CA3223100A1 - Systeme de distribution d'ionophore chimique a membrane cellulaire synthetique comprenant des compositions de ligand hexa-eau - Google Patents
Systeme de distribution d'ionophore chimique a membrane cellulaire synthetique comprenant des compositions de ligand hexa-eau Download PDFInfo
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- CA3223100A1 CA3223100A1 CA3223100A CA3223100A CA3223100A1 CA 3223100 A1 CA3223100 A1 CA 3223100A1 CA 3223100 A CA3223100 A CA 3223100A CA 3223100 A CA3223100 A CA 3223100A CA 3223100 A1 CA3223100 A1 CA 3223100A1
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- VSZWPYCFIRKVQL-UHFFFAOYSA-N selanylidenegallium;selenium Chemical compound [Se].[Se]=[Ga].[Se]=[Ga] VSZWPYCFIRKVQL-UHFFFAOYSA-N 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000001235 sensitizing effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 230000007781 signaling event Effects 0.000 description 1
- 230000009131 signaling function Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000010944 silver (metal) Substances 0.000 description 1
- 238000009097 single-agent therapy Methods 0.000 description 1
- 201000009890 sinusitis Diseases 0.000 description 1
- 229940126586 small molecule drug Drugs 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000000050 smooth muscle relaxant Substances 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 210000003699 striated muscle Anatomy 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 238000012385 systemic delivery Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229910052715 tantalum Inorganic materials 0.000 description 1
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 1
- 229910052713 technetium Inorganic materials 0.000 description 1
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 1
- JBQYATWDVHIOAR-UHFFFAOYSA-N tellanylidenegermanium Chemical compound [Te]=[Ge] JBQYATWDVHIOAR-UHFFFAOYSA-N 0.000 description 1
- 229910052714 tellurium Inorganic materials 0.000 description 1
- PORWMNRCUJJQNO-UHFFFAOYSA-N tellurium atom Chemical compound [Te] PORWMNRCUJJQNO-UHFFFAOYSA-N 0.000 description 1
- 108091035539 telomere Proteins 0.000 description 1
- 210000003411 telomere Anatomy 0.000 description 1
- 102000055501 telomere Human genes 0.000 description 1
- 201000003120 testicular cancer Diseases 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000003582 thrombocytopenic effect Effects 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 201000002510 thyroid cancer Diseases 0.000 description 1
- 210000001578 tight junction Anatomy 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000009092 tissue dysfunction Effects 0.000 description 1
- 201000006134 tongue cancer Diseases 0.000 description 1
- 239000008009 topical excipient Substances 0.000 description 1
- 229940042129 topical gel Drugs 0.000 description 1
- 229940126702 topical medication Drugs 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 238000013271 transdermal drug delivery Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 229910001428 transition metal ion Inorganic materials 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 230000007723 transport mechanism Effects 0.000 description 1
- 208000009174 transverse myelitis Diseases 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 208000022679 triple-negative breast carcinoma Diseases 0.000 description 1
- 230000001573 trophoblastic effect Effects 0.000 description 1
- 230000005740 tumor formation Effects 0.000 description 1
- 230000005751 tumor progression Effects 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 230000004143 urea cycle Effects 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
- 206010046885 vaginal cancer Diseases 0.000 description 1
- 208000013139 vaginal neoplasm Diseases 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 201000005102 vulva cancer Diseases 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 208000036440 well differentiated low or intermediate grade neuroendocrine tumor of rectum Diseases 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1
- 229940006486 zinc cation Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
L'invention concerne des ionophores synthétiques pour l'acheminement et le transport actifs d'ions libres à travers des membranes biologiques in vivo, comprenant des complexes de coordination de molécules avec des systèmes hexa-eau et/ou tétra-eau polarisés de métaux ioniques libres et de sels ioniques en tant qu'ionophores, utiles dans le transport de composés pharmaceutiques, nutritifs et de soins de santé personnels. L'invention concerne également des procédés d'administration de ceux-ci, des procédés de synthèse et de fabrication de ceux-ci, et les produits ionophores issus de tels procédés de synthèse et de fabrication.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202117349880A | 2021-06-16 | 2021-06-16 | |
US17/349,880 | 2021-06-16 | ||
US17/390,743 US20220226371A1 (en) | 2021-01-13 | 2021-07-30 | Synthetic Cellular Membrane Chemical Ionophore Delivery System Comprising Hexa-Aqua Ligand Compositions |
US17/390,743 | 2021-07-30 | ||
PCT/US2022/030607 WO2022265829A1 (fr) | 2021-06-16 | 2022-05-23 | Système de distribution d'ionophore chimique à membrane cellulaire synthétique comprenant des compositions de ligand hexa-eau |
Publications (1)
Publication Number | Publication Date |
---|---|
CA3223100A1 true CA3223100A1 (fr) | 2022-12-22 |
Family
ID=84527605
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3223100A Pending CA3223100A1 (fr) | 2021-06-16 | 2022-05-23 | Systeme de distribution d'ionophore chimique a membrane cellulaire synthetique comprenant des compositions de ligand hexa-eau |
Country Status (5)
Country | Link |
---|---|
AU (1) | AU2022291691A1 (fr) |
CA (1) | CA3223100A1 (fr) |
DE (1) | DE112022002702T5 (fr) |
GB (1) | GB2622558A (fr) |
WO (1) | WO2022265829A1 (fr) |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5753031A (en) * | 1996-09-27 | 1998-05-19 | W. R. Grace & Co.-Conn. | Composition and method to remove asbestos |
GB9929255D0 (en) * | 1999-12-11 | 2000-02-02 | British Nuclear Fuels Plc | Compound |
FR2843752B1 (fr) * | 2002-08-26 | 2007-05-18 | Pancosma Sa Pour L Ind Des Pro | Oligo-elements cristallins, et procedes pour leur fabrication |
JP4185311B2 (ja) * | 2002-05-10 | 2008-11-26 | 新興化学工業株式会社 | バナジウムレドックスフロー電池電解液用固形組成物 |
WO2015122250A1 (fr) * | 2014-02-17 | 2015-08-20 | 三菱瓦斯化学株式会社 | Composition liquide de gravure d'oxydes comprenant l'indium, le zinc, l'étain et de l'oxygène, et procédé de gravure |
CA3080157A1 (fr) * | 2017-10-26 | 2019-05-02 | Array Biopharma Inc. | Formulations d'un inhibiteur de kinase trk macrocyclique |
IN201813025436A (fr) * | 2018-07-07 | 2020-01-10 | Balendu Prakash Vaidya |
-
2022
- 2022-05-23 WO PCT/US2022/030607 patent/WO2022265829A1/fr active Application Filing
- 2022-05-23 CA CA3223100A patent/CA3223100A1/fr active Pending
- 2022-05-23 AU AU2022291691A patent/AU2022291691A1/en active Pending
- 2022-05-23 DE DE112022002702.9T patent/DE112022002702T5/de active Pending
- 2022-05-23 GB GB2400617.3A patent/GB2622558A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
GB2622558A (en) | 2024-03-20 |
GB202400617D0 (en) | 2024-02-28 |
DE112022002702T5 (de) | 2024-04-18 |
WO2022265829A1 (fr) | 2022-12-22 |
AU2022291691A1 (en) | 2024-02-01 |
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