CA3154287A1 - Compositions et procedes de reprogrammation de tcr a l'aide de proteines de fusion - Google Patents
Compositions et procedes de reprogrammation de tcr a l'aide de proteines de fusion Download PDFInfo
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- CA3154287A1 CA3154287A1 CA3154287A CA3154287A CA3154287A1 CA 3154287 A1 CA3154287 A1 CA 3154287A1 CA 3154287 A CA3154287 A CA 3154287A CA 3154287 A CA3154287 A CA 3154287A CA 3154287 A1 CA3154287 A1 CA 3154287A1
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- C07K2319/00—Fusion polypeptide
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Abstract
L'invention concerne des acides nucléiques recombinés codant pour des protéines de fusion (TFP) de récepteurs de lymphocytes T (TCR) et un domaine constant de TCR, des lymphocytes T modifiés exprimant les molécules codées, et leurs méthodes d'utilisation pour le traitement de maladies, dont le cancer.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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US201962899563P | 2019-09-12 | 2019-09-12 | |
US62/899,563 | 2019-09-12 | ||
US202062971682P | 2020-02-07 | 2020-02-07 | |
US62/971,682 | 2020-02-07 | ||
PCT/US2020/050503 WO2021050948A1 (fr) | 2019-09-12 | 2020-09-11 | Compositions et procédés de reprogrammation de tcr à l'aide de protéines de fusion |
Publications (1)
Publication Number | Publication Date |
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CA3154287A1 true CA3154287A1 (fr) | 2021-03-18 |
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CA3154287A Pending CA3154287A1 (fr) | 2019-09-12 | 2020-09-11 | Compositions et procedes de reprogrammation de tcr a l'aide de proteines de fusion |
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EP (1) | EP4028033A4 (fr) |
JP (1) | JP2022548866A (fr) |
KR (1) | KR20220078607A (fr) |
CN (1) | CN114828862A (fr) |
AU (1) | AU2020344628A1 (fr) |
BR (1) | BR112022004458A2 (fr) |
CA (1) | CA3154287A1 (fr) |
IL (1) | IL291236A (fr) |
MX (1) | MX2022002984A (fr) |
WO (1) | WO2021050948A1 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023091420A2 (fr) * | 2021-11-16 | 2023-05-25 | TCR2 Therapeutics Inc. | Compositions et méthodes pour modification de lymphocytes t |
WO2023133296A2 (fr) * | 2022-01-07 | 2023-07-13 | Sorrento Therapeutics, Inc. | Récepteurs de lymphocytes t gamma delta ciblant pd-l1 modifiés |
WO2024039576A2 (fr) * | 2022-08-19 | 2024-02-22 | Memorial Sloan-Kettering Cancer Center | Récepteurs de lymphocytes t ciblant des mutations ras et utilisations associées |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9181527B2 (en) * | 2009-10-29 | 2015-11-10 | The Trustees Of Dartmouth College | T cell receptor-deficient T cell compositions |
DK3424947T3 (da) * | 2011-10-28 | 2021-02-22 | Regeneron Pharma | Genmodificerede t-celle-receptor-mus |
EP3842450A1 (fr) * | 2015-10-23 | 2021-06-30 | Eureka Therapeutics, Inc. | Constructions chimériques d'anticorps/récepteurs des lymphocytes t et leurs utilisations |
GB201604494D0 (en) * | 2016-03-16 | 2016-04-27 | Immatics Biotechnologies Gmbh | Transfected T-Cells and T-Cell receptors for use in immunotherapy against cancers |
PT3445787T (pt) * | 2016-10-07 | 2021-03-15 | Tcr2 Therapeutics Inc | Composições e métodos para reprogramação de recetores de célula t com o uso de proteínas de fusão |
CN110177803A (zh) * | 2016-11-22 | 2019-08-27 | T细胞受体治疗公司 | 用于使用融合蛋白进行tcr重新编程的组合物和方法 |
JP2020513754A (ja) * | 2016-12-21 | 2020-05-21 | ティーシーアール2 セラピューティクス インク. | がん治療用に操作されたt細胞 |
WO2018232020A1 (fr) * | 2017-06-13 | 2018-12-20 | TCR2 Therapeutics Inc. | Compositions et méthodes de reprogrammation de tcr au moyen de protéines de fusion |
US11738047B2 (en) * | 2017-12-12 | 2023-08-29 | The Trustees Of The University Of Pennsylvania | Genetically modified immune cells targeting NY-ESO-1 and methods of use thereof |
WO2019133443A1 (fr) * | 2017-12-28 | 2019-07-04 | Janux Therapeutics, Inc. | Récepteurs de lymphocytes t modifiés |
AU2019231792A1 (en) * | 2018-03-09 | 2020-10-22 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
-
2020
- 2020-09-11 WO PCT/US2020/050503 patent/WO2021050948A1/fr unknown
- 2020-09-11 CN CN202080079086.5A patent/CN114828862A/zh active Pending
- 2020-09-11 MX MX2022002984A patent/MX2022002984A/es unknown
- 2020-09-11 CA CA3154287A patent/CA3154287A1/fr active Pending
- 2020-09-11 AU AU2020344628A patent/AU2020344628A1/en active Pending
- 2020-09-11 KR KR1020227012166A patent/KR20220078607A/ko unknown
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- 2020-09-11 EP EP20862242.3A patent/EP4028033A4/fr active Pending
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2022
- 2022-03-09 IL IL291236A patent/IL291236A/en unknown
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Publication number | Publication date |
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WO2021050948A1 (fr) | 2021-03-18 |
EP4028033A1 (fr) | 2022-07-20 |
KR20220078607A (ko) | 2022-06-10 |
IL291236A (en) | 2022-05-01 |
JP2022548866A (ja) | 2022-11-22 |
EP4028033A4 (fr) | 2023-10-04 |
AU2020344628A1 (en) | 2022-04-07 |
BR112022004458A2 (pt) | 2022-05-31 |
MX2022002984A (es) | 2022-06-16 |
CN114828862A (zh) | 2022-07-29 |
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