CA3225704A1 - Pharmacological agents for preventing and treating cataracts and presbyopia eye diseases - Google Patents
Pharmacological agents for preventing and treating cataracts and presbyopia eye diseases Download PDFInfo
- Publication number
- CA3225704A1 CA3225704A1 CA3225704A CA3225704A CA3225704A1 CA 3225704 A1 CA3225704 A1 CA 3225704A1 CA 3225704 A CA3225704 A CA 3225704A CA 3225704 A CA3225704 A CA 3225704A CA 3225704 A1 CA3225704 A1 CA 3225704A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- ona
- pharmaceutically acceptable
- alkyl
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163215818P | 2021-06-28 | 2021-06-28 | |
| US63/215,818 | 2021-06-28 | ||
| PCT/US2022/035336 WO2023278464A1 (en) | 2021-06-28 | 2022-06-28 | Pharmacological agents for preventing and treating cataracts and presbyopia eye diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3225704A1 true CA3225704A1 (en) | 2023-01-05 |
Family
ID=84692077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3225704A Pending CA3225704A1 (en) | 2021-06-28 | 2022-06-28 | Pharmacological agents for preventing and treating cataracts and presbyopia eye diseases |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20240327439A1 (https=) |
| EP (1) | EP4362923A4 (https=) |
| JP (1) | JP2024524433A (https=) |
| CN (2) | CN116963727A (https=) |
| CA (1) | CA3225704A1 (https=) |
| MX (1) | MX2024000116A (https=) |
| WO (1) | WO2023278464A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11872236B2 (en) | 2018-04-05 | 2024-01-16 | Calasia Pharmaceuticals, Inc. | Pharmacological agents for treating ocular diseases |
| EP4243798A4 (en) * | 2020-11-13 | 2024-08-21 | Plex Pharmaceuticals, Inc. | PHARMACOLOGICAL AGENTS FOR TREATING OCULAR PATHOLOGIES |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ID19540A (id) * | 1997-01-22 | 1998-07-23 | Hoffmann La Roche | Metode pembuatan turunan-turunan benzofenon |
| US20010044584A1 (en) * | 1997-08-28 | 2001-11-22 | Kensey Kenneth R. | In vivo delivery methods and compositions |
| KR20060013632A (ko) * | 2002-05-17 | 2006-02-13 | 오쎄라 파마슈티걸즈, 인크. | 백내장 및 다른 안질환 발병의 개선 |
| WO2014164667A1 (en) * | 2013-03-11 | 2014-10-09 | Georgetown University | Dengue and west nile virus protease inhibitors |
| WO2018036498A1 (en) * | 2016-08-24 | 2018-03-01 | National Institute Of Biological Sciences, Beijing | Entacapone-related compounds to treat macular degeneration |
| US11872236B2 (en) * | 2018-04-05 | 2024-01-16 | Calasia Pharmaceuticals, Inc. | Pharmacological agents for treating ocular diseases |
| KR20230021002A (ko) * | 2020-06-09 | 2023-02-13 | 에이에스엠엘 홀딩 엔.브이. | 내장 동축 조명부를 갖는 리소그래피 사전-정렬 이미징 센서 |
| EP4243798A4 (en) * | 2020-11-13 | 2024-08-21 | Plex Pharmaceuticals, Inc. | PHARMACOLOGICAL AGENTS FOR TREATING OCULAR PATHOLOGIES |
-
2021
- 2021-11-15 CN CN202180090238.6A patent/CN116963727A/zh active Pending
-
2022
- 2022-06-28 CA CA3225704A patent/CA3225704A1/en active Pending
- 2022-06-28 MX MX2024000116A patent/MX2024000116A/es unknown
- 2022-06-28 CN CN202280058201.XA patent/CN117915900A/zh active Pending
- 2022-06-28 US US18/575,218 patent/US20240327439A1/en active Pending
- 2022-06-28 JP JP2023580804A patent/JP2024524433A/ja active Pending
- 2022-06-28 WO PCT/US2022/035336 patent/WO2023278464A1/en not_active Ceased
- 2022-06-28 EP EP22834075.8A patent/EP4362923A4/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| MX2024000116A (es) | 2024-06-19 |
| WO2023278464A1 (en) | 2023-01-05 |
| US20240327439A1 (en) | 2024-10-03 |
| CN116963727A (zh) | 2023-10-27 |
| JP2024524433A (ja) | 2024-07-05 |
| EP4362923A4 (en) | 2025-03-19 |
| EP4362923A1 (en) | 2024-05-08 |
| CN117915900A (zh) | 2024-04-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2011259997B2 (en) | N-acetyl-DL-leucine, neuroprotective and retinoprotective medicament | |
| CA2909160C (en) | Formulations of oxabicycloheptanes and oxabicycloheptenes | |
| CA3225704A1 (en) | Pharmacological agents for preventing and treating cataracts and presbyopia eye diseases | |
| US9713597B2 (en) | Stable aqueous formulation of (E)-4-carboxystyryl-4-chlorobenzyl sulfone | |
| IT8149790A1 (it) | Un nuovo trattamento della cataratta | |
| CN101151034A (zh) | 含有前列腺素F2α衍生物作为有效成分的视网膜神经细胞保护剂 | |
| CA3005714A1 (en) | Triaryl methane composition, dye composition for ocular membrane dyeing | |
| ES2860767T3 (es) | Mirabegrón para el tratamiento de enfermedades retinianas | |
| IT9020968A1 (it) | Composto farmaceutico a base di un antocianidina per il trattamento di malattie oftalmiche | |
| US20220389023A1 (en) | Compounds, compositions, and methods for protein degradation | |
| US20250019352A1 (en) | Pharmacological agents for treating ophthalmic diseases | |
| BR112012022349B1 (pt) | Composto, método para tratar uma doença, e, processo | |
| JP5969872B2 (ja) | フラビンアデニンジヌクレオチドまたはその塩を有効成分として含有する角膜上皮細胞死の抑制剤 | |
| EP2762144B1 (en) | Combination of hyaluronic acid and flavin adenine dinucleotide for use in inhibiting corneal epithelial cell death | |
| WO2025090994A1 (en) | Compositions for treating cataracts and/or presbyopia eye diseases | |
| US3824313A (en) | Topical opthalmic composition and methods of use | |
| WO1994003167A1 (fr) | Remede contre la cataracte | |
| TWI901889B (zh) | 胱胺的用途 | |
| EP4302760A1 (en) | Aspirin-mimetic antioxidants for treatment of age-related cataract | |
| RU2245138C1 (ru) | Способ лечения глазных заболеваний и глазные капли и глазная мазь для его осуществления | |
| WO2011162633A1 (ru) | Мягкие катионные митохондриальные разобщители | |
| CN115068466A (zh) | 7，4′二羟基-8-甲氧基高异黄烷防治帕金森病的应用 | |
| US20260103485A1 (en) | Compound based on oxidative stress and anti-amyloid aggregation mechanism, preparation method therefor and use thereof | |
| PL136417B1 (en) | Method of obtaining novel /1-benzyl-1h-indazolyloxy-3/acetic salt with lysine | |
| JP2020015707A (ja) | 水泡性角膜症治療用医薬組成物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| P22 | Classification modified |
Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P22-P110 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CLASSIFICATION MODIFIED Effective date: 20241126 |
|
| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 3RD ANNIV.) - STANDARD Year of fee payment: 3 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250625 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20250625 |