CA3215842A1 - Chimeric antigen receptor (car)-t cells - Google Patents

Chimeric antigen receptor (car)-t cells Download PDF

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Publication number
CA3215842A1
CA3215842A1 CA3215842A CA3215842A CA3215842A1 CA 3215842 A1 CA3215842 A1 CA 3215842A1 CA 3215842 A CA3215842 A CA 3215842A CA 3215842 A CA3215842 A CA 3215842A CA 3215842 A1 CA3215842 A1 CA 3215842A1
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Prior art keywords
cells
cell
car
construct
seq
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CA3215842A
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English (en)
French (fr)
Inventor
Xiaoning Xu
Weiwei Ma
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Ip2ipo Innovations Ltd
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Imperial College Innovations Ltd
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Publication of CA3215842A1 publication Critical patent/CA3215842A1/en
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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CA3215842A 2021-04-21 2022-04-21 Chimeric antigen receptor (car)-t cells Pending CA3215842A1 (en)

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Application Number Priority Date Filing Date Title
GB2105686.6 2021-04-21
GBGB2105686.6A GB202105686D0 (en) 2021-04-21 2021-04-21 Chimeric antigen receptor (CAR)-T cells
PCT/GB2022/051004 WO2022223976A1 (en) 2021-04-21 2022-04-21 Chimeric antigen receptor (car)-t cells

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CA3215842A1 true CA3215842A1 (en) 2022-10-27

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CA3215842A Pending CA3215842A1 (en) 2021-04-21 2022-04-21 Chimeric antigen receptor (car)-t cells

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US (1) US20240207313A1 (enExample)
EP (1) EP4326760A1 (enExample)
JP (1) JP2024515347A (enExample)
KR (1) KR20240032719A (enExample)
CN (1) CN117769566A (enExample)
AU (1) AU2022262697A1 (enExample)
CA (1) CA3215842A1 (enExample)
GB (1) GB202105686D0 (enExample)
WO (1) WO2022223976A1 (enExample)

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US10245262B2 (en) 2014-04-01 2019-04-02 The University Of Queensland Immunological reagents and uses therefor
GB201506423D0 (en) * 2015-04-15 2015-05-27 Tc Biopharm Ltd Gamma delta T cells and uses thereof
ES2851123T1 (es) * 2014-09-26 2021-09-03 Baylor College Medicine Receptores quiméricos de antígeno específicos de glipicano-3 para inmunoterapia adoptiva
CA2977106A1 (en) * 2015-02-27 2016-09-01 Icell Gene Therapeutics Llc Chimeric antigen receptors (cars) targeting hematologic malignancies, compositions and methods of use thereof
CN109897114B (zh) * 2017-12-08 2022-08-02 亘喜生物科技(上海)有限公司 具有自杀基因开关的靶向cd47的工程化免疫细胞
GB201800298D0 (en) * 2018-01-09 2018-02-21 Autolus Ltd Method
CN113286875B (zh) * 2018-12-19 2024-08-09 Inserm(法国国家健康医学研究院) 表达嵌合抗原受体的黏膜相关不变t(mait)细胞
WO2020156335A1 (zh) * 2019-01-29 2020-08-06 上海交通大学 一种嵌合抗原受体及其应用
WO2021155112A1 (en) * 2020-01-29 2021-08-05 The Trustees Of The University Of Pennsylvania Compositions and methods of t cell receptor vb family member targeting for the treatment of t cell associated disease

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