CA3102600A1 - Centrifuge system for separating cells in suspension - Google Patents
Centrifuge system for separating cells in suspension Download PDFInfo
- Publication number
- CA3102600A1 CA3102600A1 CA3102600A CA3102600A CA3102600A1 CA 3102600 A1 CA3102600 A1 CA 3102600A1 CA 3102600 A CA3102600 A CA 3102600A CA 3102600 A CA3102600 A CA 3102600A CA 3102600 A1 CA3102600 A1 CA 3102600A1
- Authority
- CA
- Canada
- Prior art keywords
- centrate
- concentrate
- pump
- opening
- chamber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000725 suspension Substances 0.000 title description 24
- 239000012141 concentrate Substances 0.000 claims abstract description 484
- 239000012530 fluid Substances 0.000 claims abstract description 103
- 239000000463 material Substances 0.000 claims abstract description 57
- 238000000926 separation method Methods 0.000 claims description 153
- 230000003287 optical effect Effects 0.000 claims description 62
- 238000004113 cell culture Methods 0.000 claims description 38
- 238000012545 processing Methods 0.000 claims description 36
- 238000004891 communication Methods 0.000 claims description 25
- 238000007789 sealing Methods 0.000 claims description 12
- 239000006285 cell suspension Substances 0.000 abstract description 20
- 239000007787 solid Substances 0.000 abstract description 5
- 210000004027 cell Anatomy 0.000 description 139
- 239000007788 liquid Substances 0.000 description 75
- 238000000034 method Methods 0.000 description 31
- 239000003085 diluting agent Substances 0.000 description 22
- 230000008569 process Effects 0.000 description 20
- 238000013016 damping Methods 0.000 description 18
- 238000013459 approach Methods 0.000 description 16
- 239000002245 particle Substances 0.000 description 14
- 238000005086 pumping Methods 0.000 description 12
- 230000007423 decrease Effects 0.000 description 11
- 230000037361 pathway Effects 0.000 description 11
- 230000009471 action Effects 0.000 description 10
- 230000002572 peristaltic effect Effects 0.000 description 10
- 230000006870 function Effects 0.000 description 9
- 230000035899 viability Effects 0.000 description 8
- 238000011072 cell harvest Methods 0.000 description 7
- 230000007246 mechanism Effects 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 239000000356 contaminant Substances 0.000 description 6
- 238000011109 contamination Methods 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 230000008901 benefit Effects 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 238000007906 compression Methods 0.000 description 4
- 230000006835 compression Effects 0.000 description 4
- 239000008394 flocculating agent Substances 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 238000004062 sedimentation Methods 0.000 description 4
- 238000010008 shearing Methods 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 3
- 230000003833 cell viability Effects 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000005779 cell damage Effects 0.000 description 2
- 208000037887 cell injury Diseases 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 238000009295 crossflow filtration Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 238000003306 harvesting Methods 0.000 description 2
- 229920001903 high density polyethylene Polymers 0.000 description 2
- 230000002706 hydrostatic effect Effects 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000012007 large scale cell culture Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000013341 scale-up Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229920001169 thermoplastic Polymers 0.000 description 2
- 239000004416 thermosoftening plastic Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 239000004697 Polyetherimide Substances 0.000 description 1
- 229920002873 Polyethylenimine Polymers 0.000 description 1
- 208000034809 Product contamination Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229920006318 anionic polymer Polymers 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229920006317 cationic polymer Polymers 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000011118 depth filtration Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000012145 high-salt buffer Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000013072 incoming material Substances 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 229920001993 poloxamer 188 Polymers 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920001601 polyetherimide Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000004114 suspension culture Methods 0.000 description 1
- 229920002725 thermoplastic elastomer Polymers 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B11/00—Feeding, charging, or discharging bowls
- B04B11/04—Periodical feeding or discharging; Control arrangements therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
- B01D21/262—Separation of sediment aided by centrifugal force or centripetal force by using a centrifuge
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/30—Control equipment
- B01D21/32—Density control of clear liquid or sediment, e.g. optical control ; Control of physical properties
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B11/00—Feeding, charging, or discharging bowls
- B04B11/02—Continuous feeding or discharging; Control arrangements therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B11/00—Feeding, charging, or discharging bowls
- B04B11/08—Skimmers or scrapers for discharging ; Regulating thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B11/00—Feeding, charging, or discharging bowls
- B04B11/08—Skimmers or scrapers for discharging ; Regulating thereof
- B04B11/082—Skimmers for discharging liquid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B13/00—Control arrangements specially designed for centrifuges; Programme control of centrifuges
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B7/00—Elements of centrifuges
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B7/00—Elements of centrifuges
- B04B7/08—Rotary bowls
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2221/00—Applications of separation devices
- B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
- B04B2005/0464—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with hollow or massive core in centrifuge bowl
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Sustainable Development (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Centrifugal Separators (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862682376P | 2018-06-08 | 2018-06-08 | |
| US62/682,376 | 2018-06-08 | ||
| PCT/US2019/035855 WO2019236895A1 (en) | 2018-06-08 | 2019-06-06 | Centrifuge system for separating cells in suspension |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA3102600A1 true CA3102600A1 (en) | 2019-12-12 |
| CA3102600C CA3102600C (en) | 2024-06-11 |
Family
ID=68770662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3102600A Active CA3102600C (en) | 2018-06-08 | 2019-06-06 | Centrifuge system for separating cells in suspension |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP3801920A4 (es) |
| JP (1) | JP7336467B2 (es) |
| KR (2) | KR102568313B1 (es) |
| CN (2) | CN115254458A (es) |
| AU (1) | AU2019280856B2 (es) |
| CA (1) | CA3102600C (es) |
| MX (2) | MX2020011898A (es) |
| WO (1) | WO2019236895A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11065629B2 (en) * | 2011-11-21 | 2021-07-20 | Pneumatic Scale Corporation | Centrifuge system for separating cells in suspension |
| US20220212207A9 (en) * | 2011-11-21 | 2022-07-07 | Pneumatic Scale Corporation | Centrifuge system for separating cells in suspension |
| US11878312B2 (en) * | 2011-11-21 | 2024-01-23 | Pneumatic Scale Corporation | Centrifuge system for separating cells in suspension |
| US11957998B2 (en) * | 2019-06-06 | 2024-04-16 | Pneumatic Scale Corporation | Centrifuge system for separating cells in suspension |
| KR20230058077A (ko) * | 2020-08-22 | 2023-05-02 | 수닐 메타 | 다양한 혼합물로부터 성분을 연속적으로 분리하기 위한 자동 원심분리 장치 및 방법 |
| CN114682397B (zh) * | 2022-03-28 | 2024-03-15 | 浙江大学 | 锥形液液轴向离心分离器及分离监控装置 |
| WO2023196391A1 (en) * | 2022-04-07 | 2023-10-12 | Mirror Biologics, Inc. | Artificial lymph node bioreator |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA894304A (en) * | 1972-02-29 | Fujisawa Mitsumaro | Embossing film with compressed air on recessed drum and applying second film | |
| DE941267C (de) * | 1950-01-19 | 1956-04-05 | Separator Ab | Schleudermaschine fuer die kontinuierliche Trennung und Austragung fester Bestandteile aus einem Fluessigkeitsgemisch |
| CA1057254A (en) * | 1976-05-14 | 1979-06-26 | Baxter Travenol Laboratories | Disposable centrifugal blood processing system |
| DE3231070A1 (de) * | 1982-08-19 | 1984-08-23 | Herwig 1000 Berlin Michel-Kim | Vorrichtung zur austragung von in silos gelagerten stoffen |
| EP0257755B1 (en) * | 1986-07-22 | 1991-07-03 | Haemonetics Corporation | Centrifuge bowl or rotor for plasmapheresis |
| US5318500A (en) * | 1992-10-15 | 1994-06-07 | Eli Lilly And Company | Method for controlling intermittently discharged centrifuges |
| CH687505A5 (fr) * | 1993-01-29 | 1996-12-31 | Elp Rochat | Séparateur centrifuge pour fluides. |
| US5637217A (en) * | 1995-01-25 | 1997-06-10 | Fleetguard, Inc. | Self-driven, cone-stack type centrifuge |
| DK0868215T3 (da) * | 1995-12-01 | 2002-05-06 | Baker Hughes Inc | Fremgangsmåde og apparat til styring og overvågning af en centrifuge med kontinuerlig tilførsel |
| JPH09192215A (ja) * | 1996-01-17 | 1997-07-29 | Takaharu Nakane | 遠心ボウル |
| JP3313572B2 (ja) * | 1996-04-03 | 2002-08-12 | ヘモネティクス・コーポレーション | 血液処理用遠心分離器ボウル |
| DE19715661A1 (de) * | 1997-04-16 | 1998-10-22 | Mann & Hummel Filter | Zentrifugenrotor |
| JP3817079B2 (ja) * | 1998-10-05 | 2006-08-30 | テルモ株式会社 | 血液成分採取装置 |
| US6629919B2 (en) * | 1999-06-03 | 2003-10-07 | Haemonetics Corporation | Core for blood processing apparatus |
| EP1688183A1 (fr) * | 2005-02-03 | 2006-08-09 | Jean-Denis Rochat | Procede et dispositif jetable pour la separation par centrifugation d'un liquide physiologique |
| US7628749B2 (en) * | 2005-09-01 | 2009-12-08 | Wagner Development Inc. | Solids recovery using cross-flow microfilter and automatic piston discharge centrifuge |
| CN201094937Y (zh) * | 2007-09-18 | 2008-08-06 | 江苏牡丹离心机制造有限公司 | 一种吊袋式离心机中的挤袋装置 |
| US9222067B2 (en) * | 2008-04-22 | 2015-12-29 | Pneumatic Scale Corporation | Single use centrifuge system for highly concentrated and/or turbid feeds |
| VN29235A1 (es) * | 2009-06-04 | 2012-03-26 | ||
| WO2012137086A1 (en) * | 2011-04-08 | 2012-10-11 | Sorin Group Italia S.R.L. | Disposable device for centrifugal blood separation |
| WO2015186057A1 (en) * | 2014-06-04 | 2015-12-10 | Biosafe S.A. | System for multi-processing and separation of biological fluids |
| DE102014118289A1 (de) * | 2014-12-10 | 2016-06-16 | Gea Mechanical Equipment Gmbh | Separator |
| US9833557B2 (en) * | 2014-12-19 | 2017-12-05 | Fenwal, Inc. | Systems and methods for determining free plasma hemoglobin |
| DE102015105988B3 (de) * | 2015-04-20 | 2016-05-25 | Hiller Gmbh | Vorrichtung zum kontinuierlichen Trennen fließfähiger Stoffe unterschiedlicher Dichte in einer Zentrifuge |
| CN107735120B (zh) * | 2015-07-13 | 2021-06-15 | 美国血液技术公司 | 用于从回收的血液中清除脂肪的系统和方法 |
| CN107921445A (zh) * | 2015-09-07 | 2018-04-17 | 曼·胡默尔有限公司 | 用于离心分离器的转子的带密封件的内衬 |
| CN106238229B (zh) * | 2016-08-31 | 2018-07-24 | 苏州盛天力离心机制造有限公司 | 抽滤离心机转鼓组件 |
-
2019
- 2019-06-06 CN CN202210885991.0A patent/CN115254458A/zh active Pending
- 2019-06-06 AU AU2019280856A patent/AU2019280856B2/en active Active
- 2019-06-06 JP JP2020567836A patent/JP7336467B2/ja active Active
- 2019-06-06 CN CN201980038216.8A patent/CN112236236A/zh active Pending
- 2019-06-06 WO PCT/US2019/035855 patent/WO2019236895A1/en active Application Filing
- 2019-06-06 KR KR1020207031612A patent/KR102568313B1/ko active IP Right Grant
- 2019-06-06 EP EP19815510.3A patent/EP3801920A4/en active Pending
- 2019-06-06 KR KR1020227009017A patent/KR102568314B1/ko active IP Right Grant
- 2019-06-06 CA CA3102600A patent/CA3102600C/en active Active
- 2019-06-06 MX MX2020011898A patent/MX2020011898A/es unknown
-
2020
- 2020-11-06 MX MX2022003223A patent/MX2022003223A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3102600C (en) | 2024-06-11 |
| JP2021526957A (ja) | 2021-10-11 |
| CN112236236A (zh) | 2021-01-15 |
| MX2022003223A (es) | 2022-04-12 |
| KR20220039841A (ko) | 2022-03-29 |
| KR20210018796A (ko) | 2021-02-18 |
| EP3801920A4 (en) | 2022-07-13 |
| AU2019280856B2 (en) | 2022-06-30 |
| EP3801920A1 (en) | 2021-04-14 |
| BR112020025083A2 (pt) | 2021-03-23 |
| AU2022204733A1 (en) | 2022-07-21 |
| KR102568314B1 (ko) | 2023-08-18 |
| AU2019280856A1 (en) | 2020-12-17 |
| KR102568313B1 (ko) | 2023-08-18 |
| WO2019236895A1 (en) | 2019-12-12 |
| CN115254458A (zh) | 2022-11-01 |
| JP7336467B2 (ja) | 2023-08-31 |
| MX2020011898A (es) | 2021-01-15 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request |
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Effective date: 20210528 |