CA3183578A1 - Appelant de base a base d'intelligence artificielle avec reconnaissance contextuelle - Google Patents

Appelant de base a base d'intelligence artificielle avec reconnaissance contextuelle

Info

Publication number
CA3183578A1
CA3183578A1 CA3183578A CA3183578A CA3183578A1 CA 3183578 A1 CA3183578 A1 CA 3183578A1 CA 3183578 A CA3183578 A CA 3183578A CA 3183578 A CA3183578 A CA 3183578A CA 3183578 A1 CA3183578 A1 CA 3183578A1
Authority
CA
Canada
Prior art keywords
intensity
images
context data
neural network
sequencing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3183578A
Other languages
English (en)
Inventor
Amirali Kia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Illumina Inc
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US17/687,586 external-priority patent/US20220319639A1/en
Application filed by Illumina Inc filed Critical Illumina Inc
Publication of CA3183578A1 publication Critical patent/CA3183578A1/fr
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/20—Sequence assembly
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis

Landscapes

  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Health & Medical Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Data Mining & Analysis (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Health & Medical Sciences (AREA)
  • Evolutionary Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Software Systems (AREA)
  • Artificial Intelligence (AREA)
  • Evolutionary Computation (AREA)
  • Epidemiology (AREA)
  • Databases & Information Systems (AREA)
  • Public Health (AREA)
  • Bioethics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Image Analysis (AREA)
  • Two-Way Televisions, Distribution Of Moving Picture Or The Like (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)

Abstract

L'invention concerne un réseau neuronal qui traite des images de séquençage correctif par correctif pour un appel de base. Les images de séquençage représentent des émissions d'intensité d'un ensemble d'analytes. Les correctifs représentent les émissions d'intensité pour un sous-ensemble des analytes et présentent des motifs d'intensité non divers en raison d'une diversité de base limitée. Le réseau neuronal comprend des filtres de convolution qui ont des champs de réception limités aux correctifs. Les filtres de convolution détectent des motifs d'intensité dans les correctifs avec des pertes de détection dues aux motifs d'intensité non divers et aux champs de réception limités. Une unité de contextualisation d'intensité détermine des données de contexte d'intensité sur la base de valeurs d'intensité dans les images. La logique de flux de données ajoute les données de contexte d'intensité aux images de séquençage pour générer des images contextualisées d'intensité. Le réseau neuronal applique les filtres de convolution aux images contextualisées d'intensité et génère des classifications d'appels de base. Les données de contexte d'intensité dans les images contextualisées d'intensité compensent les pertes de détection.
CA3183578A 2021-03-31 2022-03-24 Appelant de base a base d'intelligence artificielle avec reconnaissance contextuelle Pending CA3183578A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163169163P 2021-03-31 2021-03-31
US63/169,163 2021-03-31
US17/687,586 2022-03-04
US17/687,586 US20220319639A1 (en) 2021-03-31 2022-03-04 Artificial intelligence-based base caller with contextual awareness
PCT/US2022/021814 WO2022212180A1 (fr) 2021-03-31 2022-03-24 Appelant de base à base d'intelligence artificielle avec reconnaissance contextuelle

Publications (1)

Publication Number Publication Date
CA3183578A1 true CA3183578A1 (fr) 2022-10-06

Family

ID=81579662

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3183578A Pending CA3183578A1 (fr) 2021-03-31 2022-03-24 Appelant de base a base d'intelligence artificielle avec reconnaissance contextuelle

Country Status (5)

Country Link
EP (1) EP4315343A1 (fr)
CN (1) CN115803816A (fr)
AU (1) AU2022248999A1 (fr)
CA (1) CA3183578A1 (fr)
WO (1) WO2022212180A1 (fr)

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03147799A (ja) 1989-11-02 1991-06-24 Hoechst Japan Ltd 新規なオリゴヌクレオチドプローブ
CN100462433C (zh) 2000-07-07 2009-02-18 维西根生物技术公司 实时序列测定
WO2002044425A2 (fr) 2000-12-01 2002-06-06 Visigen Biotechnologies, Inc. Synthese d'acides nucleiques d'enzymes, et compositions et methodes modifiant la fidelite d'incorporation de monomeres
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
DE10219153A1 (de) 2002-04-29 2003-11-20 Siemens Ag Verfahren zur Überprüfung der Durchgängigkeit von Verbindungen in MPLS-Netzen
US7405251B2 (en) 2002-05-16 2008-07-29 Dow Corning Corporation Flame retardant compositions
WO2004015497A1 (fr) 2002-08-07 2004-02-19 Mitsubishi Chemical Corporation Materiau de formation d'image comportant une couche de materiau de reserve photosensible au laser violet bleuatre et procede de formation d'image de reserve correspondant
WO2004018497A2 (fr) 2002-08-23 2004-03-04 Solexa Limited Nucleotides modifies
GB0321306D0 (en) 2003-09-11 2003-10-15 Solexa Ltd Modified polymerases for improved incorporation of nucleotide analogues
KR100955023B1 (ko) 2003-12-01 2010-04-27 엘지전자 주식회사 디지털 복합 녹화기에서의 데이터 연속 기록방법
WO2005065514A1 (fr) 2004-01-12 2005-07-21 Djibril Soumah Lunette de wc
CN101914620B (zh) 2004-09-17 2014-02-12 加利福尼亚太平洋生命科学公司 核酸测序的方法
US20060111346A1 (en) 2004-11-23 2006-05-25 Fazix Corporation. Methods of modulating high-density lipoprotein cholesterol levels and pharmaceutical formulations for the same
US20060251471A1 (en) 2005-05-06 2006-11-09 Wei-Gen Chen Manual adjustment device for headlamps
DE102005036355A1 (de) 2005-07-29 2007-02-01 Cairos Technologies Ag Verfahren zur Erfassung der Kraft- und Bewegungsverhältnisse an einem Spielgerät
GB0517097D0 (en) 2005-08-19 2005-09-28 Solexa Ltd Modified nucleosides and nucleotides and uses thereof
EP2018622B1 (fr) 2006-03-31 2018-04-25 Illumina, Inc. Systèmes pour analyse de séquençage par synthèse
JPWO2007145365A1 (ja) 2006-06-14 2009-11-12 学校法人自治医科大学 癌治療薬及びそのスクリーニング法
US7414716B2 (en) 2006-10-23 2008-08-19 Emhart Glass S.A. Machine for inspecting glass containers
US8965076B2 (en) 2010-01-13 2015-02-24 Illumina, Inc. Data processing system and methods
US11210554B2 (en) * 2019-03-21 2021-12-28 Illumina, Inc. Artificial intelligence-based generation of sequencing metadata
US11347965B2 (en) * 2019-03-21 2022-05-31 Illumina, Inc. Training data generation for artificial intelligence-based sequencing

Also Published As

Publication number Publication date
CN115803816A (zh) 2023-03-14
WO2022212180A1 (fr) 2022-10-06
AU2022248999A1 (en) 2023-02-02
EP4315343A1 (fr) 2024-02-07

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