CA3087044A1 - Expression of metabolic modulators in tumor microenvironment to improve tumor therapy - Google Patents

Expression of metabolic modulators in tumor microenvironment to improve tumor therapy Download PDF

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Publication number
CA3087044A1
CA3087044A1 CA3087044A CA3087044A CA3087044A1 CA 3087044 A1 CA3087044 A1 CA 3087044A1 CA 3087044 A CA3087044 A CA 3087044A CA 3087044 A CA3087044 A CA 3087044A CA 3087044 A1 CA3087044 A1 CA 3087044A1
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Canada
Prior art keywords
protein
tumor
leptin
virus
oncolytic virus
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Pending
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CA3087044A
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English (en)
French (fr)
Inventor
Greg M. Delgoffe
Dayana RIVADENEIRA
Padmavathi Sampath
Stephen H. Thorne
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University of Pittsburgh
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University of Pittsburgh
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Publication of CA3087044A1 publication Critical patent/CA3087044A1/en
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    • A61K35/763—Herpes virus
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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CA3087044A 2018-01-26 2019-01-28 Expression of metabolic modulators in tumor microenvironment to improve tumor therapy Pending CA3087044A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862622547P 2018-01-26 2018-01-26
US62/622,547 2018-01-26
PCT/US2019/015434 WO2019148109A1 (en) 2018-01-26 2019-01-28 Expression of metabolic modulators in tumor microenvironment to improve tumor therapy

Publications (1)

Publication Number Publication Date
CA3087044A1 true CA3087044A1 (en) 2019-08-01

Family

ID=67396217

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3087044A Pending CA3087044A1 (en) 2018-01-26 2019-01-28 Expression of metabolic modulators in tumor microenvironment to improve tumor therapy

Country Status (8)

Country Link
US (1) US11786569B2 (https=)
EP (1) EP3720283A4 (https=)
JP (2) JP2021511060A (https=)
KR (1) KR102849901B1 (https=)
CN (1) CN111655845A (https=)
AU (1) AU2019212840B2 (https=)
CA (1) CA3087044A1 (https=)
WO (1) WO2019148109A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3703723A4 (en) 2017-10-31 2021-12-15 KaliVir Immunotherapeutics, Inc. ONCOLYTIC PLATFORM VECTOR FOR SYSTEMS ADMINISTRATION
TWI852977B (zh) 2019-01-10 2024-08-21 美商健生生物科技公司 前列腺新抗原及其用途
CR20220220A (es) 2019-11-18 2022-09-20 Janssen Biotech Inc Vacunas basadas en calr y jak2 mutantes y sus usos
WO2021101796A1 (en) * 2019-11-18 2021-05-27 The Brigham And Women's Hospital, Inc. Codon optimized new generation regulatable fusogenic oncolytic herpes simplex virus type 1 virus and methods of use
EP4175664A2 (en) 2020-07-06 2023-05-10 Janssen Biotech, Inc. Prostate neoantigens and their uses
JP2023539195A (ja) * 2020-08-27 2023-09-13 ユニバーシティ オブ ピッツバーグ － オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 組換えトランスフォーミング増殖因子（ｔｇｆ）－ベータ単量体をコードする腫瘍溶解性ウイルスおよびその使用
TW202227621A (zh) * 2020-11-19 2022-07-16 美商凱立凡爾免疫治療股份有限公司 重塑腫瘤微環境的溶瘤免疫療法
BR112023022681A2 (pt) 2021-04-30 2024-01-23 Kalivir Immunotherapeutics Inc Vírus oncolíticos para expressão modificada de mhc
CN116286911A (zh) * 2022-10-21 2023-06-23 上海鑫湾生物科技有限公司 一种响应缺氧环境调控病毒复制的可剪接系统及其用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4845327B2 (ja) * 2000-07-21 2011-12-28 千葉県 腫瘍特異的プロモーター
US8969291B2 (en) * 2004-10-08 2015-03-03 Enzo Therapeutics, Inc. Methods for decreasing leptin levels or activity for treating inflammation
HRP20150360T1 (hr) * 2007-11-19 2015-05-08 Transgene Sa Poksvirusni onkolitiäśki vektori
CA2709292A1 (en) 2009-07-10 2011-01-10 The Governors Of The University Of Alberta Oncolytic viruses and methods for treating neoplastic disorders
RU2696312C2 (ru) * 2014-07-16 2019-08-01 Трансген Са Онколитический вирус для экспрессии модуляторов иммунологических контрольных точек
WO2017043815A1 (en) * 2015-09-08 2017-03-16 Sillajen, Inc. Modified oncolytic vaccinia viruses expressing a cytokine and a car- boxylesterase and methods of use thereof
KR102016128B1 (ko) * 2015-09-21 2019-08-29 주식회사 엘지화학 이차전지용 전극의 제조 방법 및 이에 따라 제조된 이차전지용 전극

Also Published As

Publication number Publication date
US20200330534A1 (en) 2020-10-22
EP3720283A1 (en) 2020-10-14
WO2019148109A1 (en) 2019-08-01
KR20200116086A (ko) 2020-10-08
KR102849901B1 (ko) 2025-08-22
JP2021511060A (ja) 2021-05-06
CN111655845A (zh) 2020-09-11
US11786569B2 (en) 2023-10-17
AU2019212840B2 (en) 2024-08-15
EP3720283A4 (en) 2021-09-08
AU2019212840A1 (en) 2020-07-16
JP2024029176A (ja) 2024-03-05

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