CA3062452C - Compositions, combinaisons et methodes connexes pour le traitement de troubles neurologiques - Google Patents
Compositions, combinaisons et methodes connexes pour le traitement de troubles neurologiques Download PDFInfo
- Publication number
- CA3062452C CA3062452C CA3062452A CA3062452A CA3062452C CA 3062452 C CA3062452 C CA 3062452C CA 3062452 A CA3062452 A CA 3062452A CA 3062452 A CA3062452 A CA 3062452A CA 3062452 C CA3062452 C CA 3062452C
- Authority
- CA
- Canada
- Prior art keywords
- compound
- hydrogen
- phenoxy
- propan
- deramciclane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA3138116A CA3138116A1 (fr) | 2017-05-04 | 2018-05-03 | Nouvelles compositions, combinaisons et methodes connexes |
Applications Claiming Priority (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762501696P | 2017-05-04 | 2017-05-04 | |
US62/501,696 | 2017-05-04 | ||
USPCT/US2017/048748 | 2017-08-25 | ||
PCT/US2017/048748 WO2018039642A1 (fr) | 2016-08-26 | 2017-08-25 | Compositions et procédés associés |
TW106129169 | 2017-08-28 | ||
TW106129169A TW201815387A (zh) | 2016-08-26 | 2017-08-28 | 組成物及其方法 |
US201862634162P | 2018-02-22 | 2018-02-22 | |
US62/634,162 | 2018-02-22 | ||
US201862636099P | 2018-02-27 | 2018-02-27 | |
US201862635554P | 2018-02-27 | 2018-02-27 | |
US62/636,099 | 2018-02-27 | ||
US62/635,554 | 2018-02-27 | ||
US201862636171P | 2018-02-28 | 2018-02-28 | |
US62/636,171 | 2018-02-28 | ||
PCT/US2018/030978 WO2018204713A1 (fr) | 2017-05-04 | 2018-05-03 | Targeted drug rescue avec de nouvelles compositions, associations et procédés correspondants |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3138116A Division CA3138116A1 (fr) | 2017-05-04 | 2018-05-03 | Nouvelles compositions, combinaisons et methodes connexes |
Publications (2)
Publication Number | Publication Date |
---|---|
CA3062452A1 CA3062452A1 (fr) | 2018-11-08 |
CA3062452C true CA3062452C (fr) | 2023-10-24 |
Family
ID=65431106
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3138116A Pending CA3138116A1 (fr) | 2017-05-04 | 2018-05-03 | Nouvelles compositions, combinaisons et methodes connexes |
CA3062452A Active CA3062452C (fr) | 2017-05-04 | 2018-05-03 | Compositions, combinaisons et methodes connexes pour le traitement de troubles neurologiques |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3138116A Pending CA3138116A1 (fr) | 2017-05-04 | 2018-05-03 | Nouvelles compositions, combinaisons et methodes connexes |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP3618819A4 (fr) |
JP (2) | JP7514078B2 (fr) |
KR (2) | KR102444803B1 (fr) |
CN (1) | CN110831584B (fr) |
AU (2) | AU2018261654A1 (fr) |
BR (1) | BR112019022902A2 (fr) |
CA (2) | CA3138116A1 (fr) |
IL (1) | IL270326B2 (fr) |
MA (1) | MA49464A (fr) |
RU (1) | RU2760558C9 (fr) |
TW (1) | TWI787260B (fr) |
WO (1) | WO2018204713A1 (fr) |
ZA (1) | ZA201908006B (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2022526101A (ja) * | 2019-03-18 | 2022-05-23 | アヴェニール ファーマシューティカルズ, インコーポレイテッド | 重水素化デキストロメトルファン及びキニジンを使用して統合失調症の陰性症状を治療する方法 |
WO2020246143A1 (fr) * | 2019-06-06 | 2020-12-10 | Jsr株式会社 | Composition de résine sensible au rayonnement, procédé de formation d'un modèle de réserve, et composé |
EP4153564A4 (fr) | 2020-05-19 | 2024-06-19 | Cybin IRL Limited | Dérivés de tryptamine deutérés et procédés d'utilisation |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4241065A (en) * | 1979-07-02 | 1980-12-23 | E. I. Du Pont De Nemours And Company | Fluoro analogs of hydrocodone and oxycodone useful as analgesics, narcotic antagonists or both |
US4950658A (en) * | 1988-12-06 | 1990-08-21 | Board Of Trustees Of Southern Illinois Univ. | Method of medical treatment of Alzheimer's disease |
US5891885A (en) * | 1996-10-09 | 1999-04-06 | Algos Pharmaceutical Corporation | Method for treating migraine |
US6207674B1 (en) * | 1999-12-22 | 2001-03-27 | Richard A. Smith | Dextromethorphan and oxidase inhibitor for weaning patients from narcotics and anti-depressants |
US6335371B1 (en) * | 2000-11-28 | 2002-01-01 | Orion Corporation | Method for inducing cognition enhancement |
TWI326214B (en) | 2002-07-17 | 2010-06-21 | Avanir Pharmaceuticals Inc | Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders |
US20070099947A1 (en) * | 2005-11-03 | 2007-05-03 | Alkermes, Inc. | Methods and compositions for the treatment of brain reward system disorders by combination therapy |
KR20080097443A (ko) | 2006-02-03 | 2008-11-05 | 아바니르 파마슈티컬스 | 덱스트로메토판 및 퀴니딘을 포함하는, 우울, 불안 및 신경퇴행성 장애 치료용 약제학적 조성물 |
NZ582124A (en) * | 2007-05-21 | 2012-07-27 | Reviva Pharmaceuticals Inc | Compositions, synthesis, and methods of using quinolinone based atypical antipsychotic agents |
US8017623B2 (en) * | 2008-07-03 | 2011-09-13 | Trinity Laboratories, Inc. | Dextromethorphan hydrochloride |
US9737531B2 (en) * | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
CN105491885B (zh) * | 2013-03-07 | 2018-09-25 | 思想实验室有限责任公司 | 疼痛药物组合及其用途 |
WO2014145568A2 (fr) * | 2013-03-15 | 2014-09-18 | Kinemed, Inc. | Biomarqueurs |
CN109890371A (zh) * | 2016-08-26 | 2019-06-14 | 斯瑞尼瓦萨饶·韦帕切杜 | 组合物及其方法 |
-
2018
- 2018-05-03 RU RU2019137004A patent/RU2760558C9/ru active
- 2018-05-03 EP EP18794381.6A patent/EP3618819A4/fr active Pending
- 2018-05-03 WO PCT/US2018/030978 patent/WO2018204713A1/fr active Application Filing
- 2018-05-03 CA CA3138116A patent/CA3138116A1/fr active Pending
- 2018-05-03 KR KR1020217033764A patent/KR102444803B1/ko active IP Right Grant
- 2018-05-03 KR KR1020197035796A patent/KR20200062078A/ko not_active Application Discontinuation
- 2018-05-03 JP JP2019560216A patent/JP7514078B2/ja active Active
- 2018-05-03 AU AU2018261654A patent/AU2018261654A1/en not_active Abandoned
- 2018-05-03 CA CA3062452A patent/CA3062452C/fr active Active
- 2018-05-03 BR BR112019022902A patent/BR112019022902A2/pt active Search and Examination
- 2018-05-03 MA MA049464A patent/MA49464A/fr unknown
- 2018-05-03 CN CN201880037396.3A patent/CN110831584B/zh active Active
- 2018-05-04 TW TW107115320A patent/TWI787260B/zh active
-
2019
- 2019-10-31 IL IL270326A patent/IL270326B2/en unknown
- 2019-12-02 ZA ZA2019/08006A patent/ZA201908006B/en unknown
-
2021
- 2021-08-13 AU AU2021215274A patent/AU2021215274B2/en active Active
-
2023
- 2023-07-21 JP JP2023119151A patent/JP2023143940A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
RU2019137004A3 (fr) | 2021-06-04 |
AU2018261654A1 (en) | 2019-11-14 |
BR112019022902A2 (pt) | 2020-05-19 |
EP3618819A4 (fr) | 2021-01-20 |
RU2760558C9 (ru) | 2022-02-22 |
CA3138116A1 (fr) | 2018-11-08 |
IL270326B2 (en) | 2023-02-01 |
IL270326B (en) | 2022-10-01 |
CA3062452A1 (fr) | 2018-11-08 |
JP7514078B2 (ja) | 2024-07-10 |
IL270326A (fr) | 2018-05-03 |
AU2021215274A1 (en) | 2021-09-02 |
TWI787260B (zh) | 2022-12-21 |
MA49464A (fr) | 2020-04-29 |
CN110831584A (zh) | 2020-02-21 |
RU2019137004A (ru) | 2021-06-04 |
ZA201908006B (en) | 2021-04-28 |
CN110831584B (zh) | 2023-03-10 |
RU2760558C2 (ru) | 2021-11-29 |
KR20210130827A (ko) | 2021-11-01 |
KR20200062078A (ko) | 2020-06-03 |
TW201842902A (zh) | 2018-12-16 |
JP2023143940A (ja) | 2023-10-06 |
AU2021215274B2 (en) | 2022-11-03 |
JP2020518617A (ja) | 2020-06-25 |
KR102444803B1 (ko) | 2022-09-19 |
EP3618819A1 (fr) | 2020-03-11 |
WO2018204713A1 (fr) | 2018-11-08 |
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Legal Events
Date | Code | Title | Description |
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EEER | Examination request |
Effective date: 20191104 |
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EEER | Examination request |
Effective date: 20191104 |
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EEER | Examination request |
Effective date: 20191104 |
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EEER | Examination request |
Effective date: 20191104 |
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EEER | Examination request |
Effective date: 20191104 |
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EEER | Examination request |
Effective date: 20191104 |
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EEER | Examination request |
Effective date: 20191104 |
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EEER | Examination request |
Effective date: 20191104 |
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EEER | Examination request |
Effective date: 20191104 |
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EEER | Examination request |
Effective date: 20191104 |
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EEER | Examination request |
Effective date: 20191104 |
|
EEER | Examination request |
Effective date: 20191104 |
|
EEER | Examination request |
Effective date: 20191104 |