CA3136283A1 - Systems and methods for producing actinium-225 - Google Patents
Systems and methods for producing actinium-225 Download PDFInfo
- Publication number
- CA3136283A1 CA3136283A1 CA3136283A CA3136283A CA3136283A1 CA 3136283 A1 CA3136283 A1 CA 3136283A1 CA 3136283 A CA3136283 A CA 3136283A CA 3136283 A CA3136283 A CA 3136283A CA 3136283 A1 CA3136283 A1 CA 3136283A1
- Authority
- CA
- Canada
- Prior art keywords
- target
- radium
- neutrons
- actinium
- deuterons
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229940125666 actinium-225 Drugs 0.000 title claims abstract description 64
- QQINRWTZWGJFDB-YPZZEJLDSA-N actinium-225 Chemical compound [225Ac] QQINRWTZWGJFDB-YPZZEJLDSA-N 0.000 title claims abstract description 63
- 238000000034 method Methods 0.000 title claims abstract description 56
- HCWPIIXVSYCSAN-IGMARMGPSA-N Radium-226 Chemical compound [226Ra] HCWPIIXVSYCSAN-IGMARMGPSA-N 0.000 claims abstract description 64
- HCWPIIXVSYCSAN-BJUDXGSMSA-N radium-225 Chemical compound [225Ra] HCWPIIXVSYCSAN-BJUDXGSMSA-N 0.000 claims abstract description 29
- QQINRWTZWGJFDB-IGMARMGPSA-N actinium-227 Chemical compound [227Ac] QQINRWTZWGJFDB-IGMARMGPSA-N 0.000 claims description 18
- 229910052790 beryllium Inorganic materials 0.000 claims description 18
- ATBAMAFKBVZNFJ-UHFFFAOYSA-N beryllium atom Chemical compound [Be] ATBAMAFKBVZNFJ-UHFFFAOYSA-N 0.000 claims description 18
- 230000001678 irradiating effect Effects 0.000 claims description 18
- 238000006243 chemical reaction Methods 0.000 claims description 10
- 230000004907 flux Effects 0.000 claims description 6
- 230000005255 beta decay Effects 0.000 claims description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 3
- 229910052715 tantalum Inorganic materials 0.000 claims description 3
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims description 3
- 229910052725 zinc Inorganic materials 0.000 claims description 3
- 239000011701 zinc Substances 0.000 claims description 3
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 claims description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 2
- 229910052735 hafnium Inorganic materials 0.000 claims description 2
- VBJZVLUMGGDVMO-UHFFFAOYSA-N hafnium atom Chemical compound [Hf] VBJZVLUMGGDVMO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052750 molybdenum Inorganic materials 0.000 claims description 2
- 239000011733 molybdenum Substances 0.000 claims description 2
- 229910052698 phosphorus Inorganic materials 0.000 claims description 2
- 239000011574 phosphorus Substances 0.000 claims description 2
- 229910052719 titanium Inorganic materials 0.000 claims description 2
- 239000010936 titanium Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 14
- 238000010586 diagram Methods 0.000 description 10
- 229910052705 radium Inorganic materials 0.000 description 10
- HCWPIIXVSYCSAN-UHFFFAOYSA-N radium atom Chemical compound [Ra] HCWPIIXVSYCSAN-UHFFFAOYSA-N 0.000 description 10
- 238000000926 separation method Methods 0.000 description 9
- 229910052767 actinium Inorganic materials 0.000 description 7
- 239000002245 particle Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 5
- 206010028980 Neoplasm Diseases 0.000 description 4
- QQINRWTZWGJFDB-UHFFFAOYSA-N actinium atom Chemical compound [Ac] QQINRWTZWGJFDB-UHFFFAOYSA-N 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 239000000356 contaminant Substances 0.000 description 3
- 229910052805 deuterium Inorganic materials 0.000 description 3
- 230000004992 fission Effects 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 230000002285 radioactive effect Effects 0.000 description 3
- HCWPIIXVSYCSAN-OUBTZVSYSA-N radium-227 Chemical compound [227Ra] HCWPIIXVSYCSAN-OUBTZVSYSA-N 0.000 description 3
- 229910052770 Uranium Inorganic materials 0.000 description 2
- VWQVUPCCIRVNHF-OIOBTWANSA-N Yttrium-86 Chemical compound [86Y] VWQVUPCCIRVNHF-OIOBTWANSA-N 0.000 description 2
- 150000001257 actinium Chemical class 0.000 description 2
- QQINRWTZWGJFDB-OUBTZVSYSA-N actinium-228 Chemical compound [228Ac] QQINRWTZWGJFDB-OUBTZVSYSA-N 0.000 description 2
- 238000001311 chemical methods and process Methods 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000000295 emission spectrum Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000010884 ion-beam technique Methods 0.000 description 2
- 229910052741 iridium Inorganic materials 0.000 description 2
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 description 2
- GKOZUEZYRPOHIO-OUBTZVSYSA-N iridium-193 Chemical compound [193Ir] GKOZUEZYRPOHIO-OUBTZVSYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 210000002307 prostate Anatomy 0.000 description 2
- 229940121896 radiopharmaceutical Drugs 0.000 description 2
- 239000012217 radiopharmaceutical Substances 0.000 description 2
- 230000002799 radiopharmaceutical effect Effects 0.000 description 2
- HCWPIIXVSYCSAN-NJFSPNSNSA-N radium-228 Chemical compound [228Ra] HCWPIIXVSYCSAN-NJFSPNSNSA-N 0.000 description 2
- 229910052712 strontium Inorganic materials 0.000 description 2
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 2
- CIOAGBVUUVVLOB-YPZZEJLDSA-N strontium-86 Chemical compound [86Sr] CIOAGBVUUVVLOB-YPZZEJLDSA-N 0.000 description 2
- ZSLUVFAKFWKJRC-AHCXROLUSA-N thorium-228 Chemical compound [228Th] ZSLUVFAKFWKJRC-AHCXROLUSA-N 0.000 description 2
- JFALSRSLKYAFGM-UHFFFAOYSA-N uranium(0) Chemical compound [U] JFALSRSLKYAFGM-UHFFFAOYSA-N 0.000 description 2
- JFALSRSLKYAFGM-FTXFMUIASA-N uranium-233 Chemical compound [233U] JFALSRSLKYAFGM-FTXFMUIASA-N 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- -1 159 Chemical compound 0.000 description 1
- CNDWHJQEGZZDTQ-UHFFFAOYSA-N 2-(2-amino-2-oxoethoxy)acetamide Chemical compound NC(=O)COCC(N)=O CNDWHJQEGZZDTQ-UHFFFAOYSA-N 0.000 description 1
- BHOJWZDMZJQSLQ-UHFFFAOYSA-N 2-[2-(diethylamino)-2-oxoethoxy]-n,n-diethyloctanamide Chemical compound CCCCCCC(C(=O)N(CC)CC)OCC(=O)N(CC)CC BHOJWZDMZJQSLQ-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 230000005778 DNA damage Effects 0.000 description 1
- 231100000277 DNA damage Toxicity 0.000 description 1
- GYHNNYVSQQEPJS-YPZZEJLDSA-N Gallium-68 Chemical compound [68Ga] GYHNNYVSQQEPJS-YPZZEJLDSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- QUCRTRYCBXCFFH-UHFFFAOYSA-N [Ra].[O-][N+]([O-])=O Chemical compound [Ra].[O-][N+]([O-])=O QUCRTRYCBXCFFH-UHFFFAOYSA-N 0.000 description 1
- 229910052768 actinide Inorganic materials 0.000 description 1
- 150000001255 actinides Chemical class 0.000 description 1
- LBDSXVIYZYSRII-IGMARMGPSA-N alpha-particle Chemical compound [4He+2] LBDSXVIYZYSRII-IGMARMGPSA-N 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- RYXHOMYVWAEKHL-OUBTZVSYSA-N astatine-211 Chemical compound [211At] RYXHOMYVWAEKHL-OUBTZVSYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- JCXGWMGPZLAOME-RNFDNDRNSA-N bismuth-213 Chemical compound [213Bi] JCXGWMGPZLAOME-RNFDNDRNSA-N 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000003729 cation exchange resin Substances 0.000 description 1
- 235000019994 cava Nutrition 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- RYGMFSIKBFXOCR-IGMARMGPSA-N copper-64 Chemical compound [64Cu] RYGMFSIKBFXOCR-IGMARMGPSA-N 0.000 description 1
- RYGMFSIKBFXOCR-AKLPVKDBSA-N copper-67 Chemical compound [67Cu] RYGMFSIKBFXOCR-AKLPVKDBSA-N 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000005251 gamma ray Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 229910052747 lanthanoid Inorganic materials 0.000 description 1
- 150000002602 lanthanoids Chemical class 0.000 description 1
- WABPQHHGFIMREM-BKFZFHPZSA-N lead-212 Chemical compound [212Pb] WABPQHHGFIMREM-BKFZFHPZSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 208000010658 metastatic prostate carcinoma Diseases 0.000 description 1
- 238000002727 particle therapy Methods 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 238000011112 process operation Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000013077 target material Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- ZSLUVFAKFWKJRC-OIOBTWANSA-N thorium-229 Chemical compound [229Th] ZSLUVFAKFWKJRC-OIOBTWANSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- HCHKCACWOHOZIP-NJFSPNSNSA-N zinc-67 Chemical compound [67Zn] HCHKCACWOHOZIP-NJFSPNSNSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
- G21G1/06—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by neutron irradiation
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
- G21G1/10—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by bombardment with electrically charged particles
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H6/00—Targets for producing nuclear reactions
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
- G21G2001/0089—Actinium
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H13/00—Magnetic resonance accelerators; Cyclotrons
- H05H13/005—Cyclotrons
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Optics & Photonics (AREA)
- Plasma & Fusion (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Particle Accelerators (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962830687P | 2019-04-08 | 2019-04-08 | |
| US62/830,687 | 2019-04-08 | ||
| PCT/US2020/026837 WO2020210147A1 (en) | 2019-04-08 | 2020-04-06 | Systems and methods for producing actinium-225 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3136283A1 true CA3136283A1 (en) | 2020-10-15 |
Family
ID=72751481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3136283A Pending CA3136283A1 (en) | 2019-04-08 | 2020-04-06 | Systems and methods for producing actinium-225 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20220199276A1 (de) |
| EP (1) | EP3953949A4 (de) |
| JP (1) | JP2022526641A (de) |
| CN (1) | CN113939885A (de) |
| CA (1) | CA3136283A1 (de) |
| WO (1) | WO2020210147A1 (de) |
| ZA (1) | ZA202107594B (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3143452A1 (en) * | 2019-06-21 | 2020-12-24 | Nuclear Research And Consultancy Group | Method for producing actininium-225 from radium-226 |
| MX2024005739A (es) * | 2021-11-10 | 2024-08-20 | Westinghouse Electric Co Llc | Producción de ac-225 usando radiación gama. |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1807844B1 (de) * | 2004-09-28 | 2010-05-19 | Soreq Nuclear Research Center Israel Atomic Energy Commission | Verfahren und system zur herstellung von radioisotopen |
| US7460746B2 (en) * | 2005-01-13 | 2008-12-02 | Oewaves, Inc. | Tunable multi-loop opto-electronic oscillator with tunable RF or microwave filter based on optical filtering |
| US20070092051A1 (en) * | 2005-09-19 | 2007-04-26 | Adelman Stuart L | Method of producing radium-225 and decay products thereof |
| DE102006008023B4 (de) * | 2006-02-21 | 2008-05-29 | Actinium Pharmaceuticals, Inc. | Verfahren zum Reinigen von 225Ac aus bestrahlten 226Ra-Targets |
| RU2373589C1 (ru) * | 2008-09-23 | 2009-11-20 | Институт ядерных исследований РАН | Способ получения актиния-225 и изотопов радия и мишень для его осуществления (варианты) |
| JP5522564B2 (ja) * | 2009-02-24 | 2014-06-18 | 独立行政法人日本原子力研究開発機構 | 放射性同位元素の製造方法及び装置 |
| EP3192079A1 (de) * | 2014-09-11 | 2017-07-19 | Ibel S.A. | Vorrichtung und verfahren zur herstellung von radioisotopen |
| JP6713653B2 (ja) * | 2015-01-23 | 2020-06-24 | 国立大学法人 筑波大学 | 中性子発生用ターゲット、中性子発生装置、中性子発生用ターゲットの製造方法及び中性子発生方法 |
| US11798702B2 (en) * | 2018-09-06 | 2023-10-24 | Uchicago Argonne, Llc | System and method for collecting and isolating radiosotopes |
| JP7298874B2 (ja) * | 2019-04-02 | 2023-06-27 | 株式会社千代田テクノル | 放射性同位元素の製造方法、及び、放射性同位元素製造用の熱分離装置 |
-
2020
- 2020-04-06 CA CA3136283A patent/CA3136283A1/en active Pending
- 2020-04-06 CN CN202080042184.1A patent/CN113939885A/zh active Pending
- 2020-04-06 WO PCT/US2020/026837 patent/WO2020210147A1/en unknown
- 2020-04-06 EP EP20788528.6A patent/EP3953949A4/de active Pending
- 2020-04-06 US US17/602,056 patent/US20220199276A1/en active Pending
- 2020-04-06 JP JP2021559746A patent/JP2022526641A/ja active Pending
-
2021
- 2021-10-08 ZA ZA2021/07594A patent/ZA202107594B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3953949A1 (de) | 2022-02-16 |
| US20220199276A1 (en) | 2022-06-23 |
| CN113939885A (zh) | 2022-01-14 |
| JP2022526641A (ja) | 2022-05-25 |
| EP3953949A4 (de) | 2022-12-28 |
| ZA202107594B (en) | 2024-01-31 |
| WO2020210147A1 (en) | 2020-10-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20220920 |
|
| EEER | Examination request |
Effective date: 20220920 |
|
| EEER | Examination request |
Effective date: 20220920 |
|
| EEER | Examination request |
Effective date: 20220920 |
|
| EEER | Examination request |
Effective date: 20220920 |