CA3203461A1 - Enhancing mitochondrial-based flow and catabolism of cholesterol - Google Patents

Enhancing mitochondrial-based flow and catabolism of cholesterol

Info

Publication number
CA3203461A1
CA3203461A1 CA3203461A CA3203461A CA3203461A1 CA 3203461 A1 CA3203461 A1 CA 3203461A1 CA 3203461 A CA3203461 A CA 3203461A CA 3203461 A CA3203461 A CA 3203461A CA 3203461 A1 CA3203461 A1 CA 3203461A1
Authority
CA
Canada
Prior art keywords
cell
protein
cholesterol
star
cdp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3203461A
Other languages
English (en)
French (fr)
Inventor
Mourad Topors
Reason
Guilherme Cherman PERDIGAO DE OLIVEIRA
Marc RIDILLA
David MACKENZIE-LIU
Garrett STROUGH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Repair Biotechnologies Inc
Original Assignee
Repair Biotechnologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Repair Biotechnologies Inc filed Critical Repair Biotechnologies Inc
Publication of CA3203461A1 publication Critical patent/CA3203461A1/en
Pending legal-status Critical Current

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    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/443—Oxidoreductases (1) acting on CH-OH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/09—Recombinant DNA-technology
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
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    • C12Y114/15006—Cholesterol monooxygenase (side-chain-cleaving) (1.14.15.6), i.e. cytochrome P450scc
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CA3203461A 2020-12-08 2021-12-08 Enhancing mitochondrial-based flow and catabolism of cholesterol Pending CA3203461A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063122886P 2020-12-08 2020-12-08
US63/122,886 2020-12-08
PCT/US2021/062389 WO2022125653A1 (en) 2020-12-08 2021-12-08 Enhancing mitochondrial-based flow and catabolism of cholesterol

Publications (1)

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CA3203461A1 true CA3203461A1 (en) 2022-06-16

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CA3203461A Pending CA3203461A1 (en) 2020-12-08 2021-12-08 Enhancing mitochondrial-based flow and catabolism of cholesterol

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US (1) US20240050592A1 (https=)
EP (1) EP4259802A4 (https=)
JP (1) JP2023552800A (https=)
CN (1) CN116723869A (https=)
AU (1) AU2021394760A1 (https=)
CA (1) CA3203461A1 (https=)
WO (1) WO2022125653A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11612619B2 (en) 2018-11-01 2023-03-28 National Institute Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs), U.S. Government Compostions and methods for enabling cholesterol catabolism in human cells
US12544402B2 (en) 2020-02-28 2026-02-10 Repair Biotechnologies, Inc. Targeted expression of microbial cholesterol catalysis genes reduces excess lipid

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6903183B1 (en) * 1996-06-07 2005-06-07 Texas Tech University Health Services Center Compositions and methods for regulation of steroidogenesis
CA2349761A1 (en) * 1998-11-06 2000-05-18 Incyte Pharmaceuticals, Inc. Corticosteroid synthesis-associated genes
AU2003253606A1 (en) * 2002-05-20 2003-12-12 Regents Of The University Of California Methods and compositions for regulation and manipulation of steroidogenesis
JP2005531305A (ja) * 2002-06-10 2005-10-20 エヴォテック ニューロサイエンシス ゲゼルシャフト ミット ベシュレンクテル ハフツング ステロイド産生急性調節タンパク質の神経変性疾患に関する診断的および治療的使用
US11612619B2 (en) * 2018-11-01 2023-03-28 National Institute Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs), U.S. Government Compostions and methods for enabling cholesterol catabolism in human cells

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JP2023552800A (ja) 2023-12-19
EP4259802A1 (en) 2023-10-18
CN116723869A (zh) 2023-09-08
EP4259802A4 (en) 2025-02-12
AU2021394760A1 (en) 2023-07-06
US20240050592A1 (en) 2024-02-15
WO2022125653A1 (en) 2022-06-16

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