CA3072484C - An injection molded microfluidic/fluidic cartridge integrated with silicon-based sensor - Google Patents

An injection molded microfluidic/fluidic cartridge integrated with silicon-based sensor Download PDF

Info

Publication number
CA3072484C
CA3072484C CA3072484A CA3072484A CA3072484C CA 3072484 C CA3072484 C CA 3072484C CA 3072484 A CA3072484 A CA 3072484A CA 3072484 A CA3072484 A CA 3072484A CA 3072484 C CA3072484 C CA 3072484C
Authority
CA
Canada
Prior art keywords
channel
input
output
sensor
plastic substrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3072484A
Other languages
English (en)
French (fr)
Other versions
CA3072484A1 (en
Inventor
Chen Li
Cheng Frank Zhong
Yu Liu
Yiwen OUYANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MGI Tech Co Ltd
Original Assignee
MGI Tech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MGI Tech Co Ltd filed Critical MGI Tech Co Ltd
Publication of CA3072484A1 publication Critical patent/CA3072484A1/en
Application granted granted Critical
Publication of CA3072484C publication Critical patent/CA3072484C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/02—Drop detachment mechanisms of single droplets from nozzles or pins
    • B01L2400/027—Drop detachment mechanisms of single droplets from nozzles or pins electrostatic forces between substrate and tip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
CA3072484A 2017-09-01 2018-08-31 An injection molded microfluidic/fluidic cartridge integrated with silicon-based sensor Active CA3072484C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762553614P 2017-09-01 2017-09-01
US62/553,614 2017-09-01
PCT/US2018/049039 WO2019046690A1 (en) 2017-09-01 2018-08-31 INTEGRATED INJECTION MICROFLUIDIC / FLUID CARTRIDGE WITH SILICON-BASED SENSOR

Publications (2)

Publication Number Publication Date
CA3072484A1 CA3072484A1 (en) 2019-03-07
CA3072484C true CA3072484C (en) 2022-05-24

Family

ID=65517621

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3072484A Active CA3072484C (en) 2017-09-01 2018-08-31 An injection molded microfluidic/fluidic cartridge integrated with silicon-based sensor

Country Status (9)

Country Link
US (1) US11007523B2 (cg-RX-API-DMAC10.html)
EP (2) EP4382474A3 (cg-RX-API-DMAC10.html)
JP (2) JP7169345B2 (cg-RX-API-DMAC10.html)
KR (1) KR102387367B1 (cg-RX-API-DMAC10.html)
CN (1) CN111050913B (cg-RX-API-DMAC10.html)
AU (1) AU2018325527B2 (cg-RX-API-DMAC10.html)
CA (1) CA3072484C (cg-RX-API-DMAC10.html)
TW (1) TWI758537B (cg-RX-API-DMAC10.html)
WO (1) WO2019046690A1 (cg-RX-API-DMAC10.html)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019055007A1 (en) * 2017-09-14 2019-03-21 Hewlett-Packard Development Company, L.P. MICROFLUIDIC HOUSING
CN111855083B (zh) * 2019-04-19 2021-10-22 厦门大学 具有液流控制阀的微流控芯片的模拟检测装置及方法
DE102019112254A1 (de) * 2019-05-10 2020-11-12 Leonhard Kurz Stiftung & Co. Kg Mikrofluidische Anordnung, Verfahren zu deren Herstellung und Messsystem umfassend die mikrofluidische Anordnung sowie Verwendung
EP3965930A1 (de) 2019-05-10 2022-03-16 LEONHARD KURZ Stiftung & Co. KG Mikrofluidische anordnung, verfahren zu deren herstellung und messsystem umfassend die mikrofluidische anordnung sowie verwendung
AU2020279254B2 (en) 2019-05-21 2025-08-14 Illumina, Inc. Sensors having an active surface
CN111013676A (zh) * 2019-12-17 2020-04-17 江苏圣极基因科技有限公司 一种液滴制备方法及微流控芯片
TWI902731B (zh) 2019-12-30 2025-11-01 美商伊路米納有限公司 與流動池一同使用之致動系統及設備
US11808569B2 (en) * 2020-03-22 2023-11-07 Strike Photonics, Inc. Waveguide enhanced analyte detection apparatus
FR3114092B1 (fr) * 2020-09-17 2022-08-26 Commissariat Energie Atomique Procédé de fabrication d'un dispositif micro-fluidique et dispositif fabriqué par ledit procédé
TWI921436B (zh) 2021-01-15 2026-04-11 美商伊路米納有限公司 實現感測器頂側打線接合
US12678790B2 (en) * 2021-11-05 2026-07-14 Illumina, Inc. Sensor having an active surface
WO2024173811A1 (en) * 2023-02-17 2024-08-22 Twist Bioscience Corporation Vertical flow cell for biomolecule extraction
KR102938643B1 (ko) 2023-06-19 2026-03-13 (주)페블아이 현장검사를 위한 휴대용 바이오칩
DE102023126573A1 (de) * 2023-09-28 2025-04-03 Bürkert Werke GmbH & Co. KG Einweg-Fluidführungsbaugruppe, Verfahren zur Herstellung der Einweg-Fluidführungsbaugruppe, mikrofluidische Vorrichtung mit Einweg-Fluidführungsbaugruppe sowie Proteindefektdiagnosevorrichtung
WO2025242595A1 (en) * 2024-05-21 2025-11-27 Lex diagnostics Ltd. Fluidic cartridges with component-free valves

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ306051A (en) * 1995-03-10 1999-11-29 Meso Scale Technologies Llc Testing using electrochemiluminescence
CN1182920C (zh) * 1999-05-03 2005-01-05 坎森有限公司 用于微型流体处理系统的传感器
CN100402850C (zh) * 1999-06-28 2008-07-16 加利福尼亚技术学院 微型制造的弹性体的阀和泵系统
US6790599B1 (en) * 1999-07-15 2004-09-14 Microbionics, Inc. Microfluidic devices and manufacture thereof
AU2002230524A1 (en) 2000-11-16 2002-05-27 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
NL1016779C2 (nl) * 2000-12-02 2002-06-04 Cornelis Johannes Maria V Rijn Matrijs, werkwijze voor het vervaardigen van precisieproducten met behulp van een matrijs, alsmede precisieproducten, in het bijzonder microzeven en membraanfilters, vervaardigd met een dergelijke matrijs.
JP3990909B2 (ja) * 2001-12-26 2007-10-17 旭化成株式会社 化学反応用カートリッジ
US6878271B2 (en) 2002-09-09 2005-04-12 Cytonome, Inc. Implementation of microfluidic components in a microfluidic system
US7455770B2 (en) * 2002-09-09 2008-11-25 Cytonome, Inc. Implementation of microfluidic components in a microfluidic system
US7842234B2 (en) * 2002-12-02 2010-11-30 Epocal Inc. Diagnostic devices incorporating fluidics and methods of manufacture
JP2006512092A (ja) * 2002-12-30 2006-04-13 ザ・リージェンツ・オブ・ジ・ユニバーシティ・オブ・カリフォルニア 病原体の検出および分析のための方法および装置
EP1664601B1 (en) * 2003-08-11 2016-10-12 California Institute Of Technology Microfluidic large scale integration
NL1024578C2 (nl) * 2003-10-21 2005-04-22 Univ Delft Tech Inrichting voor het uitvoeren van een reactie.
US20060002817A1 (en) * 2004-06-30 2006-01-05 Sebastian Bohm Flow modulation devices
US7832429B2 (en) * 2004-10-13 2010-11-16 Rheonix, Inc. Microfluidic pump and valve structures and fabrication methods
WO2007029132A2 (en) * 2005-09-09 2007-03-15 Koninklijke Philips Electronics N. V. A method of manufacturing a microsystem, such a microsystem, a stack of foils comprising such a microsystem, an electronic device comprising such a microsystem and use of the electronic device
DE602006012205D1 (de) 2005-10-26 2010-03-25 Gen Electric Verfahren und systeme zur abgabe fluidischer proben in sensorarrays
EP2052260A4 (en) 2006-08-15 2010-08-25 Us Gov Sec Navy METHOD AND DEVICE FOR FIXING A LIQUID CELL ON A PLANAR SUBSTRATE
AU2007319975B2 (en) * 2006-11-09 2011-03-03 Sru Biosystems, Inc. Photonic crystal sensors with integrated fluid containment structure
CN105349647B (zh) * 2007-10-30 2020-08-28 完整基因有限公司 用于核酸高通量测序的方法
CN101580222B (zh) * 2008-05-15 2011-11-16 原相科技股份有限公司 微机电元件与制作方法
JP2011030522A (ja) * 2009-08-04 2011-02-17 Aida Engineering Ltd マイクロ流体デバイス
US9651568B2 (en) * 2009-11-23 2017-05-16 Cyvek, Inc. Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays
DE102010002915B4 (de) * 2010-03-16 2012-10-18 Senslab-Gesellschaft Zur Entwicklung Und Herstellung Bioelektrochemischer Sensoren Mbh Mikrofluidischer Sensor
JP5497587B2 (ja) * 2010-03-23 2014-05-21 株式会社日立ハイテクノロジーズ マイクロ流路チップ及びマイクロアレイチップ
WO2012024658A2 (en) 2010-08-20 2012-02-23 IntegenX, Inc. Integrated analysis system
US8828332B2 (en) * 2010-09-10 2014-09-09 Gradientech Ab Microfluidic capsule
US9387476B2 (en) * 2010-10-27 2016-07-12 Illumina, Inc. Flow cells for biological or chemical analysis
US8778848B2 (en) 2011-06-09 2014-07-15 Illumina, Inc. Patterned flow-cells useful for nucleic acid analysis
AU2012336040B2 (en) * 2011-11-07 2015-12-10 Illumina, Inc. Integrated sequencing apparatuses and methods of use
TW201319563A (zh) * 2011-11-08 2013-05-16 黃榮堂 整合ｉｃ晶片與塑膠微流體基板的檢測系統
CN103157523A (zh) * 2011-12-15 2013-06-19 三星电子株式会社 微流器件及其制造方法
US8895249B2 (en) 2012-06-15 2014-11-25 Illumina, Inc. Kinetic exclusion amplification of nucleic acid libraries
US9592507B2 (en) 2012-06-22 2017-03-14 Abbott Point Of Care Inc. Integrated cartridge housings for sample analysis
GB2516669B (en) * 2013-07-29 2015-09-09 Atlas Genetics Ltd A method for processing a liquid sample in a fluidic cartridge
EP3116651B1 (en) * 2014-03-11 2020-04-22 Illumina, Inc. Disposable, integrated microfluidic cartridge and methods of making it
RU2688746C2 (ru) * 2014-06-05 2019-05-22 Иллумина, Инк. Системы и способы с использованием поворотного клапана для по меньшей мере одного из приготовления образца или анализа образца
CN105624020B (zh) * 2014-11-07 2017-11-03 深圳华大基因研究院 用于检测dna片段的碱基序列的微流控芯片
CN105013550B (zh) * 2015-07-09 2016-08-24 清华大学深圳研究生院 微流控芯片夹具和微流控芯片
WO2017015123A1 (en) * 2015-07-17 2017-01-26 Boyd Lawrence M Apparatus and method for sorting of cells
CN108138229B (zh) * 2015-08-14 2022-07-26 亿明达股份有限公司 使用磁响应式传感器确定遗传特征的系统和方法
CN105293428B (zh) * 2015-10-19 2017-04-19 北京航天控制仪器研究所 一种mems器件的全硅化圆片级真空封装方法及封装器件
TWI611185B (zh) * 2015-12-19 2018-01-11 National Taipei University Of Technology 檢測裝置
US20170182493A1 (en) 2015-12-28 2017-06-29 QIAGEN Waltham Thin-film flowcells
CN105891285B (zh) * 2016-04-28 2018-08-10 中国科学院电子学研究所 高选择性富集和检测四溴双酚a的集成芯片及其应用
CN206184464U (zh) * 2016-11-25 2017-05-24 黑龙江东方学院 自动化的微流控接收装置

Also Published As

Publication number Publication date
US20190070606A1 (en) 2019-03-07
EP3676010A1 (en) 2020-07-08
KR102387367B1 (ko) 2022-04-14
TW201928331A (zh) 2019-07-16
CA3072484A1 (en) 2019-03-07
CN111050913B (zh) 2022-04-12
CN111050913A (zh) 2020-04-21
JP2020532722A (ja) 2020-11-12
JP7169345B2 (ja) 2022-11-10
KR20200042534A (ko) 2020-04-23
TWI758537B (zh) 2022-03-21
EP4382474A2 (en) 2024-06-12
AU2018325527A1 (en) 2020-02-27
EP3676010A4 (en) 2021-09-08
US11007523B2 (en) 2021-05-18
EP3676010B1 (en) 2024-07-03
EP4382474A3 (en) 2024-09-25
AU2018325527B2 (en) 2021-09-16
WO2019046690A1 (en) 2019-03-07
JP2023002784A (ja) 2023-01-10

Similar Documents

Publication Publication Date Title
EP3676010B1 (en) An injection molded microfluidic/fluidic cartridge integrated with silicon-based sensor
US8778280B2 (en) Microfluidic chips and assay systems
US8323887B2 (en) Miniaturized fluid delivery and analysis system
US7794611B2 (en) Micropump for integrated device for biological analyses
US20050233440A1 (en) Apparatus for biochemical analysis
CN102066948B (zh) 用于分析物处理的方法和装置
US20080311585A1 (en) System and method for multiplex liquid handling
US20080038713A1 (en) System and Method for Biological Assay
US20120085644A1 (en) Fluid delivery manifolds and microfluidic systems
US8007267B2 (en) System and method for making lab card by embossing
CN113396016B (zh) 诊断检测芯片装置以及制造和组装方法
CN105339087A (zh) 用于自动化化验的微流体装置
KR102942023B1 (ko) 반도체 검출 칩을 이용한 샘플 프로세싱의 시스템, 장치, 및 방법
US7278210B2 (en) Method for producing a 3-D microscope flow-through cell
KR100579831B1 (ko) 조립 가능한 미세유동형 바이오시료 처리장치
HK40021810A (en) An injection molded microfluidic/fluidic cartridge integrated with silicon-based sensor
HK40021810B (en) An injection molded microfluidic/fluidic cartridge integrated with silicon-based sensor
HK40018418A (en) An injection molded microfluidic/fluidic cartridge integrated with silicon-based sensor
US20250249450A1 (en) Diagnostic chip carrier device with gasket and methods of manufacture
CN106248979A (zh) 一次性反应液吸取反应器

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20210729

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 6TH ANNIV.) - STANDARD

Year of fee payment: 6

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20240724

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20240724

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 7TH ANNIV.) - STANDARD

Year of fee payment: 7

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250801

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250801