CA3077749A1 - Srpk1 inhibitors - Google Patents

Info

Publication number

CA3077749A1

CA3077749A1 CA3077749A CA3077749A CA3077749A1 CA 3077749 A1 CA3077749 A1 CA 3077749A1 CA 3077749 A CA3077749 A CA 3077749A CA 3077749 A CA3077749 A CA 3077749A CA 3077749 A1 CA3077749 A1 CA 3077749A1

Authority

CA

Canada

Prior art keywords

methyl

compound

hydrogen

cyclopropyl

ethyl

Prior art date

2017-09-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 238000011282 treatment Methods 0.000 claims abstract description 76
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• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 110
• -1 methoxy, methyl Chemical group 0.000 claims description 94
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• 229910052739 hydrogen Inorganic materials 0.000 claims description 66
• 239000001257 hydrogen Substances 0.000 claims description 66
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 66
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 64
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 54
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 50
• 125000000623 heterocyclic group Chemical group 0.000 claims description 49
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 46
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 41
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 39
• 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims description 34
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 33
• 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 28
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 28
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