CA3091782A1 - 2,2,2-trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl) methylene] hydrazide polymorphs and method of making the same - Google Patents
2,2,2-trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl) methylene] hydrazide polymorphs and method of making the same Download PDFInfo
- Publication number
- CA3091782A1 CA3091782A1 CA3091782A CA3091782A CA3091782A1 CA 3091782 A1 CA3091782 A1 CA 3091782A1 CA 3091782 A CA3091782 A CA 3091782A CA 3091782 A CA3091782 A CA 3091782A CA 3091782 A1 CA3091782 A1 CA 3091782A1
- Authority
- CA
- Canada
- Prior art keywords
- solvent
- amorphous
- trifluoroacetic acid
- water
- crystalline form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/72—Hydrazones
- C07C251/86—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/16—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of hydrazones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862633441P | 2018-02-21 | 2018-02-21 | |
| US62/633,441 | 2018-02-21 | ||
| PCT/US2019/018835 WO2019164997A1 (en) | 2018-02-21 | 2019-02-20 | 2,2,2-trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl) methylene] hydrazide polymorphs and method of making the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3091782A1 true CA3091782A1 (en) | 2019-08-29 |
Family
ID=67686904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3091782A Pending CA3091782A1 (en) | 2018-02-21 | 2019-02-20 | 2,2,2-trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl) methylene] hydrazide polymorphs and method of making the same |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10968167B2 (https=) |
| EP (1) | EP3755316A4 (https=) |
| JP (2) | JP2021525275A (https=) |
| CN (1) | CN113747892A (https=) |
| CA (1) | CA3091782A1 (https=) |
| WO (1) | WO2019164997A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021525275A (ja) * | 2018-02-21 | 2021-09-24 | オニール, マイケルO’NEIL, Michael | ２，２，２−トリフルオロ酢酸１−（２，４−ジメチルフェニル）−２−［（３−メトキシフェニル）メチレン］ ヒドラジド多形体およびその製造方法 |
| WO2021222438A1 (en) * | 2020-04-28 | 2021-11-04 | Abrexa Pharmaceuticals, Inc. | Compounds for prevention and treatment of post-intensive care cognitive dysfunction and cognitive dysfunction resulting from respiratory distress |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8779002B2 (en) | 2007-10-15 | 2014-07-15 | Salk Institute For Biological Studies | Methods for treating a variety of diseases and conditions, and compounds useful therefor |
| CN105801496B (zh) * | 2014-12-31 | 2018-03-13 | 广州喜鹊医药有限公司 | 三氟乙酰肼类化合物及其制备方法和在制药中的应用 |
| WO2017015660A1 (en) * | 2015-07-23 | 2017-01-26 | Salk Institute For Biological Studies | Prevention and treatment of aging and neurodegenerative diseases |
| JP2021525275A (ja) * | 2018-02-21 | 2021-09-24 | オニール, マイケルO’NEIL, Michael | ２，２，２−トリフルオロ酢酸１−（２，４−ジメチルフェニル）−２−［（３−メトキシフェニル）メチレン］ ヒドラジド多形体およびその製造方法 |
-
2019
- 2019-02-20 JP JP2020567741A patent/JP2021525275A/ja active Pending
- 2019-02-20 WO PCT/US2019/018835 patent/WO2019164997A1/en not_active Ceased
- 2019-02-20 CA CA3091782A patent/CA3091782A1/en active Pending
- 2019-02-20 EP EP19758167.1A patent/EP3755316A4/en active Pending
- 2019-02-20 CN CN201980025349.1A patent/CN113747892A/zh active Pending
- 2019-02-20 US US16/975,054 patent/US10968167B2/en active Active
-
2021
- 2021-01-17 US US17/151,198 patent/US11584711B2/en active Active
-
2023
- 2023-12-25 JP JP2023218036A patent/JP2024038090A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3755316A1 (en) | 2020-12-30 |
| CN113747892A (zh) | 2021-12-03 |
| JP2021525275A (ja) | 2021-09-24 |
| US11584711B2 (en) | 2023-02-21 |
| US20210139416A1 (en) | 2021-05-13 |
| WO2019164997A1 (en) | 2019-08-29 |
| US10968167B2 (en) | 2021-04-06 |
| JP2024038090A (ja) | 2024-03-19 |
| US20200399205A1 (en) | 2020-12-24 |
| EP3755316A4 (en) | 2022-05-25 |
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