CA3225480A1 - Compositions lyophilisees a surface specifique elevee comprenant de l'arsenic destinees a une administration orale chez des patients - Google Patents

Compositions lyophilisees a surface specifique elevee comprenant de l'arsenic destinees a une administration orale chez des patients Download PDF

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Publication number
CA3225480A1
CA3225480A1 CA3225480A CA3225480A CA3225480A1 CA 3225480 A1 CA3225480 A1 CA 3225480A1 CA 3225480 A CA3225480 A CA 3225480A CA 3225480 A CA3225480 A CA 3225480A CA 3225480 A1 CA3225480 A1 CA 3225480A1
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CA
Canada
Prior art keywords
arsenic
minutes
millitorrs
product
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3225480A
Other languages
English (en)
Inventor
Kumar KURUMADDALI
Krishna Vaddi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syros Pharmaceuticals Inc
Original Assignee
Syros Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syros Pharmaceuticals Inc filed Critical Syros Pharmaceuticals Inc
Publication of CA3225480A1 publication Critical patent/CA3225480A1/fr
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/36Arsenic; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3225480A 2015-02-01 2016-02-01 Compositions lyophilisees a surface specifique elevee comprenant de l'arsenic destinees a une administration orale chez des patients Pending CA3225480A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562110574P 2015-02-01 2015-02-01
US62/110,574 2015-02-01
US201562142709P 2015-04-03 2015-04-03
US62/142,709 2015-04-03
CA2975406A CA2975406A1 (fr) 2015-02-01 2016-02-01 Compositions lyophilisees a surface specifique elevee comprenant de l'arsenic destinees a une administration orale chez des patients

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2975406A Division CA2975406A1 (fr) 2015-02-01 2016-02-01 Compositions lyophilisees a surface specifique elevee comprenant de l'arsenic destinees a une administration orale chez des patients

Publications (1)

Publication Number Publication Date
CA3225480A1 true CA3225480A1 (fr) 2016-08-04

Family

ID=56544541

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2975406A Pending CA2975406A1 (fr) 2015-02-01 2016-02-01 Compositions lyophilisees a surface specifique elevee comprenant de l'arsenic destinees a une administration orale chez des patients
CA3225480A Pending CA3225480A1 (fr) 2015-02-01 2016-02-01 Compositions lyophilisees a surface specifique elevee comprenant de l'arsenic destinees a une administration orale chez des patients

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA2975406A Pending CA2975406A1 (fr) 2015-02-01 2016-02-01 Compositions lyophilisees a surface specifique elevee comprenant de l'arsenic destinees a une administration orale chez des patients

Country Status (12)

Country Link
US (5) US10111836B2 (fr)
EP (2) EP3250214B1 (fr)
JP (2) JP6928768B2 (fr)
CN (2) CN117899029A (fr)
AU (3) AU2016211186A1 (fr)
CA (2) CA2975406A1 (fr)
ES (1) ES2899226T3 (fr)
HK (1) HK1248113A1 (fr)
MX (2) MX2017009913A (fr)
NZ (1) NZ734201A (fr)
TW (3) TW202228734A (fr)
WO (1) WO2016123603A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201903064SA (en) * 2016-12-01 2019-05-30 Eupharma Pty Ltd Arsenic compositions
KR101844049B1 (ko) * 2016-12-05 2018-03-30 주식회사 케마스 육산화사비소의 결정다형을 포함하는 간암 예방 또는 치료용 약학 조성물
KR101844050B1 (ko) 2016-12-09 2018-05-14 주식회사 케마스 육산화사비소의 결정다형을 포함하는 암 예방 또는 치료용 약학 조성물
WO2018134260A1 (fr) * 2017-01-18 2018-07-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques permettant le traitement de patients souffrant de troubles myéloprolifératifs
US11583552B2 (en) 2021-02-17 2023-02-21 Manoj Maniar Pharmaceutical formulation of arsenic trioxide

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1044559C (zh) 1995-08-23 1999-08-11 哈尔滨医科大学附属第一医院 抗白血病、肝癌、淋巴瘤注射液
EP1964557B1 (fr) 1997-11-10 2013-01-02 Memorial Sloan-Kettering Cancer Center Procédé de production de formulations à base de trioxide d'arsenic
US7276359B1 (en) * 1998-03-13 2007-10-02 Wyeth Polynucleotide composition, method of preparation, and use thereof
CN1131922C (zh) 1998-10-19 2003-12-24 张在喆 一种通过弹性键搭架与收拢的帐篷
US7374779B2 (en) 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
CN1310999A (zh) * 2000-02-29 2001-09-05 布里斯托尔-迈尔斯斯奎布公司 低剂量艾替开韦制剂及其应用
AUPR874601A0 (en) * 2001-11-08 2001-11-29 Unisearch Limited Selective targeting of apoptotic cells
US7521071B2 (en) * 2002-10-09 2009-04-21 Versitech Limited Formulation of oral compositions comprising arsenic trioxide and methods of use thereof
US8906422B2 (en) 2002-10-09 2014-12-09 The University Of Hong Kong Method for inhibiting cancer using arsenic trioxide
GB0315632D0 (en) * 2003-07-04 2003-08-13 West Pharm Serv Drug Res Ltd Pharmaceutical formulations
CN1251688C (zh) 2003-12-09 2006-04-19 重庆维特瑞医药开发有限公司 三氧化二砷冻干粉针及其生产方法
CN1698650A (zh) 2004-05-21 2005-11-23 哈尔滨伊达药业有限公司 一种治疗原发性肝癌的亚砷酸注射液及其制备方法
CN1326528C (zh) 2004-07-13 2007-07-18 东南大学 砒霜磁性纳米明胶微球的制备工艺
RS20080167A (en) 2005-10-21 2009-07-15 Panacea Biotec Limited, Novel improved compositions for cancer therapy
US20080089951A1 (en) * 2006-10-11 2008-04-17 The University Of Hong Kong Method for Inhibiting Cancer Using Arsenic Trioxide
CN101322719B (zh) 2007-06-15 2012-03-07 杭州民生药业有限公司 一种三氧化二砷固体脂质纳米粒及其制剂
US8168224B2 (en) * 2007-12-19 2012-05-01 Beijing Shengyiyao Science & Technology Development Co., Ltd. Sodium alginate microsphere vascular embolus containing water-soluble drug and preparation and application thereof
EP2359812A1 (fr) * 2010-01-18 2011-08-24 Cephalon France Compositions orales lyophilisées
CN103142648B (zh) 2011-12-07 2015-04-15 浙江中医药大学 一种砷化合物溶液及其制备的包载砷化合物的白蛋白纳米粒和冻干制剂
CN103408477B (zh) 2013-08-22 2015-06-10 陈鹏飞 一种含砷配位化合物及其制备方法

Also Published As

Publication number Publication date
US20200060974A1 (en) 2020-02-27
US20160235679A1 (en) 2016-08-18
JP2021152059A (ja) 2021-09-30
EP3250214B1 (fr) 2021-09-01
AU2016211186A1 (en) 2017-08-17
ES2899226T3 (es) 2022-03-10
WO2016123603A3 (fr) 2016-11-03
US10272045B2 (en) 2019-04-30
EP3250214A2 (fr) 2017-12-06
US20230310325A1 (en) 2023-10-05
TWI790191B (zh) 2023-01-21
AU2021203752A1 (en) 2021-07-08
WO2016123603A2 (fr) 2016-08-04
HK1248113A1 (zh) 2018-10-12
TW202228734A (zh) 2022-08-01
US20190029963A1 (en) 2019-01-31
MX2017009913A (es) 2018-08-15
TW201642879A (zh) 2016-12-16
AU2023214307A1 (en) 2023-08-31
JP6928768B2 (ja) 2021-09-01
EP3981414A1 (fr) 2022-04-13
CN107530373A (zh) 2018-01-02
CN107530373B (zh) 2023-12-29
TW202337477A (zh) 2023-10-01
US10111836B2 (en) 2018-10-30
AU2021203752B2 (en) 2023-08-31
EP3250214A4 (fr) 2018-09-19
CN117899029A (zh) 2024-04-19
US20210069115A1 (en) 2021-03-11
JP2018503696A (ja) 2018-02-08
US10653628B2 (en) 2020-05-19
CA2975406A1 (fr) 2016-08-04
NZ734201A (en) 2024-03-22
MX2020012611A (es) 2021-02-09

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Effective date: 20240404