JP2024515347A - キメラ抗原受容体（ｃａｒ）－ｔ細胞 - Google Patents

キメラ抗原受容体（ｃａｒ）－ｔ細胞 Download PDF

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JP2024515347A
JP2024515347A JP2023564511A JP2023564511A JP2024515347A JP 2024515347 A JP2024515347 A JP 2024515347A JP 2023564511 A JP2023564511 A JP 2023564511A JP 2023564511 A JP2023564511 A JP 2023564511A JP 2024515347 A JP2024515347 A JP 2024515347A
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cells
cell
car
construct
seq
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JP2024515347A5 (enExample
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シュー，シャオニン
マ，ウェイウェイ
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Ip2ipo Innovations Ltd
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Imperial College Innovations Ltd
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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JP2023564511A 2021-04-21 2022-04-21 キメラ抗原受容体（ｃａｒ）－ｔ細胞 Pending JP2024515347A (ja)

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Application Number Priority Date Filing Date Title
GB2105686.6 2021-04-21
GBGB2105686.6A GB202105686D0 (en) 2021-04-21 2021-04-21 Chimeric antigen receptor (CAR)-T cells
PCT/GB2022/051004 WO2022223976A1 (en) 2021-04-21 2022-04-21 Chimeric antigen receptor (car)-t cells

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JP2024515347A true JP2024515347A (ja) 2024-04-09
JP2024515347A5 JP2024515347A5 (enExample) 2025-04-25

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017529851A (ja) * 2014-09-26 2017-10-12 ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ 養子免疫療法のためのグリピカン−３特異的キメラ抗原レセプター
JP2018512161A (ja) * 2015-04-15 2018-05-17 ティーシー バイオファーム リミテッド 修正ガンマデルタｔ細胞およびその使用
JP2018513692A (ja) * 2015-02-27 2018-05-31 アイセル・ジーン・セラピューティクス・エルエルシー 血液系腫瘍を標的としたキメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法
CN109897114A (zh) * 2017-12-08 2019-06-18 亘喜生物科技（上海）有限公司 具有自杀基因开关的靶向cd47的工程化免疫细胞
WO2020127513A1 (en) * 2018-12-19 2020-06-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Mucosal-associated invariant t (mait) cells expressing chimeric antigen receptors
WO2020156335A1 (zh) * 2019-01-29 2020-08-06 上海交通大学 一种嵌合抗原受体及其应用
JP2021509287A (ja) * 2018-01-09 2021-03-25 オートラス リミテッド キメラ抗原受容体（ｃａｒ）またはトランスジェニックｔ細胞受容体（ｔｃｒ）の発現のためのウイルスベクターで細胞を形質導入するための方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10245262B2 (en) 2014-04-01 2019-04-02 The University Of Queensland Immunological reagents and uses therefor
WO2021155112A1 (en) * 2020-01-29 2021-08-05 The Trustees Of The University Of Pennsylvania Compositions and methods of t cell receptor vb family member targeting for the treatment of t cell associated disease

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017529851A (ja) * 2014-09-26 2017-10-12 ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ 養子免疫療法のためのグリピカン−３特異的キメラ抗原レセプター
JP2018513692A (ja) * 2015-02-27 2018-05-31 アイセル・ジーン・セラピューティクス・エルエルシー 血液系腫瘍を標的としたキメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法
JP2018512161A (ja) * 2015-04-15 2018-05-17 ティーシー バイオファーム リミテッド 修正ガンマデルタｔ細胞およびその使用
CN109897114A (zh) * 2017-12-08 2019-06-18 亘喜生物科技（上海）有限公司 具有自杀基因开关的靶向cd47的工程化免疫细胞
JP2021509287A (ja) * 2018-01-09 2021-03-25 オートラス リミテッド キメラ抗原受容体（ｃａｒ）またはトランスジェニックｔ細胞受容体（ｔｃｒ）の発現のためのウイルスベクターで細胞を形質導入するための方法
WO2020127513A1 (en) * 2018-12-19 2020-06-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Mucosal-associated invariant t (mait) cells expressing chimeric antigen receptors
WO2020156335A1 (zh) * 2019-01-29 2020-08-06 上海交通大学 一种嵌合抗原受体及其应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CALLAN, M.F.C., ET AL.: ""A method for producing monoclonal antibodies to human T-cell-receptor ,f-chain variable regions."", PROC. NATL. ACAD. SCI. USA, vol. 90, no. 22, JPN6026012184, 3 August 1993 (1993-08-03), pages 10454 - 10458, ISSN: 0005831085 *
MACIOCIA, P.M., ET AL.: ""Targeting the T cell receptor g-chain constant region for immunotherapy of T cell malignancies."", NATURE MEDICINE, vol. 23, no. 12, JPN6026012183, 31 December 2017 (2017-12-31), pages 1416 - 1423, ISSN: 0005831084 *

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