CA3228331A1 - Generation et caracterisation de nouveaux agents de liaison a tim-4 - Google Patents

Generation et caracterisation de nouveaux agents de liaison a tim-4 Download PDF

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Publication number
CA3228331A1
CA3228331A1 CA3228331A CA3228331A CA3228331A1 CA 3228331 A1 CA3228331 A1 CA 3228331A1 CA 3228331 A CA3228331 A CA 3228331A CA 3228331 A CA3228331 A CA 3228331A CA 3228331 A1 CA3228331 A1 CA 3228331A1
Authority
CA
Canada
Prior art keywords
seq
variant
cancer
composition
mutations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3228331A
Other languages
English (en)
Inventor
Karla FRIETZE
Padmini JAYARAMAN
Matthew Seavey
John Prendergast
Neil Goldstein
Jeffrey Wolf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scorpius Holdings Inc
Original Assignee
Heat Biologics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heat Biologics Inc filed Critical Heat Biologics Inc
Publication of CA3228331A1 publication Critical patent/CA3228331A1/fr
Pending legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La divulgation concerne des compositions qui se lient en particulier à Tim-4 ainsi que leurs méthodes d'utilisation.
CA3228331A 2021-08-10 2022-08-09 Generation et caracterisation de nouveaux agents de liaison a tim-4 Pending CA3228331A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163231455P 2021-08-10 2021-08-10
US63/231,455 2021-08-10
PCT/US2022/074712 WO2023019137A1 (fr) 2021-08-10 2022-08-09 Génération et caractérisation de nouveaux agents de liaison à tim-4

Publications (1)

Publication Number Publication Date
CA3228331A1 true CA3228331A1 (fr) 2023-02-16

Family

ID=85200369

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3228331A Pending CA3228331A1 (fr) 2021-08-10 2022-08-09 Generation et caracterisation de nouveaux agents de liaison a tim-4

Country Status (5)

Country Link
EP (1) EP4384552A1 (fr)
JP (1) JP2024530656A (fr)
CN (1) CN117897408A (fr)
CA (1) CA3228331A1 (fr)
WO (1) WO2023019137A1 (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109641968B (zh) * 2016-07-06 2023-10-20 百时美施贵宝公司 Tim-4拮抗剂和pd-1拮抗剂的组合及其使用方法
AU2018276409A1 (en) * 2017-05-31 2019-10-31 Boehringer Ingelheim International Gmbh Polypeptides antagonizing Wnt signaling in tumor cells

Also Published As

Publication number Publication date
JP2024530656A (ja) 2024-08-23
EP4384552A1 (fr) 2024-06-19
CN117897408A (zh) 2024-04-16
WO2023019137A1 (fr) 2023-02-16

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