CA3182325A1 - Cereblon binding compounds, compositions thereof, and methods of treatment therewith - Google Patents

Cereblon binding compounds, compositions thereof, and methods of treatment therewith

Info

Publication number
CA3182325A1
CA3182325A1 CA3182325A CA3182325A CA3182325A1 CA 3182325 A1 CA3182325 A1 CA 3182325A1 CA 3182325 A CA3182325 A CA 3182325A CA 3182325 A CA3182325 A CA 3182325A CA 3182325 A1 CA3182325 A1 CA 3182325A1
Authority
CA
Canada
Prior art keywords
mmol
trans
trifluoromethyl
equiv
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3182325A
Other languages
English (en)
French (fr)
Inventor
Matthew D. Alexander
Matthew D. Correa
Deepak DALVIE
Virginia Heather Sharron Grant
Joshua Hansen
Iii Roy L. Harris
Evan J. Horn
Dehua Huang
Christopher Mayne
Stephen Norris
Veronique Plantevin-Krenitsky
John J. Sapienza
Lida Tehrani
Brandon W. Whitefield
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celgene Corp
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of CA3182325A1 publication Critical patent/CA3182325A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
CA3182325A 2020-06-24 2021-06-23 Cereblon binding compounds, compositions thereof, and methods of treatment therewith Pending CA3182325A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063043555P 2020-06-24 2020-06-24
US63/043,555 2020-06-24
PCT/US2021/038618 WO2021262810A1 (en) 2020-06-24 2021-06-23 Cereblon binding compounds, compositions thereof, and methods of treatment therewith

Publications (1)

Publication Number Publication Date
CA3182325A1 true CA3182325A1 (en) 2021-12-30

Family

ID=79032408

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3182325A Pending CA3182325A1 (en) 2020-06-24 2021-06-23 Cereblon binding compounds, compositions thereof, and methods of treatment therewith

Country Status (17)

Country Link
US (3) US11634407B2 (https=)
EP (1) EP4171566A4 (https=)
JP (2) JP7781792B2 (https=)
KR (1) KR20230027066A (https=)
CN (2) CN120441548A (https=)
AR (1) AR122723A1 (https=)
AU (1) AU2021296833A1 (https=)
BR (1) BR112022025933A2 (https=)
CA (1) CA3182325A1 (https=)
CL (1) CL2022003719A1 (https=)
CO (1) CO2022018653A2 (https=)
IL (1) IL299256A (https=)
MX (1) MX2022015757A (https=)
PE (1) PE20231746A1 (https=)
SA (1) SA522441857B1 (https=)
TW (1) TW202216680A (https=)
WO (1) WO2021262810A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020405129A1 (en) 2019-12-19 2022-06-23 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of androgen receptor
CR20220630A (es) 2020-05-09 2023-01-23 Arvinas Operations Inc Métodos para fabricar un compuesto bifuncional, formas ultrapuras del compuesto bifuncional y formas de dosificación que comprenden el mismo
JP7778095B2 (ja) 2020-06-24 2025-12-01 セルジーン コーポレーション セレブロン結合化合物、その組成物及びそれによる治療方法
KR20230027214A (ko) 2020-06-24 2023-02-27 셀진 코포레이션 세레블론 결합 화합물, 이의 조성물, 및 이에 의한 치료 방법
KR20230027066A (ko) 2020-06-24 2023-02-27 셀진 코포레이션 세레블론 결합 화합물, 이의 조성물, 및 이에 의한 치료 방법
CN117561249A (zh) * 2021-06-25 2024-02-13 细胞基因公司 Cereblon结合化合物、其组合物及其用于治疗的方法
EP4584259A1 (en) 2022-09-09 2025-07-16 Innovo Therapeutics, Inc. Ck1alpha and dual ck1alpha / gspt1 degrading compounds
WO2025063888A1 (en) 2023-09-19 2025-03-27 Kancure Pte. Ltd. Survivin-targeted compounds
TW202535392A (zh) 2023-12-08 2025-09-16 美商亞文納營運公司 使用雄性素受體降解劑治療脊髓延髓性肌肉萎縮
WO2025179161A1 (en) 2024-02-21 2025-08-28 Innovo Therapeutics, Inc. Protein degrading compounds

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101032483B (zh) * 2006-03-09 2011-05-04 陈德桂 调节雄激素受体活性的乙内酰脲衍生物及其应用
JP6817962B2 (ja) * 2015-01-20 2021-01-20 アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． ターゲティングされたアンドロゲン受容体分解のための化合物および方法
CN109641874A (zh) * 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
CN110023297A (zh) * 2016-07-08 2019-07-16 詹森药业有限公司 作为雄性激素受体拮抗剂的取代的乙内酰脲和硫代己内酰脲衍生物
CN110769822A (zh) * 2017-06-20 2020-02-07 C4医药公司 用于蛋白降解的n/o-连接的降解决定子和降解决定子体
WO2020051260A1 (en) * 2018-09-05 2020-03-12 University Of Tennessee Research Foundation Selective androgen receptor degrader (sard) ligands and methods of use thereof
CN113473987B (zh) 2018-12-19 2024-09-03 细胞基因公司 被取代的3-((3-氨基苯基)氨基)哌啶-2,6-二酮化合物、其组合物和使用其的治疗方法
CN113453681B (zh) 2018-12-19 2024-10-11 细胞基因公司 经取代的3-((3-氨基苯基)氨基)哌啶-2，6-二酮化合物、其组合物及使用它们的治疗方法
JP7778095B2 (ja) 2020-06-24 2025-12-01 セルジーン コーポレーション セレブロン結合化合物、その組成物及びそれによる治療方法
KR20230027214A (ko) 2020-06-24 2023-02-27 셀진 코포레이션 세레블론 결합 화합물, 이의 조성물, 및 이에 의한 치료 방법
KR20230027066A (ko) 2020-06-24 2023-02-27 셀진 코포레이션 세레블론 결합 화합물, 이의 조성물, 및 이에 의한 치료 방법

Also Published As

Publication number Publication date
AR122723A1 (es) 2022-09-28
US20250188056A1 (en) 2025-06-12
EP4171566A4 (en) 2024-07-24
SA522441857B1 (ar) 2024-07-21
PE20231746A1 (es) 2023-11-06
US20210403454A1 (en) 2021-12-30
US20230242509A1 (en) 2023-08-03
IL299256A (en) 2023-02-01
US11634407B2 (en) 2023-04-25
JP7781792B2 (ja) 2025-12-08
JP2026035702A (ja) 2026-03-04
WO2021262810A1 (en) 2021-12-30
CN115835866B (zh) 2025-05-02
KR20230027066A (ko) 2023-02-27
AU2021296833A1 (en) 2023-01-19
CL2022003719A1 (es) 2023-05-12
CN120441548A (zh) 2025-08-08
JP2023533203A (ja) 2023-08-02
MX2022015757A (es) 2023-01-19
US12103920B2 (en) 2024-10-01
EP4171566A1 (en) 2023-05-03
CN115835866A (zh) 2023-03-21
TW202216680A (zh) 2022-05-01
CO2022018653A2 (es) 2023-03-27
BR112022025933A2 (pt) 2023-01-10

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