CA3174222A1 - Methods for synthesis of chk1 inhibitors - Google Patents

Methods for synthesis of chk1 inhibitors Download PDF

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Publication number
CA3174222A1
CA3174222A1 CA3174222A CA3174222A CA3174222A1 CA 3174222 A1 CA3174222 A1 CA 3174222A1 CA 3174222 A CA3174222 A CA 3174222A CA 3174222 A CA3174222 A CA 3174222A CA 3174222 A1 CA3174222 A1 CA 3174222A1
Authority
CA
Canada
Prior art keywords
compound
mol
pharmaceutical composition
impurities
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3174222A
Other languages
English (en)
French (fr)
Inventor
Michael Schwaebe
Thorsten Rosner
Dalian Zhao
Ross Miller
Rich DULINA
Michael Humora
Stephen E. GOTTSCHLING
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sierra Oncology Inc
Original Assignee
Sierra Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sierra Oncology Inc filed Critical Sierra Oncology Inc
Publication of CA3174222A1 publication Critical patent/CA3174222A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/265—Citric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA3174222A 2020-04-07 2021-04-06 Methods for synthesis of chk1 inhibitors Pending CA3174222A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063006305P 2020-04-07 2020-04-07
US63/006,305 2020-04-07
PCT/US2021/025977 WO2021207210A1 (en) 2020-04-07 2021-04-06 Methods for synthesis of chk1 inhibitors

Publications (1)

Publication Number Publication Date
CA3174222A1 true CA3174222A1 (en) 2021-10-14

Family

ID=78024095

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3174222A Pending CA3174222A1 (en) 2020-04-07 2021-04-06 Methods for synthesis of chk1 inhibitors

Country Status (8)

Country Link
US (1) US12606550B2 (https=)
EP (1) EP4132922A4 (https=)
JP (1) JP2023523165A (https=)
CN (2) CN115443271A (https=)
BR (1) BR112022020278A2 (https=)
CA (1) CA3174222A1 (https=)
TW (1) TW202204348A (https=)
WO (1) WO2021207210A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202204348A (zh) 2020-04-07 2022-02-01 美商西爾拉癌症醫學公司 Ｃｈｋ１抑制劑之合成方法

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Also Published As

Publication number Publication date
CN115443271A (zh) 2022-12-06
TW202204348A (zh) 2022-02-01
EP4132922A1 (en) 2023-02-15
WO2021207210A1 (en) 2021-10-14
CN120441567A (zh) 2025-08-08
US20230150994A1 (en) 2023-05-18
BR112022020278A2 (pt) 2022-12-06
JP2023523165A (ja) 2023-06-02
EP4132922A4 (en) 2024-07-03
US12606550B2 (en) 2026-04-21

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