CA3150508A1 - Azole-fused pyridazin-3(2h)-one derivatives - Google Patents

Azole-fused pyridazin-3(2h)-one derivatives Download PDF

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Publication number
CA3150508A1
CA3150508A1 CA3150508A CA3150508A CA3150508A1 CA 3150508 A1 CA3150508 A1 CA 3150508A1 CA 3150508 A CA3150508 A CA 3150508A CA 3150508 A CA3150508 A CA 3150508A CA 3150508 A1 CA3150508 A1 CA 3150508A1
Authority
CA
Canada
Prior art keywords
oxo
pyrazolo
dihydro
methy1
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3150508A
Other languages
English (en)
French (fr)
Inventor
Holger Monenschein
Sean Murphy
Scott Olsen
Natasha O'ROURKE
Holly REICHARD
Melinda DAVIS
Betty Lam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Publication of CA3150508A1 publication Critical patent/CA3150508A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA3150508A 2019-09-16 2020-09-15 Azole-fused pyridazin-3(2h)-one derivatives Pending CA3150508A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962901052P 2019-09-16 2019-09-16
US62/901,052 2019-09-16
PCT/US2020/050823 WO2021055326A1 (en) 2019-09-16 2020-09-15 Azole-fused pyridazin-3(2h)-one derivatives

Publications (1)

Publication Number Publication Date
CA3150508A1 true CA3150508A1 (en) 2021-03-25

Family

ID=72670806

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3150508A Pending CA3150508A1 (en) 2019-09-16 2020-09-15 Azole-fused pyridazin-3(2h)-one derivatives

Country Status (25)

Country Link
US (1) US12370192B2 (enExample)
EP (1) EP4031552B1 (enExample)
JP (1) JP7566888B2 (enExample)
KR (1) KR102924294B1 (enExample)
CN (1) CN114728975A (enExample)
AR (1) AR119971A1 (enExample)
AU (1) AU2020348675B2 (enExample)
BR (1) BR112022004819A2 (enExample)
CA (1) CA3150508A1 (enExample)
CO (1) CO2022004684A2 (enExample)
CR (1) CR20220160A (enExample)
DO (1) DOP2022000057A (enExample)
EC (1) ECSP22020159A (enExample)
ES (1) ES2997267T3 (enExample)
HR (1) HRP20250088T1 (enExample)
HU (1) HUE069908T2 (enExample)
IL (1) IL291181B2 (enExample)
JO (1) JOP20220063A1 (enExample)
MX (1) MX2022003177A (enExample)
PE (1) PE20221341A1 (enExample)
PH (1) PH12022550597A1 (enExample)
PL (1) PL4031552T3 (enExample)
RS (1) RS66463B1 (enExample)
TW (1) TWI873185B (enExample)
WO (1) WO2021055326A1 (enExample)

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PL4031552T3 (pl) 2019-09-16 2025-03-17 Takeda Pharmaceutical Company Limited Pochodne azolowo-skondensowanych pirydazyn-3(2h)-onów
JP7697974B2 (ja) 2020-05-08 2025-06-24 武田薬品工業株式会社 Ｇｐｒ１３９アゴニストの置換ベンゾトリアジノン代謝物
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CN114149371B (zh) * 2021-11-26 2023-08-22 首都医科大学 四取代吡唑类化合物及其应用
WO2023165262A1 (zh) * 2022-03-01 2023-09-07 上海科技大学 噻吩并含氮杂环类化合物、含其的药物组合物、其制备方法及其应用
US20250163065A1 (en) * 2022-03-01 2025-05-22 Shanghaitech University Pyrrolotriazinone compound, pharmaceutical composition comprising same, preparation method therefor, and use thereof
IT202200024948A1 (it) * 2022-12-05 2024-06-05 Angelini Pharma S P A Composti attivatori dei canali potassio KV7.2/KV7.3
CN116063179A (zh) * 2023-02-20 2023-05-05 南京杰运医药科技有限公司 一种4-甲氧基乙酰乙酸甲酯的合成方法
WO2025119351A1 (zh) * 2023-12-08 2025-06-12 深圳湾实验室 Gpr139激动剂
WO2025124544A1 (zh) * 2023-12-14 2025-06-19 华润医药研究院（深圳）有限公司 3,4-二氢-2H-苯并[b][1,4]二氧杂环庚烷类化合物及其制备方法和医药用途
WO2025162441A1 (zh) * 2024-02-02 2025-08-07 上海科技大学 稠杂环类化合物与其制备方法、药物组合物及应用

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Publication number Publication date
IL291181A (en) 2022-05-01
AU2020348675A1 (en) 2022-04-14
KR102924294B1 (ko) 2026-02-09
CR20220160A (es) 2022-06-16
JOP20220063A1 (ar) 2023-01-30
JP2022548602A (ja) 2022-11-21
US12370192B2 (en) 2025-07-29
EP4031552B1 (en) 2024-11-06
DOP2022000057A (es) 2022-06-30
MX2022003177A (es) 2022-04-06
IL291181B1 (en) 2025-05-01
EP4031552A1 (en) 2022-07-27
KR20220063228A (ko) 2022-05-17
US20230028114A1 (en) 2023-01-26
BR112022004819A2 (pt) 2022-06-07
HRP20250088T1 (hr) 2025-03-28
WO2021055326A1 (en) 2021-03-25
AU2020348675B2 (en) 2025-11-20
PL4031552T3 (pl) 2025-03-17
IL291181B2 (en) 2025-09-01
TWI873185B (zh) 2025-02-21
ES2997267T3 (en) 2025-02-14
CO2022004684A2 (es) 2022-07-08
ECSP22020159A (es) 2022-05-31
JP7566888B2 (ja) 2024-10-15
HUE069908T2 (hu) 2025-04-28
RS66463B1 (sr) 2025-02-28
TW202124386A (zh) 2021-07-01
EP4031552C0 (en) 2024-11-06
PH12022550597A1 (en) 2024-03-04
AR119971A1 (es) 2022-01-26
PE20221341A1 (es) 2022-09-13
CN114728975A (zh) 2022-07-08

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