CA953725A - Isothioureas and their derivatives - Google Patents

Isothioureas and their derivatives

Info

Publication number
CA953725A
CA953725A CA096,673A CA96673A CA953725A CA 953725 A CA953725 A CA 953725A CA 96673 A CA96673 A CA 96673A CA 953725 A CA953725 A CA 953725A
Authority
CA
Canada
Prior art keywords
isothioureas
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA096,673A
Other languages
English (en)
Other versions
CA96673S (en
Inventor
James W. Black
Graham J. Durant
Charon R. Ganellin
John C. Emmett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Priority to CA197,880A priority Critical patent/CA987592A/en
Application granted granted Critical
Publication of CA953725A publication Critical patent/CA953725A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA096,673A 1969-10-29 1970-10-27 Isothioureas and their derivatives Expired CA953725A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA197,880A CA987592A (en) 1969-10-29 1974-04-19 Histamine inhibiting compositions containing (s-(2-(4(5)-imidazolyl)ethyl) isothiourea

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5289069 1969-10-29

Publications (1)

Publication Number Publication Date
CA953725A true CA953725A (en) 1974-08-27

Family

ID=10465720

Family Applications (1)

Application Number Title Priority Date Filing Date
CA096,673A Expired CA953725A (en) 1969-10-29 1970-10-27 Isothioureas and their derivatives

Country Status (9)

Country Link
JP (1) JPS4917262B1 (de)
BE (1) BE758145A (de)
CA (1) CA953725A (de)
DE (1) DE2052692A1 (de)
FR (1) FR2070177B1 (de)
GB (1) GB1296544A (de)
IE (1) IE34665B1 (de)
SE (1) SE390303B (de)
ZA (1) ZA707150B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA938556A (en) * 1970-06-25 1973-12-18 Smith Kline And French Laboratories Limited Pharmaceutical compositions containing thiourea derivatives
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
GB1397436A (en) * 1972-09-05 1975-06-11 Smith Kline French Lab Heterocyclic n-cyanoguinidines
NZ186965A (en) 1977-04-20 1980-02-21 Ici Ltd Guanidino derivatives and pharmaceutical compositions
US4262125A (en) * 1979-07-23 1981-04-14 American Home Products Corporation (1H-Imidazol-5-ylmethyl)isothioureas
IT1201523B (it) * 1982-05-18 1989-02-02 Angeli Inst Spa Eterociclilfenilfomramidine,processi per la loro preparazione e loro uso farmaceutico
US4520025A (en) * 1982-07-21 1985-05-28 William H. Rorer, Inc. Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses
FR2660862B1 (fr) * 1990-04-13 1994-09-23 Bioprojet Soc Civ Application therapeutique de derives de l'histamine, nouveau derive de l'histamine et utilisation de ces derives pour la preparation de medicaments.
US5321039A (en) * 1990-04-13 1994-06-14 Societe Civile Bioprojet Method of inducing a histamine agonist action on H2 receptors
NL9100365A (nl) * 1991-02-27 1992-09-16 Seed Capital Investments Imidazoolderivaten met agonistische of antagonistische activiteit op de histamine h3-receptor.
AU662135B2 (en) * 1991-02-27 1995-08-24 Seed Capital Investments (Sci) B.V. Imidazole-derivatives having agonistic or antagonistic activity on the histamine H3-receptor
GB0404434D0 (en) * 2004-02-27 2004-03-31 Novartis Ag Organic compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2548746A (en) * 1947-10-10 1951-04-10 Sharp & Dohme Inc S-(4-thiazolylmethyl)-isothioureas
IL25931A (en) * 1965-07-07 1972-01-27 Merck & Co Inc 4- or 5-nitroimidazole - and 5,6-dihydroimidazole [A-2,1] pyrrole-7-il-carbamates and pseudo-thiourea new imidazoles and preparation

Also Published As

Publication number Publication date
DE2052692A1 (de) 1971-05-06
GB1296544A (de) 1972-11-15
SE390303B (sv) 1976-12-13
JPS4917262B1 (de) 1974-04-27
FR2070177B1 (de) 1974-10-11
IE34665B1 (en) 1975-07-09
BE758145A (fr) 1971-04-28
IE34665L (en) 1971-04-29
ZA707150B (en) 1971-07-28
FR2070177A1 (de) 1971-09-10

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