CA3230406A1 - Utilization of micro-rna for downregulation of cytotoxic transgene expression by modified vaccinia virus ankara (mva) - Google Patents

Utilization of micro-rna for downregulation of cytotoxic transgene expression by modified vaccinia virus ankara (mva) Download PDF

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Publication number
CA3230406A1
CA3230406A1 CA3230406A CA3230406A CA3230406A1 CA 3230406 A1 CA3230406 A1 CA 3230406A1 CA 3230406 A CA3230406 A CA 3230406A CA 3230406 A CA3230406 A CA 3230406A CA 3230406 A1 CA3230406 A1 CA 3230406A1
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Prior art keywords
mva
mirblock
seq
rsv
mir
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CA3230406A
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English (en)
French (fr)
Inventor
Jurgen Hausmann
Markus Kalla
Marc Schweneker
Matthias Habjan
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Bavarian Nordic AS
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Bavarian Nordic AS
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
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    • C12N2710/24011—Poxviridae
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    • C12N2760/00011—Details
    • C12N2760/00022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA3230406A 2021-09-03 2022-09-02 Utilization of micro-rna for downregulation of cytotoxic transgene expression by modified vaccinia virus ankara (mva) Pending CA3230406A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21194940.9 2021-09-03
EP21194940 2021-09-03
PCT/EP2022/074510 WO2023031428A1 (en) 2021-09-03 2022-09-02 Utilization of micro-rna for downregulation of cytotoxic transgene expression by modified vaccinia virus ankara (mva)

Publications (1)

Publication Number Publication Date
CA3230406A1 true CA3230406A1 (en) 2023-03-09

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CA3230406A Pending CA3230406A1 (en) 2021-09-03 2022-09-02 Utilization of micro-rna for downregulation of cytotoxic transgene expression by modified vaccinia virus ankara (mva)

Country Status (10)

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US (1) US20240392257A1 (enExample)
EP (1) EP4396333A1 (enExample)
JP (1) JP2024535145A (enExample)
KR (1) KR20240051214A (enExample)
CN (1) CN118234850A (enExample)
AU (1) AU2022338199A1 (enExample)
CA (1) CA3230406A1 (enExample)
IL (1) IL311078A (enExample)
MX (1) MX2024002641A (enExample)
WO (1) WO2023031428A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025153852A1 (en) * 2024-01-17 2025-07-24 1. Revvity Gene Delivery Gmbh Production of viral vectors

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024188801A1 (en) * 2023-03-10 2024-09-19 Bavarian Nordic A/S Use of quail cell lines for poxvirus production
WO2024245722A2 (en) * 2023-05-26 2024-12-05 Probiogen Ag Rapid selection system for the generation of recombinant enveloped viruses
AU2024396470A1 (en) * 2023-12-08 2026-06-04 Bavarian Nordic A/S Downregulation of yield-reducing transgenes expressed by poxvirus

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU230198B1 (hu) 2000-11-23 2015-10-28 Bavarian Nordic A/S Módosított Vacciniavírus Ankara-variáns
EP1456230A2 (en) 2001-12-04 2004-09-15 Bavarian Nordic A/S Flavivirus ns1 subunit vaccine
US20060185027A1 (en) * 2004-12-23 2006-08-17 David Bartel Systems and methods for identifying miRNA targets and for altering miRNA and target expression
US20100261175A1 (en) * 2007-06-15 2010-10-14 Exiqon A/S Use of short oligonucleotides for reagent redundancy experiments in rna functional analysis
US8883995B2 (en) * 2009-03-06 2014-11-11 Icahn School Of Medicine At Mount Sinai Live attenuated influenza virus vaccines comprising microRNA response elements
GB2469043B (en) * 2009-03-30 2011-02-23 Lotus Car A reheated gas turbine system having a fuel cell
US20130280215A1 (en) * 2011-10-18 2013-10-24 Geovax, Inc. Mva vectors expressing polypeptides and having high level production in certain cell lines
SI2879702T1 (sl) * 2012-08-01 2020-02-28 Bavarian Nordic A/S Cepivo na osnovi rekombinantnega modificiranega virusa vakcinacije Ankara (MVA) proti respiratornemu sincitialnemu virusu (RSV)
MX380483B (es) 2012-10-28 2025-03-12 Bavarian Nordic As Promotor pr13.5 para respuestas de anticuerpos y linfocitos t fuertes.
CN106636310B (zh) * 2015-10-30 2020-06-02 益善生物技术股份有限公司 前列腺癌相关microRNA检测试剂盒
CN106636315B (zh) * 2015-10-30 2020-06-02 益善生物技术股份有限公司 淋巴瘤相关microRNA检测试剂盒

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025153852A1 (en) * 2024-01-17 2025-07-24 1. Revvity Gene Delivery Gmbh Production of viral vectors

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AU2022338199A1 (en) 2024-03-14
CN118234850A (zh) 2024-06-21
JP2024535145A (ja) 2024-09-27
KR20240051214A (ko) 2024-04-19
EP4396333A1 (en) 2024-07-10
WO2023031428A1 (en) 2023-03-09
US20240392257A1 (en) 2024-11-28
MX2024002641A (es) 2024-05-10
IL311078A (en) 2024-04-01

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