CA3127256A1 - High density lipoprotein mimetic nanoparticles using lipid conjugated core scaffolds - Google Patents

High density lipoprotein mimetic nanoparticles using lipid conjugated core scaffolds Download PDF

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Publication number
CA3127256A1
CA3127256A1 CA3127256A CA3127256A CA3127256A1 CA 3127256 A1 CA3127256 A1 CA 3127256A1 CA 3127256 A CA3127256 A CA 3127256A CA 3127256 A CA3127256 A CA 3127256A CA 3127256 A1 CA3127256 A1 CA 3127256A1
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CA
Canada
Prior art keywords
hdl
spherical
dna
core
spherical hdl
Prior art date
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Pending
Application number
CA3127256A
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English (en)
French (fr)
Inventor
Stephen E. HENRICH
C. Shad Thaxton
Sonbinh T. Nguyen
Bong Jin Hong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Northwestern University
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Northwestern University
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Publication of CA3127256A1 publication Critical patent/CA3127256A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1275—Lipoproteins or protein-free species thereof, e.g. chylomicrons; Artificial high-density lipoproteins [HDL], low-density lipoproteins [LDL] or very-low-density lipoproteins [VLDL]; Precursors thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/544—Phospholipids
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    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6917—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a lipoprotein vesicle, e.g. HDL or LDL proteins
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nanotechnology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
CA3127256A 2019-01-24 2020-01-24 High density lipoprotein mimetic nanoparticles using lipid conjugated core scaffolds Pending CA3127256A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962796534P 2019-01-24 2019-01-24
US62/796,534 2019-01-24
PCT/US2020/015109 WO2020154705A1 (en) 2019-01-24 2020-01-24 High-density lipoprotein mimetic nanoparticles using lipid conjugated core scaffolds

Publications (1)

Publication Number Publication Date
CA3127256A1 true CA3127256A1 (en) 2020-07-30

Family

ID=71736549

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3127256A Pending CA3127256A1 (en) 2019-01-24 2020-01-24 High density lipoprotein mimetic nanoparticles using lipid conjugated core scaffolds

Country Status (9)

Country Link
US (1) US12502354B2 (https=)
EP (1) EP3914236A4 (https=)
JP (1) JP7546927B2 (https=)
CN (1) CN113613635A (https=)
AU (2) AU2020210881A1 (https=)
CA (1) CA3127256A1 (https=)
MX (1) MX2021008940A (https=)
SG (1) SG11202107156WA (https=)
WO (1) WO2020154705A1 (https=)

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US20240117355A1 (en) * 2021-06-01 2024-04-11 Tionlab Therapeutics Lipoprotein-mimicking solid lipid nanoparticles for drug delivery and uses thereof

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