CA957942A - Flowable pancreatin preparation of low germ content, and a process for its manufacture - Google Patents

Flowable pancreatin preparation of low germ content, and a process for its manufacture

Info

Publication number
CA957942A
CA957942A CA118,727A CA118727A CA957942A CA 957942 A CA957942 A CA 957942A CA 118727 A CA118727 A CA 118727A CA 957942 A CA957942 A CA 957942A
Authority
CA
Canada
Prior art keywords
flowable
manufacture
germ content
low germ
pancreatin preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA118,727A
Other languages
English (en)
Inventor
Horst Stolte
Hans Hess
Guenther Mueller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of CA957942A publication Critical patent/CA957942A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/94—Pancreatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/98—Preparation of granular or free-flowing enzyme compositions

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA118,727A 1970-07-23 1971-07-21 Flowable pancreatin preparation of low germ content, and a process for its manufacture Expired CA957942A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1117070 1970-07-23

Publications (1)

Publication Number Publication Date
CA957942A true CA957942A (en) 1974-11-19

Family

ID=4370762

Family Applications (1)

Application Number Title Priority Date Filing Date
CA118,727A Expired CA957942A (en) 1970-07-23 1971-07-21 Flowable pancreatin preparation of low germ content, and a process for its manufacture

Country Status (10)

Country Link
US (1) US3844891A (enExample)
AU (1) AU3151071A (enExample)
BE (1) BE770323A (enExample)
CA (1) CA957942A (enExample)
DE (1) DE2135025A1 (enExample)
DK (1) DK129291B (enExample)
FR (1) FR2103164A5 (enExample)
GB (1) GB1342409A (enExample)
NL (1) NL7110132A (enExample)
ZA (1) ZA714795B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2512746C3 (de) * 1975-03-22 1980-04-24 Kali-Chemie Pharma Gmbh, 3000 Hannover Verfahren zur Herstellung von keimarmem, faserfreiem Pankreatin
FR2422720A2 (fr) * 1977-04-26 1979-11-09 Elf Aquitaine Separation et purification de proteines par chromatographie
DE2923279C2 (de) * 1979-06-08 1987-07-09 Kali-Chemie Pharma Gmbh, 3000 Hannover Verfahren zur Herstellung von Pankreatin-Pellets und diese enthaltende Arzneimittel
US5861291A (en) * 1997-02-24 1999-01-19 Biozymes Inc. Method for producing pancreatin which contains low amounts of residual organic solvent and product thereof
KR100367659B1 (ko) * 2000-05-08 2003-01-14 주식회사 바이넥스 선택적 안정화제의 첨가에 따른 자가분해(autolysis)를 통한 고역가 판크레아틴의 제조방법
IT1319655B1 (it) 2000-11-15 2003-10-23 Eurand Int Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
US7153504B2 (en) * 2004-07-30 2006-12-26 Can Technologies, Inc. Stabilized pancreas product
TR201808840T4 (tr) 2007-02-20 2018-07-23 Allergan Pharmaceuticals Int Ltd Stabil sindirim enzimi bileşimleri.
DE102007044100A1 (de) * 2007-09-14 2009-03-19 Nordmark Arzneimittel Gmbh & Co. Kg Verfahren zur Reduktion der Viren- und Mikroorganismen-Belastung feststoffhaltiger biologischer Extrakte
DE202008003806U1 (de) 2007-09-14 2009-02-12 Nordmark Arzneimittel Gmbh & Co. Kg Extrakt für die Herstellung von pharmazeutischen Therapeutika und dessen Verwendung als Nahrungs- oder Lebensmittel oder Nahrungsergänzungsmittel
US10087493B2 (en) * 2008-03-07 2018-10-02 Aptalis Pharma Canada Ulc Method for detecting infectious parvovirus in pharmaceutical preparations
PL2295086T3 (pl) * 2008-11-03 2012-09-28 Nordmark Arzneimittel Gmbh & Co Kg Sposób zmniejszania skażenia pankreatyny wirusami i drobnoustrojami
AU2011309763B2 (en) 2010-10-01 2015-08-13 Allergan Therapeutics LLC Enteric coated, low- strength pancrelipase formulations
EP2741766B1 (en) 2011-08-08 2015-10-07 Aptalis Pharma Limited Method for dissolution testing of solid compositions containing digestive enzymes
CN106163544A (zh) 2013-08-09 2016-11-23 阿勒根制药国际有限公司 适于经肠施用的消化酶组合物
EP3157568A1 (en) 2014-06-19 2017-04-26 Aptalis Pharma Limited Methods for removing viral contaminants from pancreatic extracts

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2503313A (en) * 1947-04-14 1950-04-11 Levin Ezra Production of dried, defatted enzymatic material
US2922749A (en) * 1953-07-17 1960-01-26 Miles Lab Enzymes

Also Published As

Publication number Publication date
DE2135025A1 (de) 1972-01-27
AU3151071A (en) 1973-01-25
GB1342409A (en) 1974-01-03
ZA714795B (en) 1972-04-26
DK129291B (da) 1974-09-23
FR2103164A5 (enExample) 1972-04-07
DK129291C (enExample) 1975-02-10
BE770323A (fr) 1972-01-24
US3844891A (en) 1974-10-29
NL7110132A (enExample) 1972-01-25

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