CA3144476A1 - Biodegradable ultra-ph sensitive polymers - Google Patents

Biodegradable ultra-ph sensitive polymers Download PDF

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Publication number
CA3144476A1
CA3144476A1 CA3144476A CA3144476A CA3144476A1 CA 3144476 A1 CA3144476 A1 CA 3144476A1 CA 3144476 A CA3144476 A CA 3144476A CA 3144476 A CA3144476 A CA 3144476A CA 3144476 A1 CA3144476 A1 CA 3144476A1
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CA
Canada
Prior art keywords
substituted
a1ky1
polymer
alkyl
hydrogen
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Pending
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CA3144476A
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English (en)
French (fr)
Inventor
Jinming Gao
Xu Wang
Houliang TANG
Wei Li
Jonathan WILHELM
Baran SUMER
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University of Texas System
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University of Texas System
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Publication of CA3144476A1 publication Critical patent/CA3144476A1/en
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/3332—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing carboxamide group
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
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    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C08G65/3328—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof heterocyclic
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    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur
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    • C08G65/3342—Polymers modified by chemical after-treatment with organic compounds containing sulfur having sulfur bound to carbon and hydrogen
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    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C08G65/48—Polymers modified by chemical after-treatment
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    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
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  • Animal Behavior & Ethology (AREA)
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  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
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  • Gastroenterology & Hepatology (AREA)
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CA3144476A 2019-06-22 2020-06-22 Biodegradable ultra-ph sensitive polymers Pending CA3144476A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962865187P 2019-06-22 2019-06-22
US62/865,187 2019-06-22
PCT/US2020/038915 WO2020263733A1 (en) 2019-06-22 2020-06-22 Biodegradable ultra-ph sensitive polymers

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CA3144476A1 true CA3144476A1 (en) 2020-12-30

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US (1) US12365761B2 (enExample)
EP (1) EP3986467A4 (enExample)
JP (1) JP7676331B2 (enExample)
KR (1) KR20220024565A (enExample)
CN (1) CN114269387A (enExample)
AU (1) AU2020303968A1 (enExample)
BR (1) BR112021026025A2 (enExample)
CA (1) CA3144476A1 (enExample)
IL (1) IL289196A (enExample)
WO (1) WO2020263733A1 (enExample)

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AU2021340623A1 (en) * 2020-09-08 2023-04-13 The Board Of Regents Of The University Of Texas System Polyvalent STING activating compositions and uses thereof
WO2025059234A1 (en) * 2023-09-11 2025-03-20 The Board Of Regents Of The University Of Texas System Biodegradable stimulator of interferon genes (sting) activating nanoparticle compositions and uses thereof
WO2025059229A1 (en) * 2023-09-11 2025-03-20 The Board Of Regents Of The University Of Texas System Stimulator of interferon genes (sting)-cdc1 signature as a prognostic biomarker for cancer
WO2025129124A1 (en) * 2023-12-15 2025-06-19 The Board Of Regents Of The University Of Texas System Stimuli-responsive sting-activating polymer compositions and methods of use

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US7208314B2 (en) 2002-02-26 2007-04-24 Mirus Bio Corporation Compositions and methods for drug delivery using pH sensitive molecules
US7311901B2 (en) 2003-10-10 2007-12-25 Samyang Corporation Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery
US7179867B2 (en) * 2003-11-26 2007-02-20 Industrial Technology Research Institute Thermosensitive biodegradable copolymer
TWI388591B (zh) * 2008-03-28 2013-03-11 Ind Tech Res Inst 溫度敏感性材料
US8470891B2 (en) 2009-12-23 2013-06-25 International Business Machines Corporation Biodegradable block polymers for drug delivery, and methods related thereto
US8796405B2 (en) * 2012-01-18 2014-08-05 Wisconsin Alumni Research Foundation Degradable polycations derived from amino acid vinyl esters
AU2015269068A1 (en) 2014-06-06 2016-12-22 The Board Of Regents Of The University Of Texas System Library of pH responsive polymers and nanoprobes thereof
CA3016457A1 (en) 2016-03-02 2017-09-08 The Board Of Regents Of The University Of Texas System Sting activating nanovaccine for immunotherapy
US10376468B2 (en) * 2017-12-05 2019-08-13 International Business Machines Corporation Block copolymers and self-assembling nanoparticles formed therefrom

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