CA3136816A1 - Methods and uses of variant icos ligand (icosl) fusion proteins - Google Patents

Methods and uses of variant icos ligand (icosl) fusion proteins Download PDF

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Publication number
CA3136816A1
CA3136816A1 CA3136816A CA3136816A CA3136816A1 CA 3136816 A1 CA3136816 A1 CA 3136816A1 CA 3136816 A CA3136816 A CA 3136816A CA 3136816 A CA3136816 A CA 3136816A CA 3136816 A1 CA3136816 A1 CA 3136816A1
Authority
CA
Canada
Prior art keywords
icosl
variant
variant icosl
pharmaceutical composition
fusion protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3136816A
Other languages
English (en)
French (fr)
Inventor
Ryan SWANSON
Jing Yang
Stanford PENG
Jan HILLSON
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alpine Immune Sciences Inc
Original Assignee
Alpine Immune Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alpine Immune Sciences Inc filed Critical Alpine Immune Sciences Inc
Publication of CA3136816A1 publication Critical patent/CA3136816A1/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Cell Biology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA3136816A 2019-04-17 2020-04-16 Methods and uses of variant icos ligand (icosl) fusion proteins Pending CA3136816A1 (en)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201962835488P 2019-04-17 2019-04-17
US62/835,488 2019-04-17
US201962855830P 2019-05-31 2019-05-31
US62/855,830 2019-05-31
US201962931212P 2019-11-05 2019-11-05
US62/931,212 2019-11-05
US201962945071P 2019-12-06 2019-12-06
US62/945,071 2019-12-06
US202062962832P 2020-01-17 2020-01-17
US62/962,832 2020-01-17
US202062987854P 2020-03-10 2020-03-10
US62/987,854 2020-03-10
PCT/US2020/028601 WO2020214867A1 (en) 2019-04-17 2020-04-16 Methods and uses of variant icos ligand (icosl) fusion proteins

Publications (1)

Publication Number Publication Date
CA3136816A1 true CA3136816A1 (en) 2020-10-22

Family

ID=70554252

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3136816A Pending CA3136816A1 (en) 2019-04-17 2020-04-16 Methods and uses of variant icos ligand (icosl) fusion proteins

Country Status (12)

Country Link
US (1) US20220218785A1 (https=)
EP (2) EP4438054A3 (https=)
JP (2) JP2022529059A (https=)
KR (1) KR20220035032A (https=)
CN (1) CN114302736A (https=)
AU (1) AU2020257238A1 (https=)
BR (1) BR112021020447A2 (https=)
CA (1) CA3136816A1 (https=)
IL (1) IL287290A (https=)
MX (1) MX2021012607A (https=)
SG (1) SG11202111033VA (https=)
WO (1) WO2020214867A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2018012472A (es) 2016-04-15 2019-08-12 Alpine Immune Sciences Inc Proteinas inmunomoduladoras variantes de ligando icos y sus usos.
JP7749319B2 (ja) 2017-10-10 2025-10-06 アルパイン イミューン サイエンシズ インコーポレイテッド Ｃｔｌａ－４変異型免疫調節タンパク質およびそれらの使用
BR112020007542A2 (pt) 2017-10-18 2020-12-01 Alpine Immune Sciences, Inc. proteínas imunomoduladoras ligantes de icos variantes e composições e métodos relacionados
EP4146684A2 (en) 2020-05-08 2023-03-15 Alpine Immune Sciences, Inc. April and baff inhibitory immunomodulatory proteins with and without a t cell inhibitory protein and methods of use thereof
US20230408515A1 (en) * 2020-11-10 2023-12-21 Massachusetts Institute Of Technology Engineered protein for rapid, efficient capture of pathogen-specific antibodies
AU2022274964A1 (en) * 2021-05-11 2023-11-30 Shaochi Hsin Method for treatment of psoriasis
WO2023214705A1 (ko) * 2022-05-03 2023-11-09 고려대학교 산학협력단 Icos와의 결합력이 향상된 icos-l 변이체

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Also Published As

Publication number Publication date
EP3955953A1 (en) 2022-02-23
WO2020214867A1 (en) 2020-10-22
MX2021012607A (es) 2022-03-11
JP2022529059A (ja) 2022-06-16
JP2025090714A (ja) 2025-06-17
IL287290A (en) 2021-12-01
SG11202111033VA (en) 2021-11-29
AU2020257238A1 (en) 2021-12-02
CN114302736A (zh) 2022-04-08
BR112021020447A2 (pt) 2022-05-17
EP4438054A2 (en) 2024-10-02
KR20220035032A (ko) 2022-03-21
US20220218785A1 (en) 2022-07-14
EP4438054A3 (en) 2025-01-08

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