CA3072767A1 - Novel nicotine-binding antibodies - Google Patents
Novel nicotine-binding antibodies Download PDFInfo
- Publication number
- CA3072767A1 CA3072767A1 CA3072767A CA3072767A CA3072767A1 CA 3072767 A1 CA3072767 A1 CA 3072767A1 CA 3072767 A CA3072767 A CA 3072767A CA 3072767 A CA3072767 A CA 3072767A CA 3072767 A1 CA3072767 A1 CA 3072767A1
- Authority
- CA
- Canada
- Prior art keywords
- nicotine
- seq
- chain sequence
- light chain
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Addiction (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762545696P | 2017-08-15 | 2017-08-15 | |
| US62/545,696 | 2017-08-15 | ||
| PCT/US2018/046621 WO2019036419A1 (en) | 2017-08-15 | 2018-08-14 | NEW NICOTINE BINDING ANTIBODIES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3072767A1 true CA3072767A1 (en) | 2019-02-21 |
Family
ID=63405495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3072767A Pending CA3072767A1 (en) | 2017-08-15 | 2018-08-14 | Novel nicotine-binding antibodies |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11440970B2 (https=) |
| EP (2) | EP4624496A3 (https=) |
| JP (1) | JP7364555B2 (https=) |
| KR (1) | KR102712005B1 (https=) |
| CN (1) | CN111432883B (https=) |
| AU (1) | AU2018317372B2 (https=) |
| BR (1) | BR112020002994A2 (https=) |
| CA (1) | CA3072767A1 (https=) |
| ES (1) | ES3041362T3 (https=) |
| MX (1) | MX2020001725A (https=) |
| WO (1) | WO2019036419A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3801594A1 (en) * | 2018-06-06 | 2021-04-14 | Antidote Therapeutics, Inc. | Methods for improving circulation and treating cardiovascular disease |
| KR102530111B1 (ko) * | 2022-03-11 | 2023-05-10 | 앱클론(주) | 코티닌을 표적하는 항체 또는 그의 항원 결합 단편, 이를 포함하는 키메라 항원 수용체 및 이들의 용도 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0194158A3 (en) * | 1985-03-08 | 1988-02-24 | Baylor College of Medicine | Anti-nicotine and anti-cotinine antibodies (monoclonal and other), and their uses in nicotine and cotinine assays |
| US6232082B1 (en) | 1998-12-01 | 2001-05-15 | Nabi | Hapten-carrier conjugates for treating and preventing nicotine addiction |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| WO2002058635A2 (en) | 2001-01-26 | 2002-08-01 | The Scripps Research Institute | Nicotine immunogens and antibodies and uses thereof |
| US20050089524A1 (en) | 2002-03-01 | 2005-04-28 | Sanderson Sam D. | Compositions and compounds for use as molecular adjuvant for a nicotine vaccine |
| US8546543B2 (en) | 2004-11-12 | 2013-10-01 | Xencor, Inc. | Fc variants that extend antibody half-life |
| US20060111271A1 (en) | 2004-11-24 | 2006-05-25 | Cerny Erich H | Active and passive immunization against pharmacologically active hapten molecules using a synthetic carrier compound composed of similar elements |
| US8316104B2 (en) * | 2005-11-15 | 2012-11-20 | California Institute Of Technology | Method and apparatus for collaborative system |
| EP1963308A4 (en) | 2005-11-28 | 2010-12-15 | Nabi Biopharmaceuticals | METHOD FOR PRODUCING A NICOTINE HAPTEN |
| WO2007100755A1 (en) | 2006-02-27 | 2007-09-07 | Nabi Biopharmaceuticals | Method for decreasing the toxic effects of nicotine on fetuses in pregnant women |
| EP2065398A1 (en) | 2007-11-29 | 2009-06-03 | Cytos Biotechnology AG | Human monoclonal nicotine specific antibodies |
| EP2222702B1 (en) * | 2007-11-29 | 2016-01-13 | Cytos Biotechnology AG | Human monoclonal nicotine specific antibodies |
| JP2011524521A (ja) | 2008-06-13 | 2011-09-01 | ナビ バイオファーマシューティカルズ | 喫煙停止キットおよび方法 |
-
2018
- 2018-08-14 US US16/639,050 patent/US11440970B2/en active Active
- 2018-08-14 JP JP2020509479A patent/JP7364555B2/ja active Active
- 2018-08-14 EP EP25191604.5A patent/EP4624496A3/en active Pending
- 2018-08-14 KR KR1020207007504A patent/KR102712005B1/ko active Active
- 2018-08-14 MX MX2020001725A patent/MX2020001725A/es unknown
- 2018-08-14 AU AU2018317372A patent/AU2018317372B2/en active Active
- 2018-08-14 EP EP18760233.9A patent/EP3668598B1/en active Active
- 2018-08-14 CN CN201880067101.7A patent/CN111432883B/zh active Active
- 2018-08-14 ES ES18760233T patent/ES3041362T3/es active Active
- 2018-08-14 CA CA3072767A patent/CA3072767A1/en active Pending
- 2018-08-14 BR BR112020002994-7A patent/BR112020002994A2/pt not_active Application Discontinuation
- 2018-08-14 WO PCT/US2018/046621 patent/WO2019036419A1/en not_active Ceased
-
2022
- 2022-08-12 US US17/819,577 patent/US20230089068A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20200089255A (ko) | 2020-07-24 |
| CN111432883B (zh) | 2024-10-01 |
| WO2019036419A1 (en) | 2019-02-21 |
| EP3668598A1 (en) | 2020-06-24 |
| EP3668598B1 (en) | 2025-07-30 |
| US20230089068A1 (en) | 2023-03-23 |
| AU2018317372A1 (en) | 2020-03-05 |
| US11440970B2 (en) | 2022-09-13 |
| ES3041362T3 (en) | 2025-11-11 |
| EP4624496A3 (en) | 2025-12-17 |
| US20200377616A1 (en) | 2020-12-03 |
| AU2018317372B2 (en) | 2025-06-26 |
| BR112020002994A2 (pt) | 2020-08-11 |
| MX2020001725A (es) | 2020-08-20 |
| KR102712005B1 (ko) | 2024-09-30 |
| JP2020531480A (ja) | 2020-11-05 |
| JP7364555B2 (ja) | 2023-10-18 |
| CN111432883A (zh) | 2020-07-17 |
| EP4624496A2 (en) | 2025-10-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Kosten et al. | Immunotherapy for the treatment of drug abuse | |
| ES2974803T3 (es) | Anticuerpos antagonistas dirigidos contra el péptido relacionado con el gen de la calcitonina y métodos para utilizarlos | |
| De Villiers et al. | Active immunization against nicotine suppresses nicotine-induced dopamine release in the rat nucleus accumbens shell | |
| Treweek et al. | An antidote for acute cocaine toxicity | |
| LeSage et al. | Current status of immunologic approaches to treating tobacco dependence: vaccines and nicotine-specific antibodies | |
| US20230089068A1 (en) | Novel nicotine-binding antibodies | |
| RS59354B1 (sr) | Postupci lečenja nosne polipoze davanjem il-4r antagonista | |
| JP2022120125A (ja) | 眼状態の治療方法 | |
| Escobar-Chávez et al. | Targeting nicotine addiction: the possibility of a therapeutic vaccine | |
| Rose | Disrupting nicotine reinforcement: from cigarette to brain | |
| KR20230030573A (ko) | 항-bet v1 항체를 사용하여 알러지를 치료하는 방법 | |
| CA2895702C (en) | Heroin haptens, immunoconjugates and related uses | |
| Chapman et al. | Substructure-specific antibodies against fentanyl derivatives | |
| Zheng et al. | Family of structurally related bioconjugates yields antibodies with differential selectivity against ketamine and 6-hydroxynorketamine | |
| US20220267474A1 (en) | Methods for improving circulation and treating cardiovascular disease | |
| Pashmi | Immunotherapy approach to combat nicotine addiction | |
| Barbosa-Mendez et al. | NIC6-TT Vaccine Attenuates Nicotine-Seeking and Expression of Nicotine-Induced Locomotor Sensitization in Rats | |
| Javors et al. | Neurobehavioral toxicology of substances of abuse | |
| Oliver | Vaccination against cotinine as a potential approach to smoking cessation | |
| Roiko | Passive immunization to treat nicotine dependence in rats | |
| Kim et al. | Supplementary Material The Potential Role of GLP-1 Receptor Agonists in Substance Use Disorders–A Systematic Review | |
| Coy | A nicotine conjugate vaccine attenuates the behavioral and cardiovascular effects of nicotine in rats | |
| Lin | Passive immunization against nicotine attenuates nicotine alleviation of nicotine abstinence syndrome | |
| Cornish | Enhancing the efficacy of a nicotine vaccine | |
| Sidhpura | Neurochemical interactions of nicotine and bupropion in the rat striatum |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20230629 |
|
| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 6TH ANNIV.) - STANDARD Year of fee payment: 6 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20240722 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT Effective date: 20240722 Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20240722 |
|
| D15 | Examination report completed |
Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D15-D126 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: EXAMINER'S REPORT Effective date: 20240816 |
|
| D00 | Search and/or examination requested or commenced |
Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D00-D120 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: VOLUNTARY SUBMISSION OF PRIOR ART RECEIVED Effective date: 20241212 |
|
| P11 | Amendment of application requested |
Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT RECEIVED - RESPONSE TO EXAMINER'S REQUISITION Effective date: 20241212 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT Effective date: 20250221 |
|
| P11 | Amendment of application requested |
Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT DETERMINED COMPLIANT Effective date: 20250612 |
|
| P13 | Application amended |
Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P13-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION AMENDED Effective date: 20250612 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT Effective date: 20250630 |
|
| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 7TH ANNIV.) - STANDARD Year of fee payment: 7 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250702 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20250702 |
|
| P11 | Amendment of application requested |
Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT DETERMINED COMPLIANT Effective date: 20250730 |
|
| P13 | Application amended |
Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P13-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION AMENDED Effective date: 20250730 |
|
| P13 | Application amended |
Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P13-P146 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: BSL VERIFIED - NO DEFECTS Effective date: 20250904 |
|
| D00 | Search and/or examination requested or commenced |
Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D00-D123 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: PRIOR ART DISCLOSURE DETERMINED COMPLIANT Effective date: 20250909 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20250909 |
|
| D22 | Grant of ip right intended |
Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D22-D128 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: ALLOWANCE REQUIREMENTS DETERMINED COMPLIANT Effective date: 20260210 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20260211 |