CA3131654A1 - Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies - Google Patents

Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies Download PDF

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Publication number
CA3131654A1
CA3131654A1 CA3131654A CA3131654A CA3131654A1 CA 3131654 A1 CA3131654 A1 CA 3131654A1 CA 3131654 A CA3131654 A CA 3131654A CA 3131654 A CA3131654 A CA 3131654A CA 3131654 A1 CA3131654 A1 CA 3131654A1
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CA
Canada
Prior art keywords
egfr
cancer
met
seq
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3131654A
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English (en)
French (fr)
Inventor
Sheri MOORES
Smruthi VIJAYARAGHAVAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Biotech Inc
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Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of CA3131654A1 publication Critical patent/CA3131654A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3131654A 2019-02-26 2020-02-24 Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies Pending CA3131654A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962810716P 2019-02-26 2019-02-26
US62/810,716 2019-02-26
US201962930190P 2019-11-04 2019-11-04
US62/930,190 2019-11-04
PCT/IB2020/051559 WO2020174370A2 (en) 2019-02-26 2020-02-24 Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies

Publications (1)

Publication Number Publication Date
CA3131654A1 true CA3131654A1 (en) 2020-09-03

Family

ID=72142314

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3131654A Pending CA3131654A1 (en) 2019-02-26 2020-02-24 Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies

Country Status (16)

Country Link
US (3) US11459391B2 (https=)
EP (1) EP3931224A4 (https=)
JP (3) JP7703448B2 (https=)
KR (1) KR20210132117A (https=)
CN (1) CN113840842A (https=)
AU (1) AU2020229467A1 (https=)
BR (1) BR112021016149A2 (https=)
CA (1) CA3131654A1 (https=)
IL (1) IL285718A (https=)
JO (1) JOP20210233A1 (https=)
MA (1) MA55089A (https=)
MX (1) MX2021010265A (https=)
NZ (1) NZ778579A (https=)
PH (1) PH12021552030A1 (https=)
SG (1) SG11202108311RA (https=)
WO (1) WO2020174370A2 (https=)

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KR20240051145A (ko) * 2021-07-29 2024-04-19 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 Kras 돌연변이 암의 치료를 위한 방법 및 조성물
KR102793991B1 (ko) 2021-10-06 2025-04-09 주식회사 엘지에너지솔루션 태양광 시스템과 연계하는 에너지 저장 시스템 및 에너지 저장 시스템의 제어 방법
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Also Published As

Publication number Publication date
US12215161B2 (en) 2025-02-04
EP3931224A4 (en) 2023-03-01
JP2022521610A (ja) 2022-04-11
IL285718A (en) 2021-10-31
CN113840842A (zh) 2021-12-24
JOP20210233A1 (ar) 2023-01-30
WO2020174370A3 (en) 2020-12-03
AU2020229467A1 (en) 2021-08-12
JP2025084739A (ja) 2025-06-03
US20200270351A1 (en) 2020-08-27
US20250236675A1 (en) 2025-07-24
SG11202108311RA (en) 2021-09-29
MX2021010265A (es) 2021-09-23
WO2020174370A2 (en) 2020-09-03
JP7703448B2 (ja) 2025-07-07
EP3931224A2 (en) 2022-01-05
JP2024153659A (ja) 2024-10-29
MA55089A (fr) 2022-01-05
US20230130600A1 (en) 2023-04-27
PH12021552030A1 (en) 2022-08-15
US11459391B2 (en) 2022-10-04
KR20210132117A (ko) 2021-11-03
BR112021016149A2 (pt) 2021-10-13
NZ778579A (en) 2026-03-27

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