CA3066048A1 - Polytherapie - Google Patents

Polytherapie Download PDF

Info

Publication number
CA3066048A1
CA3066048A1 CA3066048A CA3066048A CA3066048A1 CA 3066048 A1 CA3066048 A1 CA 3066048A1 CA 3066048 A CA3066048 A CA 3066048A CA 3066048 A CA3066048 A CA 3066048A CA 3066048 A1 CA3066048 A1 CA 3066048A1
Authority
CA
Canada
Prior art keywords
antibody
icos
antigen binding
binding portion
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3066048A
Other languages
English (en)
Inventor
Meixia BI
Christopher B. Hopson
Patrick A. MAYES
Sapna YADAVILLI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Intellectual Property Development Ltd
Original Assignee
GlaxoSmithKline Intellectual Property Development Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline Intellectual Property Development Ltd filed Critical GlaxoSmithKline Intellectual Property Development Ltd
Publication of CA3066048A1 publication Critical patent/CA3066048A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne des procédés de traitement du cancer chez un patient en ayant besoin, le procédé comprenant l'administration au patient d'une quantité efficace d'un agent dirigé contre l'ICOS humain et d'une quantité efficace d'un agent dirigé contre PD-1 humain ou PD-Ll humain séquentiellement. L'invention concerne également un anticorps anti-ICOS ou un fragment de liaison à l'antigène de celui-ci et un anticorps anti-PD-1 ou un fragment de liaison à l'antigène de celui-ci pour une utilisation séquentielle dans le traitement du cancer chez un être humain qui en a besoin. L'invention concerne un anticorps anti-ICOS ou un fragment de liaison à l'antigène de celui-ci et un anticorps anti-PD-Ll ou un fragment de liaison à l'antigène de celui-ci pour une utilisation séquentielle dans le traitement du cancer chez un être humain qui en a besoin.
CA3066048A 2017-06-09 2018-06-08 Polytherapie Pending CA3066048A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762517309P 2017-06-09 2017-06-09
US62/517,309 2017-06-09
US201862666278P 2018-05-03 2018-05-03
US62/666,278 2018-05-03
PCT/IB2018/054167 WO2018225033A1 (fr) 2017-06-09 2018-06-08 Polythérapie

Publications (1)

Publication Number Publication Date
CA3066048A1 true CA3066048A1 (fr) 2018-12-13

Family

ID=62873504

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3066048A Pending CA3066048A1 (fr) 2017-06-09 2018-06-08 Polytherapie

Country Status (6)

Country Link
EP (1) EP3634483A1 (fr)
JP (1) JP2020522555A (fr)
CN (1) CN110869049A (fr)
BR (1) BR112019025325A2 (fr)
CA (1) CA3066048A1 (fr)
WO (1) WO2018225033A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116640214A (zh) 2016-08-09 2023-08-25 科马布有限公司 分离抗体及其应用
WO2019122882A1 (fr) 2017-12-19 2019-06-27 Kymab Limited Anticorps bispécifique pour icos et pd-l1
US20230140694A1 (en) * 2020-04-14 2023-05-04 GlaxoSmithKline Intellectual Property Developement Limited Combination treatment for cancer involving anti-icos and anti-pd1 antibodies, optionally further involving anti-tim3 antibodies
US20230149543A1 (en) * 2020-04-14 2023-05-18 Glaxosmithkline Intellectual Property Development Limited Combination treatment for cancer based upon an icos antbody and a pd-l1 antibody tgf-bets-receptor fusion protein

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57106673A (en) 1980-12-24 1982-07-02 Chugai Pharmaceut Co Ltd Dibenzo(b,f)(1,4)oxazepin derivative
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
JP3871503B2 (ja) 1999-08-30 2007-01-24 日本たばこ産業株式会社 免疫性疾患治療剤
JP4210454B2 (ja) 2001-03-27 2009-01-21 日本たばこ産業株式会社 炎症性腸疾患治療剤
JP4212278B2 (ja) 2001-03-01 2009-01-21 日本たばこ産業株式会社 移植片拒絶反応抑制剤
JP4488740B2 (ja) 2001-11-13 2010-06-23 ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド 免疫細胞活性化を調節する作用剤およびその使用方法
AU2003281200A1 (en) 2002-07-03 2004-01-23 Tasuku Honjo Immunopotentiating compositions
AU2003288675B2 (en) 2002-12-23 2010-07-22 Medimmune Limited Antibodies against PD-1 and uses therefor
EP1591527B1 (fr) 2003-01-23 2015-08-26 Ono Pharmaceutical Co., Ltd. Substance specifique a pd-1 humain
CN109485727A (zh) 2005-05-09 2019-03-19 小野药品工业株式会社 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法
MX2007015942A (es) 2005-07-01 2008-03-07 Medarex Inc Anticuerpos monoclonales humanos para ligandos 1 (pd-l1) de muerte programada.
US20080279851A1 (en) 2007-05-07 2008-11-13 Medlmmune, Llc Anti-icos antibodies and their use in treatment of oncology, transplantation and autoimmune disease
DK2170959T3 (da) 2007-06-18 2014-01-13 Merck Sharp & Dohme Antistoffer mod human programmeret dødsreceptor pd-1
US8168757B2 (en) 2008-03-12 2012-05-01 Merck Sharp & Dohme Corp. PD-1 binding proteins
AU2009288289B2 (en) 2008-08-25 2012-11-08 Amplimmune, Inc. PD-1 antagonists and methods of use thereof
JP5794917B2 (ja) 2008-09-12 2015-10-14 アイシス・イノベーション・リミテッドＩｓｉｓ Ｉｎｎｏｖａｔｉｏｎｌｉｍｉｔｅｄ Ｐｄ−１特異抗体およびその使用
AU2009290544B2 (en) 2008-09-12 2015-07-16 Oxford University Innovation Limited PD-1 specific antibodies and uses thereof
CN102264762B (zh) 2008-09-26 2018-03-27 达纳-法伯癌症研究公司 人抗pd‑1、pd‑l1和pd‑l2的抗体及其应用
EP2358392B1 (fr) 2008-11-12 2019-01-09 MedImmune, LLC Formulation d'anticorps
TWI686405B (zh) 2008-12-09 2020-03-01 建南德克公司 抗ｐｄ-ｌ１抗體及其於增進ｔ細胞功能之用途
WO2011041613A2 (fr) * 2009-09-30 2011-04-07 Memorial Sloan-Kettering Cancer Center Immunothérapie combinée pour le traitement du cancer
EP2504028A4 (fr) 2009-11-24 2014-04-09 Amplimmune Inc Inhibition simultanée de pd-l1/pd-l2
RS60033B1 (sr) 2009-11-24 2020-04-30 Medimmune Ltd Ciljano vezujući agensi usmereni na b7-h1
US20110280877A1 (en) 2010-05-11 2011-11-17 Koji Tamada Inhibition of B7-H1/CD80 interaction and uses thereof
CN101898945B (zh) 2010-07-27 2013-05-08 大连理工大学 盐析萃取发酵液中丙酮和丁醇的方法
EP2691419B1 (fr) 2011-03-31 2016-11-09 INSERM - Institut National de la Santé et de la Recherche Médicale Anticorps dirigés contre icos et utilisation de ceux-ci
KR102049817B1 (ko) 2011-08-01 2019-12-02 제넨테크, 인크. Pd-1 축 결합 길항제 및 mek 억제제를 사용하는 암 치료 방법
BR112014012819B1 (pt) 2011-11-28 2022-08-16 Merck Patent Gmbh Anticorpo anti-pd-l1 ou fragmento de ligação ao antígeno do mesmo e composição
US9212224B2 (en) 2012-05-15 2015-12-15 Bristol-Myers Squibb Company Antibodies that bind PD-L1 and uses thereof
KR20150023811A (ko) * 2012-06-21 2015-03-05 컴퓨젠 엘티디. 암의 치료를 위한 lsr 항체 및 그의 용도
WO2014033327A1 (fr) 2012-09-03 2014-03-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Anticorps anti-icos pour le traitement de la réaction greffe contre hôte
CA2886433C (fr) 2012-10-04 2022-01-04 Dana-Farber Cancer Institute, Inc. Anticorps monoclonaux humains anti pd-l1 et procedes d'utilisation
EP3030322A2 (fr) * 2013-08-05 2016-06-15 Cambridge Enterprise Limited Inhibition de la signalisation cxr4 en immunothérapie anticancéreuse
MA41414A (fr) * 2015-01-28 2017-12-05 Centre Nat Rech Scient Protéines de liaison agonistes d' icos
SG11201707769VA (en) 2015-03-23 2017-10-30 Jounce Therapeutics Inc Antibodies to icos
US20180230431A1 (en) * 2015-08-07 2018-08-16 Glaxosmithkline Intellectual Property Development Limited Combination Therapy

Also Published As

Publication number Publication date
CN110869049A (zh) 2020-03-06
EP3634483A1 (fr) 2020-04-15
JP2020522555A (ja) 2020-07-30
BR112019025325A2 (pt) 2020-06-23
WO2018225033A1 (fr) 2018-12-13

Similar Documents

Publication Publication Date Title
JP7325959B2 (ja) 腫瘍特異的細胞の枯渇のための抗ＣＤ２５ ＦＣγ受容体二重特異性抗体
JP2022065073A (ja) Ｂｃｍａ結合分子及びその使用方法
AU2015295946B2 (en) Anti-PD-1 antibody and use thereof
JP2023130380A (ja) Ｇｐｒｃ５ｄキメラ抗原受容体及びそれを発現する細胞
KR20190039421A (ko) 항-tigit 항체, 항-pvrig 항체 및 이들의 조합
CA3124168A1 (fr) Anticorps anti-cd28 x anti-cd22 bispecifiques et leurs utilisations
CA3123420A1 (fr) Anticorps anti-muc16 x anti-cd28 bispecifiques et leurs utilisations
Berezhnoy et al. Development and preliminary clinical activity of PD-1-guided CTLA-4 blocking bispecific DART molecule
CA3066048A1 (fr) Polytherapie
EP3494140A1 (fr) Polythérapie à base d'anticorps anti-icos et anti-pd-1
JP7383620B2 (ja) 養子細胞療法およびチェックポイント阻害剤を使用する併用療法
KR20200140315A (ko) 항-cd27 항체 및 그의 용도
CA3132198A1 (fr) Polytherapies anticancereuses comprenant des agents de blocage de ctla-4 et pd-1
CN115135344A (zh) 在疗法中使用的抗体
KR20220025739A (ko) T-세포 활성화를 위한 항체
WO2023285552A1 (fr) Agents de liaison multispécifiques contre cd40 et cd137 en polythérapie du cancer
US20200181275A1 (en) Combination therapy with icos agonist and ox40 agonist to treat cancer
US20200190194A1 (en) Combination therapy
CN110662764A (zh) 抗程序性死亡配体1(pd-l1)抗体及其治疗用途
US20200190195A1 (en) Combination therapy with icos agonist and ox40 agonist to treat cancer
WO2020086476A1 (fr) Schéma posologique
WO2022268740A1 (fr) Régime posologique combiné d'agents de liaison cd137 et pd-l1
EA040773B1 (ru) Анти-tigit антитела, анти-pvrig антитела и их комбинации