CA3124102A1 - Nouveau derive d'hydrazone avec un groupe aryle ou heteroaryle substitue au niveau d'un groupe amine terminal de celui-ci et son utilisation - Google Patents

Nouveau derive d'hydrazone avec un groupe aryle ou heteroaryle substitue au niveau d'un groupe amine terminal de celui-ci et son utilisation Download PDF

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CA3124102A1
CA3124102A1 CA3124102A CA3124102A CA3124102A1 CA 3124102 A1 CA3124102 A1 CA 3124102A1 CA 3124102 A CA3124102 A CA 3124102A CA 3124102 A CA3124102 A CA 3124102A CA 3124102 A1 CA3124102 A1 CA 3124102A1
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Prior art keywords
dicyanide
carbonohydrazonoyl
phenyl
preparation
thiazol
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CA3124102A
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CA3124102C (fr
Inventor
Ae Nim Pae
Yun Kyung Kim
Sang Min Lim
Sungsu Lim
Jihye SEONG
Jae Wook Lee
Ji Yeon Song
Seulgi SHIN
Hyean Jeong JEONG
Woo Seung Son
Haeun LEE
Da Mi Lim
Seok Kyu Kim
Jee Yun Ahn
Chae Won Kim
Ashwini Machhindra LONDHE
Lizaveta GOTINA
Hyojin Kim
Hye Yeon Lee
Nam Gyung Kim
Eunji CHA
Kunhee KIM
Ji Woong Lim
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Korea Advanced Institute of Science and Technology KAIST
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Korea Advanced Institute of Science and Technology KAIST
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Publication of CA3124102A1 publication Critical patent/CA3124102A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07C255/00—Carboxylic acid nitriles
    • C07C255/63—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C255/65—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to nitrogen atoms
    • C07C255/66—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to nitrogen atoms having cyano groups and nitrogen atoms being part of hydrazine or hydrazone groups bound to the same carbon skeleton
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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Abstract

La présente invention concerne de nouveaux dérivés d'hydrazone avec un groupe aryle ou hétéroaryle substitué au niveau du groupe amine terminal de ceux-ci et une utilisation de ceux-ci.
CA3124102A 2018-12-19 2018-12-26 Nouveau derive d'hydrazone avec un groupe aryle ou heteroaryle substitue au niveau d'un groupe amine terminal de celui-ci et son utilisation Active CA3124102C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020180165400A KR102128509B1 (ko) 2018-12-19 2018-12-19 말단 아민기에 아릴 또는 헤테로아릴기가 치환된 신규한 히드라존 유도체 및 이의 용도
KR10-2018-0165400 2018-12-19
PCT/KR2018/016679 WO2020130214A1 (fr) 2018-12-19 2018-12-26 Nouveau dérivé d'hydrazone avec un groupe aryle ou hétéroaryle substitué au niveau d'un groupe amine terminal de celui-ci et son utilisation

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CA3124102A1 true CA3124102A1 (fr) 2020-06-25
CA3124102C CA3124102C (fr) 2023-10-17

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US (1) US20220396553A1 (fr)
EP (1) EP3901139A4 (fr)
JP (1) JP7375019B2 (fr)
KR (1) KR102128509B1 (fr)
CN (1) CN113727972A (fr)
AU (1) AU2018453188B2 (fr)
BR (1) BR112021012004A2 (fr)
CA (1) CA3124102C (fr)
MX (1) MX2021007464A (fr)
WO (1) WO2020130214A1 (fr)

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CN115867277A (zh) * 2020-06-19 2023-03-28 韩国科学技术研究院 新型稠合杂环基-碳腙酰二腈化合物及其用途
WO2021256902A1 (fr) * 2020-06-19 2021-12-23 한국과학기술연구원 Composé de carbonohydrazonoyl dicyanide comprenant au moins deux types d'aryle ou d'hétéroaryle liés par un nouveau lieur, et son utilisation
KR102356644B1 (ko) * 2020-06-19 2022-01-28 한국과학기술연구원 신규한 옥소피리다지닐-페닐-카르보노하이드라조노일 디시아나이드 화합물 및 이의 용도
CN112500353B (zh) * 2020-12-08 2022-11-25 北京晨光同创医药研究院有限公司 一种左西孟旦的前药化合物、制备方法及其应用
EP4294793A1 (fr) * 2021-02-19 2023-12-27 The Regents on the University of California Compositions et méthodes de traitement de tauopathies

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JPH07206800A (ja) * 1993-11-30 1995-08-08 Hodogaya Chem Co Ltd フェニルヒドラゾン誘導体
US5981168A (en) * 1998-05-15 1999-11-09 The University Of British Columbia Method and composition for modulating amyloidosis
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US6436915B1 (en) * 2000-04-07 2002-08-20 Kinetek Pharmaceuticals, Inc. Pyrazole compounds
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EP1572682A4 (fr) 2002-12-20 2008-01-23 Pharmacia Corp Composés de pyrazole acyclique
EP1612204A4 (fr) * 2003-03-31 2007-04-11 Daiichi Seiyaku Co Derive d'hydrazone
GB0419416D0 (en) 2004-09-01 2004-10-06 Inst Of Ex Botany Ascr 4-Arylazo-3,5-Diamino-Pyrazole compounds and use thereof
EP1791818A1 (fr) 2004-09-14 2007-06-06 The Genetics Company, Inc. Derives d'hydrazone et leur utilisation comme inhibiteurs de la beta-secretase
US20070207093A1 (en) * 2005-11-03 2007-09-06 Linquagen Corp. Hydrazone derivatives and uses thereof
ES2650744T3 (es) 2010-12-14 2018-01-22 Electrophoretics Limited Inhibidores de la caseína quinasa 1 delta (CK1delta)
WO2015112902A2 (fr) 2014-01-23 2015-07-30 Sova Pharmaceuticals, Inc. Inhibiteurs de cystathionine- (gamma)-lyase (cse) pour le traitement de la douleur
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US9962384B1 (en) * 2017-09-07 2018-05-08 Korea Institute Of Science And Technology Levosimendan compound for preventing or treating tau-related diseases

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BR112021012004A2 (pt) 2021-09-08
EP3901139A1 (fr) 2021-10-27
KR20200076808A (ko) 2020-06-30
AU2018453188A1 (en) 2021-07-08
EP3901139A4 (fr) 2022-10-05
CA3124102C (fr) 2023-10-17
AU2018453188B2 (en) 2023-01-19
WO2020130214A1 (fr) 2020-06-25
CN113727972A (zh) 2021-11-30
JP7375019B2 (ja) 2023-11-07
KR102128509B1 (ko) 2020-07-01
JP2022515787A (ja) 2022-02-22
MX2021007464A (es) 2021-12-10
US20220396553A1 (en) 2022-12-15

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