CA3187086A1 - Methods for reducing glycosphingolipid concentration in brain tissue and methods of treatment of neurodegenerative diseases involving the same - Google Patents
Methods for reducing glycosphingolipid concentration in brain tissue and methods of treatment of neurodegenerative diseases involving the sameInfo
- Publication number
- CA3187086A1 CA3187086A1 CA3187086A CA3187086A CA3187086A1 CA 3187086 A1 CA3187086 A1 CA 3187086A1 CA 3187086 A CA3187086 A CA 3187086A CA 3187086 A CA3187086 A CA 3187086A CA 3187086 A1 CA3187086 A1 CA 3187086A1
- Authority
- CA
- Canada
- Prior art keywords
- subject
- compound
- disease
- concentration
- parkinson
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063059047P | 2020-07-30 | 2020-07-30 | |
| US63/059,047 | 2020-07-30 | ||
| US202063131120P | 2020-12-28 | 2020-12-28 | |
| US63/131,120 | 2020-12-28 | ||
| PCT/IB2021/056971 WO2022024062A1 (en) | 2020-07-30 | 2021-07-30 | Methods for reducing glycosphingolipid concentration in brain tissue and methods of treatment of neurodegenerative diseases involving the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3187086A1 true CA3187086A1 (en) | 2022-02-03 |
Family
ID=77265125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3187086A Pending CA3187086A1 (en) | 2020-07-30 | 2021-07-30 | Methods for reducing glycosphingolipid concentration in brain tissue and methods of treatment of neurodegenerative diseases involving the same |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230372313A1 (https=) |
| EP (1) | EP4188381A1 (https=) |
| JP (1) | JP2023535483A (https=) |
| KR (1) | KR20230047146A (https=) |
| CN (1) | CN116322679A (https=) |
| AU (1) | AU2021317180A1 (https=) |
| BR (1) | BR112023001362A2 (https=) |
| CA (1) | CA3187086A1 (https=) |
| IL (1) | IL300096A (https=) |
| MX (1) | MX2023001285A (https=) |
| WO (1) | WO2022024062A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114040762A (zh) | 2019-02-04 | 2022-02-11 | 建新公司 | 使用葡糖神经酰胺合酶(gcs)的抑制剂治疗纤毛疾病 |
| KR20260021150A (ko) | 2024-08-05 | 2026-02-13 | 충북대학교 산학협력단 | Gba1 돌연변이 보인자의 dj-1 발현수준에 따른 파킨슨병의 위험도 예측 방법 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| KR101987736B1 (ko) * | 2011-03-18 | 2019-06-11 | 젠자임 코포레이션 | 글루코실세라마이드 합성효소 억제제 |
| JO3713B1 (ar) | 2013-03-15 | 2021-01-31 | Genzyme Corp | أشكال ملح (s)-كوينوكليدين-3-يل(2-(2-(4-فلوروفينيل)ثيازول-4-يل)بروبان-2-يل)كارباميت |
| TW201642855A (zh) | 2015-03-10 | 2016-12-16 | 健臻公司 | 用於治療蛋白質病變之方法 |
| US10617713B2 (en) * | 2016-03-08 | 2020-04-14 | Neurocentria, Inc. | Methods of modifying neuronal function by changing intracellular magnesium levels |
| EP3452045A1 (en) * | 2016-05-04 | 2019-03-13 | Lysosomal Therapeutics Inc. | Methods of treatment and combination therapies using gcase activator heterobicyclic and related compounds |
| US10519157B2 (en) * | 2018-02-09 | 2019-12-31 | X-Cutag Therapeutics, Inc. | Deuterated compounds for treating Fabry, Gaucher, Parkinson's and related diseases and conditions, and compositions and methods thereof |
-
2021
- 2021-07-30 US US18/007,433 patent/US20230372313A1/en active Pending
- 2021-07-30 CA CA3187086A patent/CA3187086A1/en active Pending
- 2021-07-30 EP EP21752208.5A patent/EP4188381A1/en active Pending
- 2021-07-30 WO PCT/IB2021/056971 patent/WO2022024062A1/en not_active Ceased
- 2021-07-30 BR BR112023001362A patent/BR112023001362A2/pt unknown
- 2021-07-30 CN CN202180065014.XA patent/CN116322679A/zh active Pending
- 2021-07-30 AU AU2021317180A patent/AU2021317180A1/en active Pending
- 2021-07-30 MX MX2023001285A patent/MX2023001285A/es unknown
- 2021-07-30 JP JP2023505841A patent/JP2023535483A/ja active Pending
- 2021-07-30 KR KR1020237007140A patent/KR20230047146A/ko active Pending
- 2021-07-30 IL IL300096A patent/IL300096A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022024062A1 (en) | 2022-02-03 |
| CN116322679A (zh) | 2023-06-23 |
| EP4188381A1 (en) | 2023-06-07 |
| JP2023535483A (ja) | 2023-08-17 |
| MX2023001285A (es) | 2023-02-22 |
| BR112023001362A2 (pt) | 2023-02-14 |
| IL300096A (en) | 2023-03-01 |
| AU2021317180A1 (en) | 2023-03-23 |
| US20230372313A1 (en) | 2023-11-23 |
| KR20230047146A (ko) | 2023-04-06 |
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