997-04-01 Sri International 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents
EP0478545B1 (en) * 1989-09-18 1999-08-11 Sri International 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents
US5672702A (en) * 1995-12-04 1997-09-30 Sanofi Process for preparing 3 amino 1, 2, 4-benzotriazine dioxide
WO2003042192A1 (en) * 2001-11-13 2003-05-22 Sanofi-Synthelabo Preparation of 3-amino-1,2,4-benzotriazine dioxide
US20090136521A1 (en) * 2005-10-03 2009-05-28 Genetix Pharmaceuticals , Inc. Method for Selectively Depleting Hypoxic Cells
WO2008033466A2 (en) * 2006-09-14 2008-03-20 Combinatorx (Singapore) Pre. Ltd. Compositions and methods for treatment of viral diseases
US20090076011A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched tirapazamine
JP2015500295A (ja) * 2011-12-07 2015-01-05 エスアールアイ インターナショナルＳＲＩ Ｉｎｔｅｒｎａｔｉｏｎａｌ ヒト結核菌を標的とする医薬としてのベンゾトリアジンオキサイド類
CN102603783B (zh) * 2012-03-16 2014-09-03 张俏男 一种靶向抗恶性肿瘤的药物及其制备方法
EP4201403A1 (en) 2021-12-21 2023-06-28 Som Innovation Biotech, S.L. Compounds tirapazamine and quazinone for use in the treatment of gm2 gangliosidoses

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1007331A (en) * 1960-12-01 1965-10-13 Fisons Pest Control Ltd Quinazolin-3-oxides and benzo-1,2,3-triazine-3-oxides

Also Published As

Publication number Publication date
US3868371A (en) 1975-02-25
SU505329A3 (ru) 1976-02-28
HU165299B (uk) 1974-08-28
NL7301245A (uk) 1973-08-03
SE393612B (sv) 1977-05-16
DE2204574A1 (de) 1973-08-09
CS183675B2 (en) 1978-07-31
IL41426A (en) 1976-06-30
AT322559B (de) 1975-05-26
NO136096C (no) 1977-07-20
FR2181701B1 (uk) 1976-10-22
FR2181701A1 (uk) 1973-12-07
SU447888A3 (ru) 1974-10-25
LU66931A1 (uk) 1973-04-02
AU5162073A (en) 1974-08-01
IE37169B1 (en) 1977-05-25
DD103897A5 (uk) 1974-02-12
IE37169L (en) 1973-08-01
NO136096B (uk) 1977-04-12
JPS4882017A (uk) 1973-11-02
JPS4881881A (uk) 1973-11-01
PL79604B1 (uk) 1975-06-30
DK132408B (da) 1975-12-01
IL41426A0 (en) 1973-03-30
BG22396A3 (bg) 1977-02-20
GT198062785A (es) 1981-09-19
CH576458A5 (uk) 1976-06-15
BE794742A (fr) 1973-07-30
AU464773B2 (en) 1975-09-04
ES411154A1 (es) 1976-03-16
DK132408C (da) 1976-05-03
ZA73702B (en) 1973-10-31
GB1373324A (en) 1974-11-13
AR193463A1 (es) 1973-04-23
RO62861A (fr) 1977-11-15

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