CA3067696C - Compose marque au 18f pour le diagnostic du cancer de la prostate et son utilisation - Google Patents
Compose marque au 18f pour le diagnostic du cancer de la prostate et son utilisation Download PDFInfo
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- CA3067696C CA3067696C CA3067696A CA3067696A CA3067696C CA 3067696 C CA3067696 C CA 3067696C CA 3067696 A CA3067696 A CA 3067696A CA 3067696 A CA3067696 A CA 3067696A CA 3067696 C CA3067696 C CA 3067696C
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- 230000004927 fusion Effects 0.000 description 1
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- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
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- 238000002347 injection Methods 0.000 description 1
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- 239000003446 ligand Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000003068 molecular probe Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- PIBWKRNGBLPSSY-UHFFFAOYSA-L palladium(II) chloride Chemical compound Cl[Pd]Cl PIBWKRNGBLPSSY-UHFFFAOYSA-L 0.000 description 1
- UQPUONNXJVWHRM-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 UQPUONNXJVWHRM-UHFFFAOYSA-N 0.000 description 1
- 210000003049 pelvic bone Anatomy 0.000 description 1
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- 235000003270 potassium fluoride Nutrition 0.000 description 1
- 201000007094 prostatitis Diseases 0.000 description 1
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- 229950010131 puromycin Drugs 0.000 description 1
- 239000002287 radioligand Substances 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 239000012321 sodium triacetoxyborohydride Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
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- 238000012546 transfer Methods 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical group OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
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- 238000002604 ultrasonography Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Nuclear Medicine (AREA)
Abstract
La présente invention concerne un composé marqué au 18F et une utilisation de celui-ci. Le composé, selon l'invention se lie de manière sélective à un antigène membranaire spécifique de la prostate (PSMA), et permet l'acquisition d'images claires du cancer de la prostate en un court laps de temps lorsqu'elle est utilisée en tomographie par émission de positrons (TEP).
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20170077570 | 2017-06-19 | ||
| KR10-2017-0077570 | 2017-06-19 | ||
| KR1020180069590A KR102015355B1 (ko) | 2017-06-19 | 2018-06-18 | 전립선암 진단을 위한 18f-표지된 화합물 및 그의 용도 |
| KR10-2018-0069590 | 2018-06-18 | ||
| PCT/KR2018/006869 WO2018236115A1 (fr) | 2017-06-19 | 2018-06-18 | Composé marqué au 18f pour le diagnostic du cancer de la prostate et son utilisation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA3067696A1 CA3067696A1 (fr) | 2018-12-27 |
| CA3067696C true CA3067696C (fr) | 2022-05-03 |
Family
ID=65008286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3067696A Active CA3067696C (fr) | 2017-06-19 | 2018-06-18 | Compose marque au 18f pour le diagnostic du cancer de la prostate et son utilisation |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US10870629B2 (fr) |
| EP (1) | EP3643707B1 (fr) |
| JP (1) | JP6913968B2 (fr) |
| KR (1) | KR102015355B1 (fr) |
| CN (1) | CN110770212B (fr) |
| AU (1) | AU2018288907B2 (fr) |
| CA (1) | CA3067696C (fr) |
| CL (1) | CL2019003727A1 (fr) |
| DK (1) | DK3643707T3 (fr) |
| EA (1) | EA037781B1 (fr) |
| ES (1) | ES2912392T3 (fr) |
| HR (1) | HRP20220557T1 (fr) |
| LT (1) | LT3643707T (fr) |
| MX (1) | MX2019015616A (fr) |
| MY (1) | MY195426A (fr) |
| PH (1) | PH12019502665A1 (fr) |
| PL (1) | PL3643707T3 (fr) |
| PT (1) | PT3643707T (fr) |
| RS (1) | RS63205B1 (fr) |
| SG (1) | SG11201911602RA (fr) |
| SI (1) | SI3643707T1 (fr) |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2318366T3 (pl) | 2008-08-01 | 2017-10-31 | Univ Johns Hopkins | Środki wiążące PSMA i ich zastosowania |
| EP2739316B1 (fr) * | 2011-08-05 | 2019-04-10 | Molecular Insight Pharmaceuticals, Inc. | Inhibiteurs radiomarqués d'antigène membranaire spécifique de la prostate |
| WO2013028664A1 (fr) * | 2011-08-22 | 2013-02-28 | Siemens Medical Solutions Usa, Inc. | Agents d'imagerie du psma |
| JP2014051442A (ja) * | 2012-09-05 | 2014-03-20 | Kyoto Univ | 前立腺がんを診断可能な核医学イメージングプローブ |
| HUE044552T2 (hu) | 2013-01-14 | 2019-11-28 | Molecular Insight Pharm Inc | Triazinalapú radiogyógyszerek és radiológiai képalkotó ágensek |
| EP3068747A1 (fr) | 2013-11-13 | 2016-09-21 | GE Healthcare Limited | Cassette à double traitement pour la synthèse de composés marqués par 18f |
| KR20150113801A (ko) * | 2014-03-31 | 2015-10-08 | 한미약품 주식회사 | Tak1 저해 활성을 갖는 피라진 접합고리 유도체 |
| FR3023290B1 (fr) * | 2014-07-04 | 2016-08-19 | Pf Medicament | Derives de flavaglines |
| WO2017027870A1 (fr) * | 2015-08-13 | 2017-02-16 | The Johns Hopkins University | Urées, thiourées, carbamates et cabarmates « inversés » conjugués à du triazole, pour agents d'imagerie ciblant l'antigène psma et leurs utilisations |
| SG10202013129YA (en) | 2016-06-28 | 2021-01-28 | Univ Cornell | 18f-labeled triazole containing psma inhibitors |
-
2018
- 2018-06-18 RS RS20220436A patent/RS63205B1/sr unknown
- 2018-06-18 EA EA202090071A patent/EA037781B1/ru not_active IP Right Cessation
- 2018-06-18 MY MYPI2019007226A patent/MY195426A/en unknown
- 2018-06-18 SG SG11201911602RA patent/SG11201911602RA/en unknown
- 2018-06-18 JP JP2019571446A patent/JP6913968B2/ja active Active
- 2018-06-18 ES ES18820848T patent/ES2912392T3/es active Active
- 2018-06-18 DK DK18820848.2T patent/DK3643707T3/da active
- 2018-06-18 AU AU2018288907A patent/AU2018288907B2/en active Active
- 2018-06-18 EP EP18820848.2A patent/EP3643707B1/fr active Active
- 2018-06-18 CA CA3067696A patent/CA3067696C/fr active Active
- 2018-06-18 PT PT188208482T patent/PT3643707T/pt unknown
- 2018-06-18 HR HRP20220557TT patent/HRP20220557T1/hr unknown
- 2018-06-18 LT LTEPPCT/KR2018/006869T patent/LT3643707T/lt unknown
- 2018-06-18 SI SI201830663T patent/SI3643707T1/sl unknown
- 2018-06-18 MX MX2019015616A patent/MX2019015616A/es unknown
- 2018-06-18 PL PL18820848.2T patent/PL3643707T3/pl unknown
- 2018-06-18 US US16/622,518 patent/US10870629B2/en active Active
- 2018-06-18 KR KR1020180069590A patent/KR102015355B1/ko active IP Right Grant
- 2018-06-18 CN CN201880041217.3A patent/CN110770212B/zh active Active
-
2019
- 2019-11-26 PH PH12019502665A patent/PH12019502665A1/en unknown
- 2019-12-18 CL CL2019003727A patent/CL2019003727A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018288907A1 (en) | 2020-01-23 |
| KR20180138169A (ko) | 2018-12-28 |
| PH12019502665A1 (en) | 2020-10-26 |
| US20200207724A1 (en) | 2020-07-02 |
| DK3643707T3 (da) | 2022-05-09 |
| KR102015355B1 (ko) | 2019-10-23 |
| LT3643707T (lt) | 2022-05-25 |
| PT3643707T (pt) | 2022-05-04 |
| JP6913968B2 (ja) | 2021-08-04 |
| JP2020524175A (ja) | 2020-08-13 |
| BR112019027183A2 (pt) | 2020-06-30 |
| CL2019003727A1 (es) | 2020-07-03 |
| MX2019015616A (es) | 2020-02-26 |
| CN110770212B (zh) | 2022-11-22 |
| MY195426A (en) | 2023-01-20 |
| HRP20220557T1 (hr) | 2022-06-10 |
| ES2912392T3 (es) | 2022-05-25 |
| AU2018288907B2 (en) | 2020-05-07 |
| PL3643707T3 (pl) | 2023-06-12 |
| EA037781B1 (ru) | 2021-05-20 |
| EA202090071A1 (ru) | 2020-04-16 |
| CN110770212A (zh) | 2020-02-07 |
| SI3643707T1 (sl) | 2022-06-30 |
| SG11201911602RA (en) | 2020-01-30 |
| US10870629B2 (en) | 2020-12-22 |
| EP3643707B1 (fr) | 2022-02-23 |
| EP3643707A1 (fr) | 2020-04-29 |
| EP3643707A4 (fr) | 2021-06-09 |
| RS63205B1 (sr) | 2022-06-30 |
| CA3067696A1 (fr) | 2018-12-27 |
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