AU2020210881A1 - High-density lipoprotein mimetic nanoparticles using lipid conjugated core scaffolds - Google Patents

High-density lipoprotein mimetic nanoparticles using lipid conjugated core scaffolds Download PDF

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Publication number
AU2020210881A1
AU2020210881A1 AU2020210881A AU2020210881A AU2020210881A1 AU 2020210881 A1 AU2020210881 A1 AU 2020210881A1 AU 2020210881 A AU2020210881 A AU 2020210881A AU 2020210881 A AU2020210881 A AU 2020210881A AU 2020210881 A1 AU2020210881 A1 AU 2020210881A1
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AU
Australia
Prior art keywords
hdl
spherical
dna
core
spherical hdl
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Abandoned
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AU2020210881A
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English (en)
Inventor
Stephen E. HENRICH
Bong Jin Hong
Sonbinh T. Nguyen
C. Shad Thaxton
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Northwestern University
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Northwestern University
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Publication date
Application filed by Northwestern University filed Critical Northwestern University
Publication of AU2020210881A1 publication Critical patent/AU2020210881A1/en
Priority to AU2025260005A priority Critical patent/AU2025260005A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1275—Lipoproteins or protein-free species thereof, e.g. chylomicrons; Artificial high-density lipoproteins [HDL], low-density lipoproteins [LDL] or very-low-density lipoproteins [VLDL]; Precursors thereof
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    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • C—CHEMISTRY; METALLURGY
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    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C—CHEMISTRY; METALLURGY
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    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nanotechnology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
AU2020210881A 2019-01-24 2020-01-24 High-density lipoprotein mimetic nanoparticles using lipid conjugated core scaffolds Abandoned AU2020210881A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2025260005A AU2025260005A1 (en) 2019-01-24 2025-11-03 High-density lipoprotein mimetic nanoparticles using lipid conjugated core scaffolds

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962796534P 2019-01-24 2019-01-24
US62/796,534 2019-01-24
PCT/US2020/015109 WO2020154705A1 (en) 2019-01-24 2020-01-24 High-density lipoprotein mimetic nanoparticles using lipid conjugated core scaffolds

Related Child Applications (1)

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AU2025260005A Division AU2025260005A1 (en) 2019-01-24 2025-11-03 High-density lipoprotein mimetic nanoparticles using lipid conjugated core scaffolds

Publications (1)

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AU2020210881A1 true AU2020210881A1 (en) 2021-07-22

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AU2020210881A Abandoned AU2020210881A1 (en) 2019-01-24 2020-01-24 High-density lipoprotein mimetic nanoparticles using lipid conjugated core scaffolds
AU2025260005A Pending AU2025260005A1 (en) 2019-01-24 2025-11-03 High-density lipoprotein mimetic nanoparticles using lipid conjugated core scaffolds

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US (1) US12502354B2 (https=)
EP (1) EP3914236A4 (https=)
JP (1) JP7546927B2 (https=)
CN (1) CN113613635A (https=)
AU (2) AU2020210881A1 (https=)
CA (1) CA3127256A1 (https=)
MX (1) MX2021008940A (https=)
SG (1) SG11202107156WA (https=)
WO (1) WO2020154705A1 (https=)

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