CA3157586C - Compositions and methods for polynucleotide sequencing - Google Patents

Compositions and methods for polynucleotide sequencing

Info

Publication number
CA3157586C
CA3157586C CA3157586A CA3157586A CA3157586C CA 3157586 C CA3157586 C CA 3157586C CA 3157586 A CA3157586 A CA 3157586A CA 3157586 A CA3157586 A CA 3157586A CA 3157586 C CA3157586 C CA 3157586C
Authority
CA
Canada
Prior art keywords
pore
helicase
polynucleotide
seq
target polynucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3157586A
Other languages
English (en)
French (fr)
Other versions
CA3157586A1 (en
Inventor
Eric STAVA
H. Gundlach Jens
G. Mandell Jeffrey
L. Gunderson Kevin
M. Derrington Ian
Hosein MOHIMANI
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Inc filed Critical Illumina Inc
Priority to CA3157586A priority Critical patent/CA3157586C/en
Publication of CA3157586A1 publication Critical patent/CA3157586A1/en
Application granted granted Critical
Publication of CA3157586C publication Critical patent/CA3157586C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Food Science & Technology (AREA)
  • Nanotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CA3157586A 2013-11-26 2014-11-26 Compositions and methods for polynucleotide sequencing Active CA3157586C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3157586A CA3157586C (en) 2013-11-26 2014-11-26 Compositions and methods for polynucleotide sequencing

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361909316P 2013-11-26 2013-11-26
US61/909,316 2013-11-26
CA3157586A CA3157586C (en) 2013-11-26 2014-11-26 Compositions and methods for polynucleotide sequencing
CA2926871A CA2926871C (en) 2013-11-26 2014-11-26 Compositions and methods for polynucleotide sequencing

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2926871A Division CA2926871C (en) 2013-11-26 2014-11-26 Compositions and methods for polynucleotide sequencing

Publications (2)

Publication Number Publication Date
CA3157586A1 CA3157586A1 (en) 2015-06-04
CA3157586C true CA3157586C (en) 2026-02-03

Family

ID=52424089

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3157586A Active CA3157586C (en) 2013-11-26 2014-11-26 Compositions and methods for polynucleotide sequencing
CA2926871A Active CA2926871C (en) 2013-11-26 2014-11-26 Compositions and methods for polynucleotide sequencing

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2926871A Active CA2926871C (en) 2013-11-26 2014-11-26 Compositions and methods for polynucleotide sequencing

Country Status (12)

Country Link
US (5) US9689033B2 (enExample)
EP (3) EP3074534B1 (enExample)
JP (4) JP6800749B2 (enExample)
CN (2) CN105934522B (enExample)
AU (3) AU2014354726B2 (enExample)
CA (2) CA3157586C (enExample)
DK (2) DK3556869T3 (enExample)
ES (2) ES2735015T3 (enExample)
FI (1) FI3556869T3 (enExample)
LT (1) LT3074534T (enExample)
SI (1) SI3074534T1 (enExample)
WO (2) WO2015081211A2 (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0905140D0 (en) 2009-03-25 2009-05-06 Isis Innovation Method
EP3663412B1 (en) * 2011-09-23 2022-03-09 Oxford Nanopore Technologies PLC Analysis of a polymer comprising polymer units by means of translocation through a nanopore
EP3736339B1 (en) 2012-02-16 2022-07-27 Oxford Nanopore Technologies plc Analysis of measurements of a polymer
WO2013153359A1 (en) 2012-04-10 2013-10-17 Oxford Nanopore Technologies Limited Mutant lysenin pores
GB201222928D0 (en) 2012-12-19 2013-01-30 Oxford Nanopore Tech Ltd Analysis of a polynucleotide
GB201313477D0 (en) 2013-07-29 2013-09-11 Univ Leuven Kath Nanopore biosensors for detection of proteins and nucleic acids
ES2735015T3 (es) * 2013-11-26 2019-12-13 Illumina Inc Composiciones y métodos para secuenciar polinucleótidos
EP3097210B2 (en) 2014-01-22 2022-04-20 Oxford Nanopore Technologies Limited Method for attaching one or more polynucleotide binding proteins to a target polynucleotide
US10359395B2 (en) 2014-02-19 2019-07-23 University Of Washington Nanopore-based analysis of protein characteristics
US10443097B2 (en) 2014-05-02 2019-10-15 Oxford Nanopore Technologies Ltd. Method of improving the movement of a target polynucleotide with respect to a transmembrane pore
CN119899249A (zh) 2014-09-01 2025-04-29 弗拉芒区生物技术研究所 突变csgg孔
EP3971300B1 (en) 2014-10-16 2024-06-05 Oxford Nanopore Technologies plc Sorting of polymers
GB201502810D0 (en) 2015-02-19 2015-04-08 Oxford Nanopore Tech Ltd Method
WO2017027518A1 (en) * 2015-08-10 2017-02-16 Stratos Genomics, Inc. Single molecule nucleic acid sequencing with molecular sensor complexes
CA3002886A1 (en) * 2015-10-21 2017-04-27 F. Hoffmann-La Roche Ag Use of fluoropolymers as a hydrophobic layer to support lipid bilayer formation for nanopore based dna sequencing
KR102222191B1 (ko) 2016-03-02 2021-03-02 옥스포드 나노포어 테크놀로지즈 리미티드 돌연변이체 기공
CN118272512A (zh) 2016-04-06 2024-07-02 牛津纳米孔科技公开有限公司 突变体孔
WO2017180141A1 (en) 2016-04-14 2017-10-19 Lockheed Martin Corporation Selective interfacial mitigation of graphene defects
US10317392B2 (en) * 2016-06-23 2019-06-11 Roche Sequencing Solutions, Inc. Formation and calibration of nanopore sequencing cells
US10648027B2 (en) 2016-08-08 2020-05-12 Roche Sequencing Solutions, Inc. Basecalling for stochastic sequencing processes
PL3529380T3 (pl) 2016-10-19 2022-10-24 Illumina, Inc. Sposoby chemicznej ligacji kwasów nukleinowych
GB201707122D0 (en) 2017-05-04 2017-06-21 Oxford Nanopore Tech Ltd Pore
EP3645552B1 (en) 2017-06-30 2023-06-28 Vib Vzw Novel protein pores
EP3682020B1 (en) * 2017-09-15 2025-09-03 Illumina, Inc. Sequence-detection system
WO2019055856A1 (en) * 2017-09-15 2019-03-21 Illumina, Inc. ACCORDING AND CALIBRATION CHARACTERISTICS OF A SEQUENCE DETECTION SYSTEM
US10310959B2 (en) 2017-11-07 2019-06-04 Bank Of America Corporation Pre-deployment validation system using intelligent databases
WO2019243421A1 (en) * 2018-06-21 2019-12-26 F. Hoffmann-La Roche Ag Tunneling junctions for sequencing
EP3814529A1 (en) * 2018-06-26 2021-05-05 Electronic Biosciences Inc. Controlled nanopore translocation utilizing extremophilic replication proteins
MY204234A (en) 2018-08-27 2024-08-16 Regeneron Pharma Use of raman spectroscopy in downstream purification
JP2020031557A (ja) * 2018-08-28 2020-03-05 株式会社日立ハイテクノロジーズ 生体分子分析装置
WO2020084705A1 (ja) * 2018-10-24 2020-04-30 株式会社日立ハイテク 生体ポリマ分析デバイス及びそれを用いた分析装置、並びに分析方法
GB201907244D0 (en) * 2019-05-22 2019-07-03 Oxford Nanopore Tech Ltd Method
IL291787A (en) 2019-09-29 2022-07-01 Qitan Tech Ltd Beijing mmup monomer variant and its application
IL293024B1 (en) * 2019-11-19 2026-07-01 Univ Groningen Artificial insemination, methods and uses
NL2024579B1 (en) * 2019-12-24 2021-09-06 Univ Delft Tech Protein and peptide fingerprinting and sequencing by nanopore translocation of peptide-oligonucleotide complexes
CN114807317A (zh) * 2021-01-22 2022-07-29 上海羿鸣生物科技有限公司 一种优化的dna线性扩增方法及试剂盒
GB202107192D0 (en) * 2021-05-19 2021-06-30 Oxford Nanopore Tech Ltd Method
CN113322180B (zh) * 2021-05-31 2022-07-15 中国科学院物理研究所 基于纳米孔测序的力谱分析方法和分析装置
WO2023049682A1 (en) 2021-09-22 2023-03-30 Illumina, Inc. Sequencing polynucleotides using nanopores
US20230298693A1 (en) * 2022-02-28 2023-09-21 Rajant Health Incorporated Alignment-free variant calling
CN120435657A (zh) 2022-10-28 2025-08-05 格罗宁根大学 蛋白质的基于纳米孔的分析
WO2024220969A2 (en) * 2023-04-21 2024-10-24 Arizona Board Of Regents On Behalf Of Arizona State University Novel transmembrane sensors and method of characterization for lysis-free detection of intracellular targets
WO2026073207A1 (en) 2024-09-30 2026-04-02 Illumina, Inc. Affinity-binder-based assay compositions and methods
CN119639558B (zh) * 2024-12-13 2025-09-26 杭州海兰时生物科技有限责任公司 一种用于单细胞测序的液滴融合系统
WO2026143014A1 (en) 2024-12-23 2026-07-02 Illumina, Inc. Affinity-binder-based assay compositions and methods for spatial proteomics

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469863A (en) 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
US5602240A (en) 1990-07-27 1997-02-11 Ciba Geigy Ag. Backbone modified oligonucleotide analogs
US5386023A (en) 1990-07-27 1995-01-31 Isis Pharmaceuticals Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
US5644048A (en) 1992-01-10 1997-07-01 Isis Pharmaceuticals, Inc. Process for preparing phosphorothioate oligonucleotides
US5637684A (en) 1994-02-23 1997-06-10 Isis Pharmaceuticals, Inc. Phosphoramidate and phosphorothioamidate oligomeric compounds
US5508179A (en) 1994-03-18 1996-04-16 Bio-Rad Laboratories, Inc. Use of deoxyribose nicotinamide adenine dinucleotide to enhance the specificity of NAD+ -dependent ligation reactions
US5795782A (en) * 1995-03-17 1998-08-18 President & Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
EP1192103A1 (en) 1999-06-22 2002-04-03 President And Fellows of Harvard College Control of solid state dimensional features
US6913884B2 (en) 2001-08-16 2005-07-05 Illumina, Inc. Compositions and methods for repetitive use of genomic DNA
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
JP2003521252A (ja) 2000-02-07 2003-07-15 イルミナ インコーポレイテッド ユニバーサルプライミングを用いる核酸検出方法
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
GB0505971D0 (en) 2005-03-23 2005-04-27 Isis Innovation Delivery of molecules to a lipid bilayer
EP2122344B8 (en) 2007-02-20 2019-08-21 Oxford Nanopore Technologies Limited Lipid bilayer sensor system
US20110229877A1 (en) * 2008-07-07 2011-09-22 Oxford Nanopore Technologies Limited Enzyme-pore constructs
DE202009019021U1 (de) 2008-09-22 2015-09-24 University Of Washington Msp-nanoporen
GB0905140D0 (en) * 2009-03-25 2009-05-06 Isis Innovation Method
EP2614156B1 (en) 2010-09-07 2018-08-01 The Regents of The University of California Control of dna movement in a nanopore at one nucleotide precision by a processive enzyme
WO2013016486A1 (en) 2011-07-27 2013-01-31 The Board Of Trustees Of The University Of Illinois Nanopore sensors for biomolecular characterization
CN104039979B (zh) * 2011-10-21 2016-08-24 牛津纳米孔技术公司 使用孔和Hel308解旋酶表征目标多核苷酸的酶方法
CA2861808C (en) 2011-12-29 2021-02-23 Oxford Nanopore Technologies Limited Enzyme method
EP2798083B1 (en) 2011-12-29 2017-08-09 Oxford Nanopore Technologies Limited Method for characterising a polynucelotide by using a xpd helicase
JP5809572B2 (ja) 2012-01-30 2015-11-11 ルネサスエレクトロニクス株式会社 半導体装置
WO2013153359A1 (en) 2012-04-10 2013-10-17 Oxford Nanopore Technologies Limited Mutant lysenin pores
GB2559073A (en) * 2012-06-08 2018-07-25 Pacific Biosciences California Inc Modified base detection with nanopore sequencing
AU2013291763B2 (en) * 2012-07-19 2019-06-20 Oxford Nanopore Technologies Limited Modified helicases
ES2735015T3 (es) * 2013-11-26 2019-12-13 Illumina Inc Composiciones y métodos para secuenciar polinucleótidos

Also Published As

Publication number Publication date
JP2023116553A (ja) 2023-08-22
JP2021040646A (ja) 2021-03-18
EP3556869A1 (en) 2019-10-23
JP2017503473A (ja) 2017-02-02
JP2025072503A (ja) 2025-05-09
US11879155B2 (en) 2024-01-23
CA2926871C (en) 2022-08-16
WO2015081211A2 (en) 2015-06-04
AU2020202489A1 (en) 2020-05-07
ES2958715T3 (es) 2024-02-13
AU2022231786A1 (en) 2022-10-13
EP3074534A1 (en) 2016-10-05
US20210355534A1 (en) 2021-11-18
CA2926871A1 (en) 2015-06-04
AU2014354726A1 (en) 2016-06-02
US20150152495A1 (en) 2015-06-04
US20170268055A1 (en) 2017-09-21
US20200024657A1 (en) 2020-01-23
DK3556869T3 (da) 2023-10-02
US20240167085A1 (en) 2024-05-23
EP4282983A2 (en) 2023-11-29
EP3556869B1 (en) 2023-08-02
WO2015081178A1 (en) 2015-06-04
AU2022231786B2 (en) 2025-04-17
CA3157586A1 (en) 2015-06-04
ES2735015T3 (es) 2019-12-13
EP3074534B1 (en) 2019-05-01
CN113528632A (zh) 2021-10-22
US9689033B2 (en) 2017-06-27
JP6800749B2 (ja) 2020-12-23
US11041196B2 (en) 2021-06-22
AU2020202489B2 (en) 2022-06-23
CN105934522A (zh) 2016-09-07
EP4282983A3 (en) 2024-02-28
US10364462B2 (en) 2019-07-30
CN105934522B (zh) 2021-07-20
FI3556869T3 (fi) 2023-09-28
WO2015081211A3 (en) 2015-08-06
JP7349972B2 (ja) 2023-09-25
SI3074534T1 (sl) 2019-08-30
AU2014354726B2 (en) 2020-03-12
DK3074534T3 (da) 2019-07-29
LT3074534T (lt) 2019-08-26

Similar Documents

Publication Publication Date Title
AU2022231786B2 (en) Compositions and methods for polynucleotide sequencing
US12503729B2 (en) Enzyme method
US10697006B2 (en) Hairpin-mediated amplification method
HK40018114B (en) Compositions and methods for polynucleotide sequencing
HK40018114A (en) Compositions and methods for polynucleotide sequencing
WO2026093331A1 (en) Hairpin adapter constructs and primers to generate next-generation sequencing library molecules
WO2026006622A2 (en) Sequencing full-complement polynucleotides using nanopores
WO2026099278A1 (en) Normalizing and pooling of pcr-free sequencing libraries
CN119325514A (zh) 调节成簇动力学的方法
CN119137284A (zh) 用于核酸扩增的嗜热组合物

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20220427

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 10TH ANNIV.) - STANDARD

Year of fee payment: 10

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20241115

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20241115

D22 Grant of ip right intended

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D22-D128 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: NOTICE OF ALLOWANCE IS ISSUED

Effective date: 20250530

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D22-D128 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: ALLOWANCE REQUIREMENTS DETERMINED COMPLIANT

Effective date: 20250530

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20250530

D00 Search and/or examination requested or commenced

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D00-D164 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: RESPONSE TO NOTICE OF ALLOWANCE

Effective date: 20250923

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 11TH ANNIV.) - STANDARD

Year of fee payment: 11

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20251104

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20251104

D22 Grant of ip right intended

Free format text: ST27 STATUS EVENT CODE: A-2-4-D10-D22-D143 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: PRE-GRANT

Effective date: 20251215

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20251215

Q17 Modified document published

Free format text: ST27 STATUS EVENT CODE: A-4-4-Q10-Q17-Q103 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: DOCUMENT PUBLISHED

Effective date: 20260128

F11 Ip right granted following substantive examination

Free format text: ST27 STATUS EVENT CODE: A-4-4-F10-F11-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: GRANT BY ISSUANCE

Effective date: 20260203