CA3159320A1 - Systemes d'administration de particules - Google Patents
Systemes d'administration de particules Download PDFInfo
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- CA3159320A1 CA3159320A1 CA3159320A CA3159320A CA3159320A1 CA 3159320 A1 CA3159320 A1 CA 3159320A1 CA 3159320 A CA3159320 A CA 3159320A CA 3159320 A CA3159320 A CA 3159320A CA 3159320 A1 CA3159320 A1 CA 3159320A1
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Abstract
L'invention concerne des systèmes d'administration de particules (XDP) utiles pour l'administration de charges utiles de tout type. Dans certains modes de réalisation, un système de particules XDP ayant un tropisme pour des cellules cibles d'intérêt est utilisé pour administrer des polypeptides CRISPR/Cas (par exemple, des protéines CasX) et des acides nucléiques de guidage (gNA), pour la modification d'acides nucléiques dans des cellules cibles. L'invention concerne également des procédés de fabrication et d'utilisation d'un tel XDP pour modifier les acides nucléiques dans de telles cellules.
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962944982P | 2019-12-06 | 2019-12-06 | |
| US62/944,982 | 2019-12-06 | ||
| US202062968915P | 2020-01-31 | 2020-01-31 | |
| US62/968,915 | 2020-01-31 | ||
| US202062983460P | 2020-02-28 | 2020-02-28 | |
| US62/983,460 | 2020-02-28 | ||
| US202063035576P | 2020-06-05 | 2020-06-05 | |
| US63/035,576 | 2020-06-05 | ||
| US202063120864P | 2020-12-03 | 2020-12-03 | |
| US63/120,864 | 2020-12-03 | ||
| PCT/US2020/063488 WO2021113772A1 (fr) | 2019-12-06 | 2020-12-04 | Systèmes d'administration de particules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3159320A1 true CA3159320A1 (fr) | 2021-06-10 |
Family
ID=74046189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3159320A Pending CA3159320A1 (fr) | 2019-12-06 | 2020-12-04 | Systemes d'administration de particules |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP4069716A1 (fr) |
| JP (1) | JP2023504536A (fr) |
| KR (1) | KR20220113442A (fr) |
| CN (1) | CN115175921A (fr) |
| AU (1) | AU2020398658A1 (fr) |
| CA (1) | CA3159320A1 (fr) |
| IL (1) | IL293591A (fr) |
| WO (1) | WO2021113772A1 (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020247882A1 (fr) | 2019-06-07 | 2020-12-10 | Scribe Therapeutics Inc. | Systèmes casx modifiés |
| GB2616584A (en) * | 2020-12-03 | 2023-09-13 | Scribe Therapeutics Inc | Engineered class 2 type V CRISPR systems |
| WO2022120089A1 (fr) | 2020-12-03 | 2022-06-09 | Scribe Therapeutics Inc. | Compositions et procédés pour le ciblage de ptbp1 |
| WO2022261149A2 (fr) | 2021-06-09 | 2022-12-15 | Scribe Therapeutics Inc. | Systèmes d'administration de particules |
| IL311610A (en) | 2021-09-21 | 2024-05-01 | Scribe Therapeutics Inc | Engineered CASX suppressor systems |
| WO2023212396A1 (fr) * | 2022-04-29 | 2023-11-02 | The Board Of Trustees Of The Leland Stanford Junior University | Vecteurs lentiviraux de grande capacité |
| WO2023235818A2 (fr) | 2022-06-02 | 2023-12-07 | Scribe Therapeutics Inc. | Systèmes crispr de type v, classe 2, modifiés |
| WO2023235888A2 (fr) | 2022-06-03 | 2023-12-07 | Scribe Therapeutics Inc. | Compositions et procédés d'appauvrissement de cpg |
| EP4314267A1 (fr) | 2022-06-07 | 2024-02-07 | Scribe Therapeutics Inc. | Compositions et procédés pour le ciblage de pcsk9 |
| WO2023240027A1 (fr) | 2022-06-07 | 2023-12-14 | Scribe Therapeutics Inc. | Systèmes d'administration de particules |
| WO2023240074A1 (fr) | 2022-06-07 | 2023-12-14 | Scribe Therapeutics Inc. | Compositions et procédés pour le ciblage de pcsk9 |
| WO2023240157A2 (fr) | 2022-06-08 | 2023-12-14 | Scribe Therapeutics Inc. | Compositions et méthodes pour le ciblage de la dmd |
| WO2023240162A1 (fr) | 2022-06-08 | 2023-12-14 | Scribe Therapeutics Inc. | Vecteurs aav pour l'édition de gènes |
| CN117344061B (zh) * | 2023-12-05 | 2024-02-27 | 云南省细胞质量检测评价中心有限公司 | 一种同时检测五种人源病毒ebv、hbv、hcv、hiv、hpv的方法、试剂盒、引物和探针及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE302854T1 (de) | 1993-01-26 | 2005-09-15 | Univ Pennsylvania | Zusammensetzungen und verfahren zur verabreichung von genetischem material |
| US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| US5962428A (en) | 1995-03-30 | 1999-10-05 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| WO2010075303A1 (fr) | 2008-12-23 | 2010-07-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Facteurs d'épissage avec un domaine de liaison à l'arn de protéine puf et domaine effecteur d'épissage et leurs utilisations |
| US9580714B2 (en) | 2010-11-24 | 2017-02-28 | The University Of Western Australia | Peptides for the specific binding of RNA targets |
| JP7059179B2 (ja) * | 2015-10-20 | 2022-04-25 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 遺伝子操作のための方法及び製品 |
| EP3523426A4 (fr) | 2016-09-30 | 2020-01-22 | The Regents of The University of California | Nouvelles enzymes de modification d'acides nucléiques guidées par arn et leurs méthodes d'utilisation |
| JP2020518275A (ja) * | 2017-05-03 | 2020-06-25 | バイオマリン ファーマシューティカル インコーポレイテッド | 造血幹細胞の形質導入のための改善されたレンチウイルス |
-
2020
- 2020-12-04 KR KR1020227022874A patent/KR20220113442A/ko unknown
- 2020-12-04 EP EP20829466.0A patent/EP4069716A1/fr active Pending
- 2020-12-04 JP JP2022533213A patent/JP2023504536A/ja active Pending
- 2020-12-04 AU AU2020398658A patent/AU2020398658A1/en active Pending
- 2020-12-04 WO PCT/US2020/063488 patent/WO2021113772A1/fr unknown
- 2020-12-04 CA CA3159320A patent/CA3159320A1/fr active Pending
- 2020-12-04 CN CN202080094851.0A patent/CN115175921A/zh active Pending
- 2020-12-04 IL IL293591A patent/IL293591A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023504536A (ja) | 2023-02-03 |
| EP4069716A1 (fr) | 2022-10-12 |
| AU2020398658A1 (en) | 2022-07-07 |
| IL293591A (en) | 2022-08-01 |
| CN115175921A (zh) | 2022-10-11 |
| WO2021113772A1 (fr) | 2021-06-10 |
| KR20220113442A (ko) | 2022-08-12 |
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