CA3115233A1 - Large scale generation of functional megakaryocytes and platelets from human embryonic stem cells under stromal-free conditions - Google Patents
Large scale generation of functional megakaryocytes and platelets from human embryonic stem cells under stromal-free conditionsInfo
- Publication number
- CA3115233A1 CA3115233A1 CA3115233A CA3115233A CA3115233A1 CA 3115233 A1 CA3115233 A1 CA 3115233A1 CA 3115233 A CA3115233 A CA 3115233A CA 3115233 A CA3115233 A CA 3115233A CA 3115233 A1 CA3115233 A1 CA 3115233A1
- Authority
- CA
- Canada
- Prior art keywords
- cells
- platelets
- megakaryocytes
- stem cells
- medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1394—Bone marrow stromal cells; whole marrow
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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| US61/384,165 | 2010-09-17 | ||
| CA2782013A CA2782013C (en) | 2009-12-04 | 2010-12-03 | Large scale generation of functional megakaryocytes and platelets from human embryonic stem cells under stromal-free conditions |
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| US8961956B2 (en) | 2011-11-30 | 2015-02-24 | Ocata Therapeutics, Inc. | Mesenchymal stromal cells and uses related thereto |
| TWI812867B (zh) | 2011-11-30 | 2023-08-21 | 安斯泰來再生醫藥協會 | 利用血管母細胞產生間葉基質細胞之方法 |
| GB201210857D0 (en) | 2012-06-19 | 2012-08-01 | Cambridge Entpr Ltd | Transcription factor mediated programming towards megakaryocytes |
| CA2876499C (en) | 2012-07-12 | 2021-10-26 | Imstem Biotechnology, Inc. | Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof |
| US9074186B2 (en) | 2012-08-15 | 2015-07-07 | Boston Medical Center Corporation | Production of red blood cells and platelets from stem cells |
| CN105101979B (zh) * | 2012-12-21 | 2021-10-08 | 安斯泰来再生医药协会 | 由多能干细胞制备血小板的方法及其组合物 |
| JP6580329B2 (ja) | 2014-03-31 | 2019-09-25 | シスメックス株式会社 | 未分化細胞から分化細胞および／または分化細胞の産生物を取得する方法 |
| US10538738B2 (en) | 2014-05-19 | 2020-01-21 | Eleftherios Papoutsakis | Megakaryocytic particles and microparticles for cell therapy and fate modification of stem and progenitor cells |
| AU2016242823A1 (en) * | 2015-03-30 | 2017-09-21 | Jeffrey Thomas Loh | Methods for producing modified red blood cell compositions, compositions and uses thereof |
| IL299326A (en) | 2015-08-18 | 2023-02-01 | Astellas Inst For Regenerative Medicine | Clinical formulations |
| KR102689261B1 (ko) * | 2015-10-14 | 2024-07-30 | 가부시키가이샤 메가카리온 | 정제 혈소판의 제조 방법 |
| CA3087344A1 (en) | 2018-01-05 | 2019-07-11 | Platelet Biogenesis, Inc. | Compositions and methods for producing megakaryocytes |
| EP3813853A4 (en) | 2018-06-29 | 2022-04-06 | Platelet Biogenesis, Inc. | DELIVERY COMPOSITIONS AND METHODS OF USE |
| JP2023526308A (ja) | 2020-05-11 | 2023-06-21 | ストーム バイオ インコーポレイテッド | 巨核球由来細胞外小胞に関連する組成物及び方法 |
| CA3213792A1 (en) | 2021-04-26 | 2022-11-03 | Jonathan Thon | Compositions and methods related to megakaryocyte-derived extracellular vesicles for fanconi anemia |
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| US5128259A (en) | 1989-10-27 | 1992-07-07 | Hahnemann University | Factor-dependent hematopoietic cell line exhibiting epo-induced erythrocyte maturation |
| WO2003004995A2 (en) * | 2001-01-29 | 2003-01-16 | Rich Ivan N | High-throughput stem cell assay of hematopoietic stem and progenitor cell proliferation |
| US20030027330A1 (en) | 2001-04-02 | 2003-02-06 | Robert Lanza | Method for facilitating the production of differentiated cell types and tissues from embryonic and adult pluripotent and multipotent cells |
| AU2002360424A1 (en) | 2001-11-26 | 2003-06-10 | Advanced Cell Technology, Inc. | Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells |
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| US20040229350A1 (en) | 2003-05-12 | 2004-11-18 | Nikolai Strelchenko | Morula derived embryonic stem cells |
| CN1286970C (zh) | 2003-12-30 | 2006-11-29 | 上海伯瑞生物技术发展有限公司 | 由脐血cd34+细胞体外诱导生成巨核细胞的方法 |
| EP1735429A4 (en) | 2004-03-31 | 2008-06-11 | Newlink Genetics Corp | METHOD AND COMPOSITIONS FOR OBTAINING EMBRYONAL STEM CELLS OF ABSTINENT HEMATOPOETIC STEM CELLS AND USES THEREOF |
| AU2005302258B2 (en) | 2004-11-01 | 2010-10-21 | Wisconsin Alumni Research Foundation | Platelets from stem cells |
| US7893315B2 (en) | 2004-11-04 | 2011-02-22 | Advanced Cell Technology, Inc. | Derivation of embryonic stem cells and embryo-derived cells |
| WO2007095064A2 (en) | 2006-02-09 | 2007-08-23 | Wisconsin Alumni Research Foundation | ERYTHROID CELLS PRODUCING ADULT-TYPE β-HEMOGLOBIN GENERATED FROM HUMAN EMBRYONIC STEM CELLS |
| CN101045914A (zh) | 2006-03-29 | 2007-10-03 | 中国人民解放军军事医学科学院野战输血研究所 | 体外诱导造血干/祖细胞分化为成熟红细胞的方法与应用 |
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| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| US9683232B2 (en) | 2007-12-10 | 2017-06-20 | Kyoto University | Efficient method for nuclear reprogramming |
| CA3150872A1 (en) | 2008-05-06 | 2009-11-12 | Astellas Institute For Regenerative Medicine | Methods for producing enucleated erythroid cells derived from pluripotent stem cells |
| MX2010012088A (es) | 2008-05-06 | 2011-07-28 | Advanced Cell Tech Inc | Celulas que forman colonias de hemangiomas y celulas de hemangioma sin injertar. |
| IN2012DN05054A (enExample) | 2009-12-04 | 2015-10-09 | Stem Call & Regenerative Medicine International Inc |
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| JP2019122385A (ja) | 2019-07-25 |
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| AU2019203670A1 (en) | 2019-06-13 |
| US20120315338A1 (en) | 2012-12-13 |
| CA2782013C (en) | 2021-06-08 |
| CA2782013A1 (en) | 2011-06-09 |
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| JP2013512676A (ja) | 2013-04-18 |
| KR20180086301A (ko) | 2018-07-30 |
| KR20120128605A (ko) | 2012-11-27 |
| AU2022200188A1 (en) | 2022-02-10 |
| EP2507359A4 (en) | 2015-05-13 |
| AU2019203670B2 (en) | 2021-10-14 |
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