CA934758A - Process for the preparation of unsymmetrical 1,4-dihydropyridine 3,5-dicarboxylates - Google Patents
Process for the preparation of unsymmetrical 1,4-dihydropyridine 3,5-dicarboxylatesInfo
- Publication number
- CA934758A CA934758A CA139293A CA139293A CA934758A CA 934758 A CA934758 A CA 934758A CA 139293 A CA139293 A CA 139293A CA 139293 A CA139293 A CA 139293A CA 934758 A CA934758 A CA 934758A
- Authority
- CA
- Canada
- Prior art keywords
- dicarboxylates
- unsymmetrical
- dihydropyridine
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19712117573 DE2117573C3 (de) | 1971-04-10 | 1971-04-10 | Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA934758A true CA934758A (en) | 1973-10-02 |
Family
ID=5804435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA139293A Expired CA934758A (en) | 1971-04-10 | 1972-04-10 | Process for the preparation of unsymmetrical 1,4-dihydropyridine 3,5-dicarboxylates |
Country Status (19)
| Country | Link |
|---|---|
| JP (1) | JPS5529990B1 (fi) |
| AT (1) | AT315178B (fi) |
| BG (1) | BG20105A3 (fi) |
| CA (1) | CA934758A (fi) |
| CH (1) | CH571492A5 (fi) |
| CS (1) | CS178407B2 (fi) |
| DD (1) | DD104520A5 (fi) |
| DE (1) | DE2117573C3 (fi) |
| DK (1) | DK134600C (fi) |
| ES (1) | ES401616A1 (fi) |
| FI (1) | FI55188C (fi) |
| HU (1) | HU163996B (fi) |
| LU (1) | LU65130A1 (fi) |
| NL (1) | NL170535C (fi) |
| NO (1) | NO133712C (fi) |
| PL (1) | PL83824B1 (fi) |
| RO (1) | RO61069A (fi) |
| SE (1) | SE371441B (fi) |
| SU (1) | SU421193A3 (fi) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4622332A (en) * | 1982-03-10 | 1986-11-11 | Bayer Aktiengesellschaft | Asymmetric diesters of Hantzsch dihydropyridines with hypotensive activity |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2320750A1 (fr) * | 1975-08-12 | 1977-03-11 | Hexachimie | Dihydro-1,4 pyridines et leur application therapeutique |
| DE2650013C3 (de) * | 1976-10-30 | 1981-04-02 | Bayer Ag, 5090 Leverkusen | 1.4-Dihydro-2.6-dimethyl-4-(3-nitrophenyl)-3.5-pyridindicarbonsäureisopropyl-(2-propoxy-äthyl)-ester, Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel |
| DE2815578C2 (de) * | 1978-04-11 | 1986-01-16 | Bayer Ag, 5090 Leverkusen | Neue pharmazeutische Verwendung von Nimodipin |
| SE429652B (sv) * | 1978-06-30 | 1983-09-19 | Haessle Ab | 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester |
| DE2841667A1 (de) * | 1978-09-25 | 1980-04-10 | Bayer Ag | Fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| JPS58159490A (ja) * | 1982-02-23 | 1983-09-21 | Nikken Kagaku Kk | １，４−ジヒドロピリジン化合物 |
| JPS58185562A (ja) * | 1982-04-22 | 1983-10-29 | Taisho Pharmaceut Co Ltd | １，４−ジヒドロピリジン誘導体 |
| DE3222367A1 (de) * | 1982-06-15 | 1983-12-15 | Bayer Ag, 5090 Leverkusen | Verwendung von 1,4-dihydropyridinen in antiarteriosklerotika und deren herstellung |
| US4656181A (en) * | 1982-11-24 | 1987-04-07 | Cermol S.A. | Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same |
| US4529733A (en) * | 1983-04-06 | 1985-07-16 | Merrell Dow Pharmaceuticals Inc. | Antihypertensive 3-furoyl-1,4-dihydropyridines |
| US4607041A (en) * | 1983-04-27 | 1986-08-19 | Fisons Plc | Antihypertensive 2-phenyl Hantzsch dihydropyridines |
| IE57810B1 (en) * | 1984-03-27 | 1993-04-21 | Delagrange Lab | 1,4-dihydropyridine derivatives,their preparation and their use |
| EP0311053A3 (en) * | 1987-10-06 | 1991-05-08 | Banyu Pharmaceutical Co., Ltd. | Ameliorant of cerebral circulation and optical isomer of nb-818, processes for its production and its use |
| DE3741540A1 (de) * | 1987-12-08 | 1989-06-22 | Bayer Ag | Verfahren zur herstellung von unsymmetrischen dihydropyridinen |
| ES2193148T3 (es) * | 1993-12-10 | 2003-11-01 | Bayer Ag | 1,4-dihidropiridinas sustituidas con fenilo con actividad cerebral. |
| US5977369A (en) * | 1995-12-28 | 1999-11-02 | Napp Technologies, Inc. | Process to prepare dihydropyridine and derivatives thereof |
| IT1283793B1 (it) * | 1996-08-23 | 1998-04-30 | Lusochimica Spa | Processo per la preparazione di diidropiridine |
| WO2000005209A1 (en) * | 1998-07-23 | 2000-02-03 | Lin, Tong-Ho | GUAIACOXYPROPANOLAMINES WITH α/β-ADRENERGIC BLOCKING ACTIVITY |
-
1971
- 1971-04-10 DE DE19712117573 patent/DE2117573C3/de not_active Expired
-
1972
- 1972-03-09 CH CH346072A patent/CH571492A5/xx not_active IP Right Cessation
- 1972-04-05 SU SU1768161A patent/SU421193A3/ru active
- 1972-04-06 BG BG020166A patent/BG20105A3/xx unknown
- 1972-04-06 FI FI94872A patent/FI55188C/fi active
- 1972-04-07 NL NL7204695A patent/NL170535C/xx not_active IP Right Cessation
- 1972-04-07 DD DD16215572A patent/DD104520A5/xx unknown
- 1972-04-07 LU LU65130D patent/LU65130A1/xx unknown
- 1972-04-07 NO NO119272A patent/NO133712C/no unknown
- 1972-04-07 DK DK172472A patent/DK134600C/da not_active IP Right Cessation
- 1972-04-07 JP JP3450872A patent/JPS5529990B1/ja active Pending
- 1972-04-07 AT AT301872A patent/AT315178B/de active
- 1972-04-08 PL PL15462572A patent/PL83824B1/pl unknown
- 1972-04-08 ES ES401616A patent/ES401616A1/es not_active Expired
- 1972-04-10 HU HUBA002727 patent/HU163996B/hu unknown
- 1972-04-10 CA CA139293A patent/CA934758A/en not_active Expired
- 1972-04-10 CS CS237972A patent/CS178407B2/cs unknown
- 1972-04-10 RO RO7048872A patent/RO61069A/ro unknown
- 1972-04-10 SE SE460872A patent/SE371441B/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4622332A (en) * | 1982-03-10 | 1986-11-11 | Bayer Aktiengesellschaft | Asymmetric diesters of Hantzsch dihydropyridines with hypotensive activity |
Also Published As
| Publication number | Publication date |
|---|---|
| NO133712B (fi) | 1976-03-08 |
| JPS5529990B1 (fi) | 1980-08-07 |
| PL83824B1 (fi) | 1976-02-28 |
| NO133712C (fi) | 1976-06-16 |
| SE371441B (fi) | 1974-11-18 |
| CS178407B2 (fi) | 1977-09-15 |
| HU163996B (fi) | 1973-12-28 |
| LU65130A1 (fi) | 1972-07-12 |
| NL170535C (nl) | 1982-11-16 |
| DK134600B (da) | 1976-12-06 |
| FI55188C (fi) | 1979-06-11 |
| DK134600C (da) | 1977-05-16 |
| BG20105A3 (bg) | 1975-10-30 |
| DE2117573B2 (de) | 1977-12-01 |
| DD104520A5 (fi) | 1974-03-12 |
| FI55188B (fi) | 1979-02-28 |
| CH571492A5 (fi) | 1976-01-15 |
| NL170535B (nl) | 1982-06-16 |
| DE2117573C3 (de) | 1978-07-27 |
| DE2117573A1 (de) | 1972-10-19 |
| RO61069A (fi) | 1976-11-15 |
| AT315178B (de) | 1974-05-10 |
| NL7204695A (fi) | 1972-10-12 |
| ES401616A1 (es) | 1975-02-16 |
| SU421193A3 (ru) | 1974-03-25 |
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