CA933381A - Method for detecting trace quantities of an organic drug material in a living animal - Google Patents

Method for detecting trace quantities of an organic drug material in a living animal

Info

Publication number
CA933381A
CA933381A CA108697A CA108697A CA933381A CA 933381 A CA933381 A CA 933381A CA 108697 A CA108697 A CA 108697A CA 108697 A CA108697 A CA 108697A CA 933381 A CA933381 A CA 933381A
Authority
CA
Canada
Prior art keywords
living animal
drug material
trace quantities
detecting trace
organic drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA108697A
Other languages
English (en)
Other versions
CA108697S (en
Inventor
P. Littlejohn Duane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Varian Medical Systems Inc
Original Assignee
Varian Associates Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Varian Associates Inc filed Critical Varian Associates Inc
Application granted granted Critical
Publication of CA933381A publication Critical patent/CA933381A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring blood gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1477—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means non-invasive
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/90—Breath testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/901—Drugs of abuse, e.g. narcotics, amphetamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/20—Oxygen containing
    • Y10T436/203332—Hydroxyl containing
    • Y10T436/204165—Ethanol
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Optics & Photonics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Food Science & Technology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
CA108697A 1970-03-26 1971-03-25 Method for detecting trace quantities of an organic drug material in a living animal Expired CA933381A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2294070A 1970-03-26 1970-03-26

Publications (1)

Publication Number Publication Date
CA933381A true CA933381A (en) 1973-09-11

Family

ID=21812218

Family Applications (1)

Application Number Title Priority Date Filing Date
CA108697A Expired CA933381A (en) 1970-03-26 1971-03-25 Method for detecting trace quantities of an organic drug material in a living animal

Country Status (6)

Country Link
US (1) US3649199A (de)
CA (1) CA933381A (de)
DE (1) DE2113729C3 (de)
FR (1) FR2085144A5 (de)
GB (1) GB1343156A (de)
SE (1) SE380096B (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
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US3724175A (en) * 1971-08-05 1973-04-03 Gen Electric Composite membrane useful in noninvasive sensor for gases and vapors
US3726270A (en) * 1971-09-20 1973-04-10 Syst Res Labor Inc Pulmonary information transmission system
US3927670A (en) * 1973-01-05 1975-12-23 Stephen Z Turney Automatic respiratory gas monitoring system
US3948604A (en) * 1974-01-02 1976-04-06 Borg-Warner Corporation Alcoholic breath simulation system
US3983864A (en) * 1974-08-01 1976-10-05 Airco, Inc. Method and apparatus for in vivo blood gas analysis
US4119402A (en) * 1976-09-10 1978-10-10 Thermo Electron Corporation Method to measure in vivo N-nitroso compounds
US4187856A (en) * 1978-04-03 1980-02-12 The Perkin-Elmer Corporation High-speed transmission of blood stream gases
US4167667A (en) * 1978-06-12 1979-09-11 The Perkin-Elmer Corporation Respiratory gas moisture separator system for mass spectrometer monitoring systems
US4439679A (en) * 1981-04-10 1984-03-27 The Regents Of The University Of California Transcutaneous gas tension measurement using a dual sampling chamber and gas analysis system
US4791292A (en) * 1986-04-24 1988-12-13 The Dow Chemical Company Capillary membrane interface for a mass spectrometer
US4765339A (en) * 1986-06-04 1988-08-23 Solutech, Inc. Closed loop dialysis system
US4777953A (en) * 1987-02-25 1988-10-18 Ash Medical Systems, Inc. Capillary filtration and collection method for long-term monitoring of blood constituents
CA1305873C (en) * 1987-05-26 1992-08-04 Howel Gwynne Giles Method and means for detecting alcohol levels in humans
KR900701352A (ko) * 1988-05-20 1990-12-01 원본미기재 물 오염을 방지하기 위한 환자 인터페이싱 시스템 및 방법
US5233996A (en) * 1988-05-20 1993-08-10 Boc Health Care, Inc. Patient interfacing system and method to prevent water contamination
US5078135A (en) * 1989-05-31 1992-01-07 Board Of Regents, The University Of Texas System Apparatus for in vivo analysis of biological compounds in blood or tissue by microdialysis and mass spectrometry
DE3932784C3 (de) * 1989-09-30 2002-08-01 Nmi Univ Tuebingen Verfahren zur Gewinnung nichtflüchtiger Substanzen als analytisches Probenmaterial aus der menschlichen Atemluft
US5209919A (en) * 1990-07-13 1993-05-11 Regents Of The University Of California Method of measurement in biological systems
US5220919A (en) * 1991-08-23 1993-06-22 Safety Technology Partners, Ltd. Blood alcohol monitor
US5304796A (en) * 1992-03-25 1994-04-19 The Boc Group, Inc. Atmospheric pressure ionization mass spectroscopy method including a silica gel drying step
NL9200731A (nl) * 1992-04-22 1993-11-16 Jacob Korf Werkwijze en inrichting voor het niet-invasief bewaken van de concentratie van stoffen in bloed.
US5261793A (en) * 1992-08-05 1993-11-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Miniature mechanical vacuum pump
FR2695208A1 (fr) * 1992-08-25 1994-03-04 Inocosm Laboratoires Procédé de prélèvement et de concentration de produits volatils, issus de la peroxydation des acides gras poly-insaturés, ainsi que dispositifs permettant la mise en Óoeuvre de ce procédé.
CA2119888C (en) * 1992-09-25 2001-09-11 Mary F. Phillips Blood alcohol monitor
US5479815A (en) * 1994-02-24 1996-01-02 Kraft Foods, Inc. Method and apparatus for measuring volatiles released from food products
US5641458A (en) * 1995-06-15 1997-06-24 Shockley, Jr.; H. David Flow through cell assembly
WO1998011434A1 (en) * 1996-09-13 1998-03-19 The Trustees Of The University Of Pennsylvania Membrane countercurrent exchanger and membrane inlet mass spectrometry for the analysis of gas partial pressures in liquids
US5962335A (en) 1997-01-03 1999-10-05 Oridion Medical Ltd. Breath test for detection of drug metabolism
US6271920B1 (en) 1997-12-19 2001-08-07 Chromatics Color Sciences International, Inc. Methods and apparatus for color calibration and verification
JP4773019B2 (ja) * 1999-11-08 2011-09-14 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド 薬物の服薬遵守を監視するためのマーカー検出の方法および器具
US20020177232A1 (en) * 2001-05-23 2002-11-28 Melker Richard J. Method and apparatus for detecting illicit substances
US20050037374A1 (en) * 1999-11-08 2005-02-17 Melker Richard J. Combined nanotechnology and sensor technologies for simultaneous diagnosis and treatment
US6981947B2 (en) 2002-01-22 2006-01-03 University Of Florida Research Foundation, Inc. Method and apparatus for monitoring respiratory gases during anesthesia
US7104963B2 (en) * 2002-01-22 2006-09-12 University Of Florida Research Foundation, Inc. Method and apparatus for monitoring intravenous (IV) drug concentration using exhaled breath
JP3850662B2 (ja) * 2000-12-27 2006-11-29 独立行政法人科学技術振興機構 皮膚透過ガス収集装置
US7004909B1 (en) * 2001-03-19 2006-02-28 Pranalytica, Inc. Diagnostic method for high sensitivity detection of component concentrations in human gas emissions
FR2822952B1 (fr) * 2001-03-27 2006-09-22 Seres Detecteur d'une signature volatile et procedes associes
US7052854B2 (en) * 2001-05-23 2006-05-30 University Of Florida Research Foundation, Inc. Application of nanotechnology and sensor technologies for ex-vivo diagnostics
WO2002095398A1 (en) * 2001-05-24 2002-11-28 University Of Florida Method and apparatus for detecting environmental smoke exposure
US20070167853A1 (en) * 2002-01-22 2007-07-19 Melker Richard J System and method for monitoring health using exhaled breath
US20060160134A1 (en) * 2002-10-21 2006-07-20 Melker Richard J Novel application of biosensors for diagnosis and treatment of disease
US20050191757A1 (en) * 2004-01-20 2005-09-01 Melker Richard J. Method and apparatus for detecting humans and human remains
US20060062734A1 (en) * 2004-09-20 2006-03-23 Melker Richard J Methods and systems for preventing diversion of prescription drugs
US20060257883A1 (en) * 2005-05-10 2006-11-16 Bjoraker David G Detection and measurement of hematological parameters characterizing cellular blood components
CA2645041A1 (en) * 2006-03-07 2007-09-13 University Of Florida Research Foundation, Inc. Drug adherence monitoring system
US7914460B2 (en) * 2006-08-15 2011-03-29 University Of Florida Research Foundation, Inc. Condensate glucose analyzer
GB0702592D0 (en) 2007-02-10 2007-03-21 Unilever Plc Sampler and method of sampling
DE102009055320B4 (de) 2009-12-24 2011-09-01 Humedics Gmbh Messvorrichtung und Verfahren zur Untersuchung eines Probegases mittels Infrarot-Absorptionsspektroskopie
WO2011117900A1 (en) * 2010-03-22 2011-09-29 Mchele Pitaro Portable device for detecting drugs in breath
US8931696B2 (en) 2011-08-17 2015-01-13 Darden Gwaltney Hood Counterfeit detection system and method
US8439258B1 (en) 2011-08-17 2013-05-14 Darden Gwaltney Hood Counterfeit detection system and method
WO2016112248A1 (en) * 2015-01-09 2016-07-14 Exhalix Llc Transdermal sampling strip and method for analyzing transdermally emitted gases
US20160370337A1 (en) * 2015-06-16 2016-12-22 Lunatech, Llc Analysis System For Biological Compounds, And Method Of Operation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3455092A (en) * 1965-12-06 1969-07-15 Varian Associates Gas analyzer inlet system for gaseous state materials
US3398505A (en) * 1965-12-06 1968-08-27 Varian Associates Dual stage membrane gas separators with variable conductance means for varying their throughput

Also Published As

Publication number Publication date
FR2085144A5 (de) 1971-12-17
DE2113729A1 (de) 1971-10-14
DE2113729B2 (de) 1979-07-19
US3649199A (en) 1972-03-14
SE380096B (de) 1975-10-27
DE2113729C3 (de) 1980-04-03
GB1343156A (en) 1974-01-10

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