CA3281699A1 - Analyte sensors employing multiple enzymes and methods associated therewith - Google Patents

Analyte sensors employing multiple enzymes and methods associated therewith

Info

Publication number
CA3281699A1
CA3281699A1 CA3281699A CA3281699A CA3281699A1 CA 3281699 A1 CA3281699 A1 CA 3281699A1 CA 3281699 A CA3281699 A CA 3281699A CA 3281699 A CA3281699 A CA 3281699A CA 3281699 A1 CA3281699 A1 CA 3281699A1
Authority
CA
Canada
Prior art keywords
associated therewith
analyte sensors
employing multiple
methods associated
multiple enzymes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3281699A
Other languages
English (en)
Inventor
Stephen Oja
Tianmei Ouyang
Hyun Cho
Lam N. Tran
Benjamin J. Feldman
Original Assignee
Abbott Diabetes Care Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Diabetes Care Inc filed Critical Abbott Diabetes Care Inc
Publication of CA3281699A1 publication Critical patent/CA3281699A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6848—Needles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/9029—Oxidoreductases (1.) acting on -CH2- groups (1.17)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/904—Oxidoreductases (1.) acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/908—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Electrochemistry (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA3281699A 2019-01-28 2020-01-28 Analyte sensors employing multiple enzymes and methods associated therewith Pending CA3281699A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962797566P 2019-01-28 2019-01-28
US62/797,566 2019-01-28
CA3126240A CA3126240A1 (en) 2019-01-28 2020-01-28 Analyte sensors employing multiple enzymes and methods associated therewith

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA3126240A Division CA3126240A1 (en) 2019-01-28 2020-01-28 Analyte sensors employing multiple enzymes and methods associated therewith

Publications (1)

Publication Number Publication Date
CA3281699A1 true CA3281699A1 (en) 2026-03-02

Family

ID=69740596

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3281699A Pending CA3281699A1 (en) 2019-01-28 2020-01-28 Analyte sensors employing multiple enzymes and methods associated therewith
CA3126240A Pending CA3126240A1 (en) 2019-01-28 2020-01-28 Analyte sensors employing multiple enzymes and methods associated therewith

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3126240A Pending CA3126240A1 (en) 2019-01-28 2020-01-28 Analyte sensors employing multiple enzymes and methods associated therewith

Country Status (13)

Country Link
US (8) US12048539B2 (https=)
EP (5) EP4663121A1 (https=)
JP (3) JP7410158B2 (https=)
CN (2) CN113382680B (https=)
AU (3) AU2020214230B2 (https=)
CA (2) CA3281699A1 (https=)
DK (1) DK3917394T3 (https=)
ES (1) ES2992515T3 (https=)
FI (1) FI3917394T3 (https=)
LT (1) LT3917394T (https=)
MX (2) MX2021009070A (https=)
MY (1) MY198077A (https=)
WO (1) WO2020159927A1 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2974312T3 (es) 2016-03-04 2024-06-26 Abbott Diabetes Care Inc Enzimas sensibles dependientes de NAD(P), electrodos y sensores y procedimientos para la fabricación y utilización de los mismos
ES2831076T3 (es) * 2017-11-08 2021-06-07 Hoffmann La Roche Sensor para detectar un analito en un líquido corporal y procedimiento de fabricación del mismo
EP4663121A1 (en) 2019-01-28 2025-12-17 Abbott Diabetes Care Inc. Analyte sensors employing multiple enzymes
DK3917396T3 (da) 2019-01-28 2024-12-02 Abbott Diabetes Care Inc Analytsensorer, der er forsynet med dualdetektering af glukose og ketoner
EP4552565A1 (en) 2019-01-28 2025-05-14 Abbott Diabetes Care, Inc. Analyte sensors and sensing methods for dual detection of glucose and ethanol
WO2021138473A1 (en) 2020-01-03 2021-07-08 Abbott Diabetes Care Inc. Sensor array systems and methods for detecting multiple analytes
CN116829068A (zh) * 2020-12-10 2023-09-29 美国雅培糖尿病护理公司 用于传感酮的分析物传感器和使用其的方法
JP7657932B2 (ja) * 2020-12-10 2025-04-07 アボット ダイアベティス ケア インコーポレイテッド ケトン類を検知するための被検物質センサ及びそれを使用する方法
WO2022132963A1 (en) * 2020-12-15 2022-06-23 Abbott Diabetes Care Inc. Nad(p) depot for nad(p)-dependent enzyme-based sensors
CA3202481A1 (en) * 2020-12-18 2022-06-23 Benjamin J. Feldman Systems and methods for analyte detection
CA3201036A1 (en) * 2020-12-18 2022-06-23 Benjamin J. Feldman Systems and methods for analyte detection
EP4267752A1 (en) * 2020-12-23 2023-11-01 Abbott Diabetes Care, Inc. Analyte sensors for sensing glutamate and methods of using the same
EP4271825A1 (en) 2020-12-30 2023-11-08 Abbott Diabetes Care, Inc. Analyte sensors for detecting asparagine and aspartate and methods of use thereof
AU2022205038B2 (en) * 2020-12-31 2025-12-04 Abbott Diabetes Care Inc. Analyte sensors and methods of use thereof
JP7842108B2 (ja) 2021-01-22 2026-04-07 アナログ・ディヴァイシス・インターナショナル・アンリミテッド・カンパニー 検知アセンブリ
AU2022345781A1 (en) 2021-09-15 2024-03-07 Lingo Sensing Technology Unlimited Company Systems, devices, and methods for applications for communication with ketone sensors
EP4433099A4 (en) * 2021-11-19 2025-11-05 Abbott Diabetes Care Inc ANALYTE SENSORS FOR DETECTING GLUTAMATE AND METHODS OF USING THESE
US12527500B2 (en) 2021-12-02 2026-01-20 Medtronic Minimed, Inc. Ketone limiting membrane and dual layer membrane approach for ketone sensing
JP2025533414A (ja) 2022-09-15 2025-10-07 アボット ダイアベティス ケア インコーポレイテッド デュアル被検物質センサのためのシステム、装置および方法
WO2025064882A2 (en) 2023-09-22 2025-03-27 Abbott Diabetes Care Inc. Decision support for glucose-ketone sensor
US20250299818A1 (en) 2024-03-25 2025-09-25 Abbott Diabetes Care Inc. Deployment and use of a continuous analyte monitoring system for improved home monitoring and readmission optimization
WO2026008473A1 (en) * 2024-07-01 2026-01-08 Roche Diabetes Care Gmbh An in vivo analyte sensor and a method of manufacturing an in vivo analyte sensor

Family Cites Families (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4321123A (en) 1978-04-21 1982-03-23 Matsushita Electric Industrial Co., Ltd. Coenzyme immobilized electrode
GB2067764B (en) 1980-01-09 1984-01-25 Nat Res Dev Transcutaneous gas sensor
US5682884A (en) 1983-05-05 1997-11-04 Medisense, Inc. Strip electrode with screen printing
US4680268A (en) 1985-09-18 1987-07-14 Children's Hospital Medical Center Implantable gas-containing biosensor and method for measuring an analyte such as glucose
US5262035A (en) 1989-08-02 1993-11-16 E. Heller And Company Enzyme electrodes
US5264105A (en) 1989-08-02 1993-11-23 Gregg Brian A Enzyme electrodes
US5593852A (en) 1993-12-02 1997-01-14 Heller; Adam Subcutaneous glucose electrode
CA2050057A1 (en) 1991-03-04 1992-09-05 Adam Heller Interferant eliminating biosensors
US5322063A (en) 1991-10-04 1994-06-21 Eli Lilly And Company Hydrophilic polyurethane membranes for electrochemical glucose sensors
US5965106A (en) 1992-03-04 1999-10-12 Perimmune Holdings, Inc. In vivo binding pair pretargeting
DE4442253A1 (de) 1994-11-28 1996-05-30 Bayer Corp N D Ges D Staates I Elektrochemischer Enzymbiosensor
US5792621A (en) 1995-06-28 1998-08-11 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Fiber-optic chemiluminescent biosensors for monitoring aqueous alcohols and other water quality parameters
US5696314A (en) * 1996-07-12 1997-12-09 Chiron Diagnostics Corporation Multilayer enzyme electrode membranes and methods of making same
US6071391A (en) 1997-09-12 2000-06-06 Nok Corporation Enzyme electrode structure
US6736957B1 (en) 1997-10-16 2004-05-18 Abbott Laboratories Biosensor electrode mediators for regeneration of cofactors and process for using
US6579690B1 (en) 1997-12-05 2003-06-17 Therasense, Inc. Blood analyte monitoring through subcutaneous measurement
US6030827A (en) 1998-01-23 2000-02-29 I-Stat Corporation Microfabricated aperture-based sensor
US6134461A (en) 1998-03-04 2000-10-17 E. Heller & Company Electrochemical analyte
US6241863B1 (en) 1998-04-27 2001-06-05 Harold G. Monbouquette Amperometric biosensors based on redox enzymes
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US5965105A (en) 1998-06-12 1999-10-12 Council Of Scientific And Industrial Research Process for the synthesis of flyash based Zeolite-A
US6294281B1 (en) 1998-06-17 2001-09-25 Therasense, Inc. Biological fuel cell and method
US5902731A (en) 1998-09-28 1999-05-11 Lifescan, Inc. Diagnostics based on tetrazolium compounds
EP1135678A2 (en) 1998-11-30 2001-09-26 Abbott Laboratories Analyte test instrument having improved calibration and communications processes
EP2322645A1 (en) 1999-06-18 2011-05-18 Abbott Diabetes Care Inc. Mass transport limited in vivo analyte sensor
US6514460B1 (en) 1999-07-28 2003-02-04 Abbott Laboratories Luminous glucose monitoring device
US8444834B2 (en) 1999-11-15 2013-05-21 Abbott Diabetes Care Inc. Redox polymers for use in analyte monitoring
CA2391423A1 (en) 1999-11-15 2001-05-25 Therasense, Inc. Polymeric transition metal complexes and uses thereof
US8268143B2 (en) 1999-11-15 2012-09-18 Abbott Diabetes Care Inc. Oxygen-effect free analyte sensor
US6541216B1 (en) 1999-12-22 2003-04-01 Roche Diagnostics Corporation Amperometric biosensor test strip
AU2001263022A1 (en) 2000-05-12 2001-11-26 Therasense, Inc. Electrodes with multilayer membranes and methods of using and making the electrodes
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
US6676816B2 (en) 2001-05-11 2004-01-13 Therasense, Inc. Transition metal complexes with (pyridyl)imidazole ligands and sensors using said complexes
US6932894B2 (en) 2001-05-15 2005-08-23 Therasense, Inc. Biosensor membranes composed of polymers containing heterocyclic nitrogens
US6915147B2 (en) 2001-09-07 2005-07-05 Medtronic Minimed, Inc. Sensing apparatus and process
US6984307B2 (en) 2001-10-05 2006-01-10 Stephen Eliot Zweig Dual glucose-hydroxybutyrate analytical sensors
GB0130684D0 (en) 2001-12-21 2002-02-06 Oxford Biosensors Ltd Micro-band electrode
US8364229B2 (en) 2003-07-25 2013-01-29 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US6946299B2 (en) 2002-04-25 2005-09-20 Home Diagnostics, Inc. Systems and methods for blood glucose sensing
US20040061232A1 (en) 2002-09-27 2004-04-01 Medtronic Minimed, Inc. Multilayer substrate
US7501053B2 (en) 2002-10-23 2009-03-10 Abbott Laboratories Biosensor having improved hematocrit and oxygen biases
AU2003303597A1 (en) 2002-12-31 2004-07-29 Therasense, Inc. Continuous glucose monitoring system and methods of use
JP4839569B2 (ja) 2003-06-05 2011-12-21 ソニー株式会社 酵素固定化電極およびその製造方法ならびに電極反応利用装置およびその製造方法
US7761130B2 (en) 2003-07-25 2010-07-20 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7460898B2 (en) 2003-12-05 2008-12-02 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US9763609B2 (en) 2003-07-25 2017-09-19 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US7563588B2 (en) 2003-10-29 2009-07-21 Agency For Science, Technology And Research Electrically non-conductive, nanoparticulate membrane
US7299082B2 (en) 2003-10-31 2007-11-20 Abbott Diabetes Care, Inc. Method of calibrating an analyte-measurement device, and associated methods, devices and systems
DE602004028649D1 (de) * 2003-11-13 2010-09-23 Medtronic Minimed Inc Langzeit-analytensensor-anordnung
US8414489B2 (en) * 2003-11-13 2013-04-09 Medtronic Minimed, Inc. Fabrication of multi-sensor arrays
WO2005057168A2 (en) 2003-12-05 2005-06-23 Dexcom, Inc. Calibration techniques for a continuous analyte sensor
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8948836B2 (en) 2003-12-26 2015-02-03 Medtronic Minimed, Inc. Implantable apparatus for sensing multiple parameters
US8165651B2 (en) 2004-02-09 2012-04-24 Abbott Diabetes Care Inc. Analyte sensor, and associated system and method employing a catalytic agent
WO2006026748A1 (en) 2004-08-31 2006-03-09 Lifescan Scotland Limited Method of manufacturing an auto-calibrating sensor
US8211038B2 (en) 2004-09-17 2012-07-03 Abbott Diabetes Care Inc. Multiple-biosensor article
US7545272B2 (en) 2005-02-08 2009-06-09 Therasense, Inc. RF tag on test strips, test strip vials and boxes
US8060174B2 (en) 2005-04-15 2011-11-15 Dexcom, Inc. Analyte sensing biointerface
US20070095661A1 (en) 2005-10-31 2007-05-03 Yi Wang Method of making, and, analyte sensor
JP2007163268A (ja) 2005-12-13 2007-06-28 Canon Inc 酵素電極
JP4802842B2 (ja) 2006-04-24 2011-10-26 株式会社デンソー 健康管理支援装置及び健康管理システム
US9700252B2 (en) 2006-06-19 2017-07-11 Roche Diabetes Care, Inc. Amperometric sensor and method for its manufacturing
US7822557B2 (en) 2006-10-31 2010-10-26 Abbott Diabetes Care Inc. Analyte sensors and methods
US8808515B2 (en) 2007-01-31 2014-08-19 Abbott Diabetes Care Inc. Heterocyclic nitrogen containing polymers coated analyte monitoring device and methods of use
EP2171031B1 (en) 2007-06-21 2018-12-05 Abbott Diabetes Care Inc. Health management devices and methods
CA2700507C (en) 2007-09-24 2018-05-29 Bayer Healthcare Llc Multi-region and potential test sensors, methods, and systems
US20100268043A1 (en) 2007-11-07 2010-10-21 Ofer Yodfat Device and Method for Preventing Diabetic Complications
WO2009100082A1 (en) 2008-02-04 2009-08-13 Bayer Healthcare Llc Semiconductor based analyte sensors and methods
CA2715624A1 (en) 2008-02-20 2009-08-27 Dexcom, Inc. Continuous medicament sensor system for in vivo use
JP2009245930A (ja) 2008-03-12 2009-10-22 Sony Corp 燃料電池およびその製造方法ならびに酵素固定化電極およびその製造方法ならびに電子機器
US8396528B2 (en) * 2008-03-25 2013-03-12 Dexcom, Inc. Analyte sensor
JP2009272179A (ja) 2008-05-08 2009-11-19 Sony Corp 新規な酵素電極及び該酵素電極を用いた燃料電池
US8620398B2 (en) 2008-06-02 2013-12-31 Abbott Diabetes Care Inc. Reference electrodes having an extended lifetime for use in long term amperometric sensors
US8636884B2 (en) 2008-09-15 2014-01-28 Abbott Diabetes Care Inc. Cationic polymer based wired enzyme formulations for use in analyte sensors
KR20110081170A (ko) 2008-10-06 2011-07-13 소니 주식회사 연료 전지 및 효소 전극
US8608922B2 (en) * 2008-11-07 2013-12-17 The University Of Connecticut Biosensor for continuous monitoring of metabolites and proteins and methods of manufacture thereof
US9402544B2 (en) 2009-02-03 2016-08-02 Abbott Diabetes Care Inc. Analyte sensor and apparatus for insertion of the sensor
WO2010099507A1 (en) 2009-02-26 2010-09-02 Abbott Diabetes Care Inc. Improved analyte sensors and methods of making and using the same
US20100213057A1 (en) * 2009-02-26 2010-08-26 Benjamin Feldman Self-Powered Analyte Sensor
US8298158B2 (en) 2009-06-30 2012-10-30 Abbott Diabetes Care Inc. Integrated devices having extruded electrode structures and methods of using same
US9351677B2 (en) 2009-07-02 2016-05-31 Dexcom, Inc. Analyte sensor with increased reference capacity
JP5795584B2 (ja) 2009-08-31 2015-10-14 アボット ダイアベティス ケア インコーポレイテッドＡｂｂｏｔｔ Ｄｉａｂｅｔｅｓ Ｃａｒｅ Ｉｎｃ． 医療用装置
WO2011030093A1 (en) 2009-09-04 2011-03-17 Lifescan Scotland Limited Glucose measurement method and system
EP4087195B2 (en) 2009-09-08 2026-01-28 Abbott Diabetes Care, Inc. Methods and articles of manufacture for hosting a safety critical application on an uncontrolled data processing device
US20120181189A1 (en) 2009-09-24 2012-07-19 Fresenius Medical Care Holdings, Inc. Amperometric Creatinine Biosensor With Immobilized Enzyme-Polymer Composition And Systems Using Same, And Methods
US8545693B2 (en) 2009-09-29 2013-10-01 Lifescan Scotland Limited Analyte measurment method and system
US20120283537A1 (en) 2009-10-30 2012-11-08 Petisce James R Analyte sensor layers and methods related thereto
US20110124993A1 (en) 2009-11-24 2011-05-26 Abbott Diabetes Care Inc. Analyte Sensors Comprising Self-Polymerizing Hydrogels
US9042954B2 (en) 2009-11-24 2015-05-26 Abbott Diabetes Care Inc. Analyte sensors comprising hydrogel membranes
US8354013B2 (en) 2009-11-24 2013-01-15 Abbott Diabetes Care Inc. Analyte sensors comprising high-boiling point solvents
US8497359B2 (en) 2010-02-26 2013-07-30 Ppg Industries Ohio, Inc. Cationic electrodepositable coating composition comprising lignin
AU2011239548A1 (en) 2010-04-16 2012-01-19 Abbott Diabetes Care Inc. Analyte monitoring device and methods
US20110256024A1 (en) 2010-04-16 2011-10-20 Abbott Diabetes Care Inc. Modular Analyte Monitoring Device
JP5423580B2 (ja) 2010-05-17 2014-02-19 トヨタ自動車株式会社 酵素電極およびそれを備えるバイオ燃料電池
US9402574B2 (en) * 2010-06-25 2016-08-02 The University Of Connecticut Sensors for analyte detection and methods of manufacture thereof
EP2598021B1 (en) 2010-07-28 2015-08-19 Abbott Diabetes Care, Inc. Analyte sensors having temperature independent membranes
US20130211219A1 (en) 2010-08-24 2013-08-15 Micro CHIPS ,Inc. Implantable Biosensor Device and Methods of Use Thereof
WO2012068393A1 (en) 2010-11-18 2012-05-24 Abbott Diabetes Care Inc. Adaptor for on-body analyte monitoring system
US9468402B2 (en) 2010-12-01 2016-10-18 Pinnacle Technology, Inc. Tissue implantable microbiosensor
US20120138484A1 (en) 2010-12-03 2012-06-07 Abbott Diabetes Care Inc. Analyte Sensors Comprising Thickeners, Enzyme Stabilizers and Osmium Boronates
EP2649191B1 (en) 2010-12-09 2021-06-16 Abbott Diabetes Care, Inc. Analyte sensors with a sensing surface having small sensing spots
US8608921B2 (en) 2011-01-20 2013-12-17 Medtronic Minimed, Inc. Layered enzyme compositions for use with analyte sensors
CN103619255B (zh) 2011-02-28 2016-11-02 雅培糖尿病护理公司 与分析物监测装置关联的装置、系统和方法以及结合了它们的装置
US9380965B2 (en) 2011-05-20 2016-07-05 Abbott Diabetes Care Inc. Analyte sensors having a membrane with low temperature sensitivity
CA3105324A1 (en) 2011-06-17 2012-12-20 Abbott Diabetes Care Inc. Connectors for making connections between analyte sensors and other devices
CA2840640C (en) 2011-11-07 2020-03-24 Abbott Diabetes Care Inc. Analyte monitoring device and methods
US20140054171A1 (en) 2012-02-21 2014-02-27 Abbott Diabetes Care Inc. Analyte Sensor Utilizing Oxygen as Oxidant
US9535027B2 (en) 2012-07-25 2017-01-03 Abbott Diabetes Care Inc. Analyte sensors and methods of using same
US9743871B2 (en) 2012-09-24 2017-08-29 Dexcom, Inc. Multiple electrode system for a continuous analyte sensor, and related methods
US8920628B2 (en) 2012-11-02 2014-12-30 Roche Diagnostics Operations, Inc. Systems and methods for multiple analyte analysis
US8921061B2 (en) 2012-11-02 2014-12-30 Roche Diagnostics Operations, Inc. Reagent materials and associated test elements
US9344777B2 (en) * 2012-12-20 2016-05-17 Abbott Diabetes Care Inc. Wireless communication authentication for medical monitoring device
JP2014160024A (ja) 2013-02-20 2014-09-04 Jnc Corp 酵素修飾電極、該酵素修飾電極の製造方法、およびこれを用いた電気化学反応装置、並びにそれを用いた化学物質の製造方法
US9562874B2 (en) 2013-03-15 2017-02-07 Abbott Point Of Care Inc. Biosensor with improved interference characteristics
WO2014150876A2 (en) 2013-03-15 2014-09-25 Abbott Point Of Care Inc Biosensor structures for improved point of care testing and methods of manufacture thereof
EP3087771B1 (en) 2013-12-27 2020-06-17 Abbott Diabetes Care, Inc. Systems, devices, and methods for authentication in an analyte monitoring environment
EP2927319A1 (en) 2014-03-31 2015-10-07 Roche Diagnostics GmbH High load enzyme immobilization by crosslinking
WO2015195352A1 (en) 2014-06-20 2015-12-23 Abbott Diabetes Care Inc. Test strip, meter, and method for assaying enzyme activity
EP3179915A4 (en) 2014-08-15 2018-03-21 Abbott Diabetes Care Inc. Temperature insensitive in vivo analyte devices, methods and systems
ES2756714T3 (es) 2014-08-25 2020-04-27 Hoffmann La Roche Tira reactiva de dos electrodos que compensan la interferencia
US20170238851A1 (en) * 2014-08-26 2017-08-24 Echo Therapeutics, Inc. Differential Biosensor System
GB201507508D0 (en) 2015-04-30 2015-06-17 Inside Biometrics Ltd Electrochemical Test Device
JP6584821B2 (ja) 2015-04-30 2019-10-02 株式会社東芝 測定用セル、検出装置および分析装置
GB201507506D0 (en) 2015-04-30 2015-06-17 Inside Biometrics Ltd Electrochemical test device
US20160328990A1 (en) * 2015-05-07 2016-11-10 Dexcom, Inc. System and method for educating users, including responding to patterns
US10780222B2 (en) 2015-06-03 2020-09-22 Pacific Diabetes Technologies Inc Measurement of glucose in an insulin delivery catheter by minimizing the adverse effects of insulin preservatives
WO2016196993A2 (en) 2015-06-04 2016-12-08 Omni Biomedical, Inc. Multi-mediator reagent formulations for use in electrochemical detection
WO2016205378A1 (en) 2015-06-15 2016-12-22 Abbott Diabetes Care Inc. Stabilized lactate responsive enzymes, electrodes and sensors, and methods for making and using the same
US10238346B2 (en) 2015-09-25 2019-03-26 Sanmina Corporation System and method for a biosensor integrated in a vehicle
CN108350439A (zh) 2015-12-21 2018-07-31 豪夫迈·罗氏有限公司 来自粪产碱菌的突变体3-羟基丁酸脱氢酶及其相关方法和用途
EP3414325B1 (en) 2016-02-09 2020-01-29 Roche Diabetes Care GmbH Mutant 3-hydroxybutyrate dehydrogenase from rhodobacter sphaeroides as well as methods and uses involving the same
ES2974312T3 (es) 2016-03-04 2024-06-26 Abbott Diabetes Care Inc Enzimas sensibles dependientes de NAD(P), electrodos y sensores y procedimientos para la fabricación y utilización de los mismos
US10324058B2 (en) 2016-04-28 2019-06-18 Medtronic Minimed, Inc. In-situ chemistry stack for continuous glucose sensors
CA3035874C (en) 2016-10-05 2025-09-09 F. Hoffmann-La Roche Ag DETECTION REAGENTS AND ELECTRODE ARRANGEMENTS FOR MULTI-ANALYTICAL DIAGNOSTIC TEST ELEMENTS, AS WELL AS THEIR METHODS OF USE
EP3523640B1 (en) 2016-10-05 2023-01-18 Abbott Laboratories Devices for sample analysis
US20190271658A1 (en) 2016-10-24 2019-09-05 Phc Holdings Corporation Oxidizing agent for electron mediator
WO2019006413A1 (en) 2017-06-30 2019-01-03 Abbott Diabetes Care METHOD AND APPARATUS FOR ANALYTE DETECTION USING ELECTROCHEMICAL BIOSENSOR
EP4218568A1 (en) 2017-08-18 2023-08-02 Abbott Diabetes Care Inc. Analyte monitoring system storing a measured electrical characteristic of the in vivo analyte sensor of the system as individualized calibration information
WO2019089476A1 (en) 2017-10-30 2019-05-09 Abbott Diabetes Care Inc. Transcutaneous sensor with dual electrodes and methods of detecting and compensating for withdrawal of a transcutaneous sensor from a patient
US12076145B2 (en) 2018-04-19 2024-09-03 Abbott Diabetes Care Inc. Lactate sensors and associated methods
US11744492B2 (en) 2018-08-29 2023-09-05 Medtronic, Inc. Electrochemical sensor including multiple work electrodes and common reference electrode
CN113164106A (zh) 2018-12-07 2021-07-23 比奥林公司 测定生理液中循环酮体的上升水平
DK3917396T3 (da) 2019-01-28 2024-12-02 Abbott Diabetes Care Inc Analytsensorer, der er forsynet med dualdetektering af glukose og ketoner
EP4663121A1 (en) 2019-01-28 2025-12-17 Abbott Diabetes Care Inc. Analyte sensors employing multiple enzymes
EP4552565A1 (en) 2019-01-28 2025-05-14 Abbott Diabetes Care, Inc. Analyte sensors and sensing methods for dual detection of glucose and ethanol
EP4552566A1 (en) 2019-01-28 2025-05-14 Abbott Diabetes Care, Inc. Analyte sensors and sensing methods for detecting creatinine
WO2020194179A1 (en) 2019-03-24 2020-10-01 Baldwa Mehul Biosensor for detection of analytes in a fluid
WO2021138473A1 (en) 2020-01-03 2021-07-08 Abbott Diabetes Care Inc. Sensor array systems and methods for detecting multiple analytes

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