CA3079374A1 - Treatment of cd20-positive b-cell lymphoma with obituzumab - Google Patents

Treatment of cd20-positive b-cell lymphoma with obituzumab Download PDF

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Publication number
CA3079374A1
CA3079374A1 CA3079374A CA3079374A CA3079374A1 CA 3079374 A1 CA3079374 A1 CA 3079374A1 CA 3079374 A CA3079374 A CA 3079374A CA 3079374 A CA3079374 A CA 3079374A CA 3079374 A1 CA3079374 A1 CA 3079374A1
Authority
CA
Canada
Prior art keywords
obinutuzumab
hour
cycle
administration
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3079374A
Other languages
English (en)
French (fr)
Inventor
Michael Wenger
Mehrdad Mobasher
Chin-Yu Lin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=64362606&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA3079374(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA3079374A1 publication Critical patent/CA3079374A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
CA3079374A 2017-10-19 2018-10-19 Treatment of cd20-positive b-cell lymphoma with obituzumab Pending CA3079374A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762574297P 2017-10-19 2017-10-19
US62/574,297 2017-10-19
PCT/JP2018/038924 WO2019017499A2 (en) 2017-10-19 2018-10-19 PHARMACEUTICAL COMPOSITION

Publications (1)

Publication Number Publication Date
CA3079374A1 true CA3079374A1 (en) 2019-01-24

Family

ID=64362606

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3079374A Pending CA3079374A1 (en) 2017-10-19 2018-10-19 Treatment of cd20-positive b-cell lymphoma with obituzumab

Country Status (14)

Country Link
US (2) US12129304B2 (cg-RX-API-DMAC7.html)
EP (2) EP3697818B1 (cg-RX-API-DMAC7.html)
JP (2) JP6860652B2 (cg-RX-API-DMAC7.html)
KR (1) KR102766089B1 (cg-RX-API-DMAC7.html)
CN (2) CN111212854A (cg-RX-API-DMAC7.html)
AU (2) AU2018303836B2 (cg-RX-API-DMAC7.html)
BR (1) BR112020007731A2 (cg-RX-API-DMAC7.html)
CA (1) CA3079374A1 (cg-RX-API-DMAC7.html)
ES (1) ES3005784T3 (cg-RX-API-DMAC7.html)
IL (2) IL321935A (cg-RX-API-DMAC7.html)
MX (2) MX419643B (cg-RX-API-DMAC7.html)
PL (1) PL3697818T3 (cg-RX-API-DMAC7.html)
TW (2) TWI805630B (cg-RX-API-DMAC7.html)
WO (1) WO2019017499A2 (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI805630B (zh) * 2017-10-19 2023-06-21 瑞士商赫孚孟拉羅股份公司 醫藥組合物
AU2020356896A1 (en) * 2019-10-04 2022-05-19 Chugai Seiyaku Kabushiki Kaisha Inhibitor of cell proliferation in obinutuzumab resistant CD20-positive cancer, and medicinal composition, medicine, production, method for inhibiting cell proliferation, therapeutic method, type II anti-CD20 antibody, compounds, combination of same, enhancer and inducer, each relating thereto
CN117941219A (zh) 2021-09-17 2024-04-26 佳能株式会社 送电设备和受电设备

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS55723B1 (sr) 2003-11-05 2017-07-31 Roche Glycart Ag Molekuli koji se vezuju za antigen sa povećanim afinitetom vezivanja za fc receptor i efektornom funkcijom
ES2511844T3 (es) 2007-12-21 2014-10-23 F. Hoffmann-La Roche Ag Formulación de anticuerpo
HRP20220738T1 (hr) 2014-08-11 2022-08-19 Acerta Pharma B.V. Terapijske kombinacije inhibitora btk, inhibitora pd-1 i/ili inhibitora pd-l1
US11149091B2 (en) * 2015-12-09 2021-10-19 Cedars-Sinai Medical Center Methods for treating nephrotic syndrome
CN108395482B (zh) 2017-02-08 2021-02-05 西比曼生物科技（香港）有限公司 一种靶向cd20抗原嵌合抗原受体的构建及其工程化t细胞的活性鉴定
EP3656814B1 (en) 2017-07-21 2025-12-24 The Yokohama Rubber Co., Ltd. Pneumatic tire
TWI805630B (zh) * 2017-10-19 2023-06-21 瑞士商赫孚孟拉羅股份公司 醫藥組合物

Also Published As

Publication number Publication date
IL273909A (en) 2020-05-31
JP6860652B2 (ja) 2021-04-21
BR112020007731A2 (pt) 2020-10-20
IL273909B1 (en) 2025-08-01
AU2018303836A1 (en) 2020-05-14
KR20200067196A (ko) 2020-06-11
MX419643B (es) 2025-01-14
MX2020003418A (es) 2020-07-20
ES3005784T3 (en) 2025-03-17
JP2019528282A (ja) 2019-10-10
TWI805630B (zh) 2023-06-21
JP2021152002A (ja) 2021-09-30
TWI828593B (zh) 2024-01-01
AU2018303836B2 (en) 2025-04-17
KR102766089B1 (ko) 2025-02-13
EP3697818B1 (en) 2024-11-27
US20200299398A1 (en) 2020-09-24
IL273909B2 (en) 2025-12-01
US20250026847A1 (en) 2025-01-23
PL3697818T3 (pl) 2025-03-24
AU2025205481A1 (en) 2025-08-07
KR20240157135A (ko) 2024-10-31
TW202342099A (zh) 2023-11-01
EP4520347A3 (en) 2025-06-04
IL321935A (en) 2025-09-01
TW201922284A (zh) 2019-06-16
EP4520347A2 (en) 2025-03-12
WO2019017499A3 (en) 2019-02-21
JP7370357B2 (ja) 2023-10-27
CN111212854A (zh) 2020-05-29
US12129304B2 (en) 2024-10-29
MX2024009217A (es) 2024-11-08
EP3697818A2 (en) 2020-08-26
CN120983618A (zh) 2025-11-21
WO2019017499A2 (en) 2019-01-24

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Effective date: 20230922