CA3129252A1 - Method of safe administration of phosphorylated tau peptide vaccine - Google Patents

Method of safe administration of phosphorylated tau peptide vaccine Download PDF

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Publication number
CA3129252A1
CA3129252A1 CA3129252A CA3129252A CA3129252A1 CA 3129252 A1 CA3129252 A1 CA 3129252A1 CA 3129252 A CA3129252 A CA 3129252A CA 3129252 A CA3129252 A CA 3129252A CA 3129252 A1 CA3129252 A1 CA 3129252A1
Authority
CA
Canada
Prior art keywords
seq
nmoles
tau
per dose
lig
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3129252A
Other languages
English (en)
French (fr)
Inventor
Andrea Pfeifer
Andreas Muhs
Maria Pihlgren Bosch
Marija Vukicevic Verhille
Nicolas Piot
Saroj Raj Ghimire
Elizabeth Anne Ramsburg
Donata DE MARCO
Charlotte Sadaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AC Immune SA
Janssen Pharmaceuticals Inc
Original Assignee
AC Immune SA
Janssen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AC Immune SA, Janssen Pharmaceuticals Inc filed Critical AC Immune SA
Publication of CA3129252A1 publication Critical patent/CA3129252A1/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0007—Nervous system antigens; Prions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018—Lipids, e.g. in lipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
CA3129252A 2019-02-08 2020-02-07 Method of safe administration of phosphorylated tau peptide vaccine Pending CA3129252A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962802870P 2019-02-08 2019-02-08
US62/802,870 2019-02-08
PCT/US2020/017235 WO2020163730A2 (en) 2019-02-08 2020-02-07 Method of safe administration of phosphorylated tau peptide vaccine

Publications (1)

Publication Number Publication Date
CA3129252A1 true CA3129252A1 (en) 2020-08-13

Family

ID=69780323

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3129252A Pending CA3129252A1 (en) 2019-02-08 2020-02-07 Method of safe administration of phosphorylated tau peptide vaccine

Country Status (17)

Country Link
US (3) US11684576B2 (enExample)
EP (1) EP3920966A2 (enExample)
JP (2) JP7541527B2 (enExample)
KR (1) KR20210125048A (enExample)
CN (1) CN113710269A (enExample)
AU (1) AU2020219804A1 (enExample)
BR (1) BR112021014794A2 (enExample)
CA (1) CA3129252A1 (enExample)
EA (1) EA202192203A1 (enExample)
IL (1) IL285163B2 (enExample)
JO (1) JOP20210211A1 (enExample)
MX (1) MX2021009508A (enExample)
MY (1) MY206596A (enExample)
PH (1) PH12021551876A1 (enExample)
SG (1) SG11202108312PA (enExample)
TW (1) TWI868106B (enExample)
WO (1) WO2020163730A2 (enExample)

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CA3228878A1 (en) * 2021-08-12 2023-02-16 Andrea Pfeifer Liposomes containing phosphorylated tau peptides for inducing sustained immune responses
US20250134991A1 (en) * 2021-08-20 2025-05-01 Thomas Jefferson University Monophosphoryl lipid adjuvant (mpla) compositions, vaccine compositions thereof, and methods of preparing and using the same

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Also Published As

Publication number Publication date
WO2020163730A2 (en) 2020-08-13
US12324855B2 (en) 2025-06-10
US20230381108A1 (en) 2023-11-30
MY206596A (en) 2024-12-25
CN113710269A (zh) 2021-11-26
US20200253873A1 (en) 2020-08-13
BR112021014794A2 (pt) 2021-10-05
TWI868106B (zh) 2025-01-01
JP2022520060A (ja) 2022-03-28
KR20210125048A (ko) 2021-10-15
PH12021551876A1 (en) 2022-05-23
US20250275920A1 (en) 2025-09-04
SG11202108312PA (en) 2021-08-30
EA202192203A1 (ru) 2021-10-20
IL285163B2 (en) 2025-05-01
AU2020219804A1 (en) 2021-08-19
MX2021009508A (es) 2021-09-08
JOP20210211A1 (ar) 2023-01-30
TW202045204A (zh) 2020-12-16
IL285163B1 (en) 2025-01-01
EP3920966A2 (en) 2021-12-15
IL285163A (en) 2021-09-30
JP2024178161A (ja) 2024-12-24
WO2020163730A3 (en) 2020-09-24
US11684576B2 (en) 2023-06-27
JP7541527B2 (ja) 2024-08-28

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