CA3087044A1 - Expression of metabolic modulators in tumor microenvironment to improve tumor therapy - Google Patents

Expression of metabolic modulators in tumor microenvironment to improve tumor therapy Download PDF

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Publication number
CA3087044A1
CA3087044A1 CA3087044A CA3087044A CA3087044A1 CA 3087044 A1 CA3087044 A1 CA 3087044A1 CA 3087044 A CA3087044 A CA 3087044A CA 3087044 A CA3087044 A CA 3087044A CA 3087044 A1 CA3087044 A1 CA 3087044A1
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Canada
Prior art keywords
protein
tumor
leptin
virus
oncolytic virus
Prior art date
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Pending
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CA3087044A
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English (en)
French (fr)
Inventor
Greg M. Delgoffe
Dayana RIVADENEIRA
Padmavathi Sampath
Stephen H. Thorne
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University of Pittsburgh
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University of Pittsburgh
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Publication of CA3087044A1 publication Critical patent/CA3087044A1/en
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/76—Viruses; Subviral particles; Bacteriophages
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/575—Hormones
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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CA3087044A 2018-01-26 2019-01-28 Expression of metabolic modulators in tumor microenvironment to improve tumor therapy Pending CA3087044A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862622547P 2018-01-26 2018-01-26
US62/622,547 2018-01-26
PCT/US2019/015434 WO2019148109A1 (en) 2018-01-26 2019-01-28 Expression of metabolic modulators in tumor microenvironment to improve tumor therapy

Publications (1)

Publication Number Publication Date
CA3087044A1 true CA3087044A1 (en) 2019-08-01

Family

ID=67396217

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3087044A Pending CA3087044A1 (en) 2018-01-26 2019-01-28 Expression of metabolic modulators in tumor microenvironment to improve tumor therapy

Country Status (8)

Country Link
US (1) US11786569B2 (https=)
EP (1) EP3720283A4 (https=)
JP (2) JP2021511060A (https=)
KR (1) KR102849901B1 (https=)
CN (1) CN111655845A (https=)
AU (1) AU2019212840B2 (https=)
CA (1) CA3087044A1 (https=)
WO (1) WO2019148109A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3973973A1 (en) 2017-10-31 2022-03-30 KaliVir Immunotherapeutics, Inc. Platform oncolytic vector for systemic delivery
TWI852977B (zh) 2019-01-10 2024-08-21 美商健生生物科技公司 前列腺新抗原及其用途
KR20220115569A (ko) 2019-11-18 2022-08-17 얀센 바이오테크 인코포레이티드 돌연변이 calr 및 jak2에 기반한 백신 및 이의 용도
US20220409684A1 (en) * 2019-11-18 2022-12-29 The Brigham And Women's Hospital, Inc. Codon optimized new generation regulatable fusogenic oncolytic herpes simplex virus type 1 virus and methods of use
US12295997B2 (en) 2020-07-06 2025-05-13 Janssen Biotech, Inc. Prostate neoantigens and their uses
WO2022047220A1 (en) * 2020-08-27 2022-03-03 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Oncolytic viruses encoding recombinant tranforming growth factor (tgf)-beta monomers and uses thereof
CA3197371A1 (en) * 2020-11-19 2022-05-27 Kalivir Immunotherapeutics, Inc. Oncolytic immunotherapy by tumor micro-environment remodeling
EP4329786A4 (en) 2021-04-30 2024-12-11 KaliVir Immunotherapeutics, Inc. Oncolytic viruses for modified mhc expression
CN116286911A (zh) * 2022-10-21 2023-06-23 上海鑫湾生物科技有限公司 一种响应缺氧环境调控病毒复制的可剪接系统及其用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1252260C (zh) 2000-07-21 2006-04-19 上海三维生物技术有限公司 肿瘤特异性启动子
US8969291B2 (en) 2004-10-08 2015-03-03 Enzo Therapeutics, Inc. Methods for decreasing leptin levels or activity for treating inflammation
KR101542275B1 (ko) * 2007-11-19 2015-08-06 트랜스진 에스.에이. 폭스바이러스성 온콜리틱 벡터
CA2709292A1 (en) * 2009-07-10 2011-01-10 The Governors Of The University Of Alberta Oncolytic viruses and methods for treating neoplastic disorders
DK3169341T3 (da) 2014-07-16 2019-08-05 Transgene Sa Onkolytisk virus til ekspression af immun-checkpoint-modulatorer
HK1255192A1 (zh) 2015-09-08 2019-08-09 Sillajen, Inc. 表达细胞因子和羧酸酯酶的修饰的溶瘤痘苗病毒及其使用方法
KR102016128B1 (ko) * 2015-09-21 2019-08-29 주식회사 엘지화학 이차전지용 전극의 제조 방법 및 이에 따라 제조된 이차전지용 전극

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Publication number Publication date
JP2021511060A (ja) 2021-05-06
EP3720283A1 (en) 2020-10-14
KR102849901B1 (ko) 2025-08-22
JP2024029176A (ja) 2024-03-05
EP3720283A4 (en) 2021-09-08
KR20200116086A (ko) 2020-10-08
US20200330534A1 (en) 2020-10-22
AU2019212840A1 (en) 2020-07-16
US11786569B2 (en) 2023-10-17
AU2019212840B2 (en) 2024-08-15
CN111655845A (zh) 2020-09-11
WO2019148109A1 (en) 2019-08-01

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